Effect of taurine on wound healing

Abstract

Taurine which has antioxidant effects is also known to have effects on cell proliferation, inflammation and collagenogenesis. The aim of this study was to investigate the effect of taurine on incisional skin wounds.The mice incised on the dorsal area were divided into control and experimental groups. Saline was injected intraperitoneally to half of the animals in the control group and locally applied to the other half. Fifty mM taurine solution was given intraperitoneally to the first half of the experimental animals and locally to the second half of the experimental group.After four days of treatment, malondialdehyde (MDA) and histamine levels as well as the tensile strength of the wound tissue were measured. Structural alterations in epidermis and dermis were histologically evaluated.The locally administreated taurine significantly increased wound tensile strength by decreasing the MDA and histamine levels and prevented the degranulation of the mast cells. These observations suggest that taurine may be useful on wound healing.

Effect of the Topical Use of the Antioxidant Taurine on the Two Basement Membrane Proteins of Regenerating Oral Gingival Epithelium

“…Therefore, the current study was focused on the regeneration of oral gingival epithelium with the use of topical taurine during gingival wound healing. Previous publications assessed the effects of topical taurine use on oral mucosa and skin during the wound healing processes in animal models 4,6,7 . In the present study, we show basal membrane changes in human oral marginal epithelium with taurine.…”

“…In our single‐masked study, the efficacy of 1% (wt/vol) taurine‐hydrated collagen membrane on gingival healing is examined. In previous studies, taurine‐loaded gels or membranes with a concentration between 1.5% and 15% were evaluated in both experimental and clinical models 6‐8,10 . Sofuoglu 9 demonstrated the best releasing rate with 1% to 10% taurine solution from a collagen membrane in his in vitro study.…”

“…Taurine (2‐aminoethanesulfonic acid), an essential amino acid found in most mammals, plays an important physiologic and pathologic role in various organs and tissue components. These include: osmoregulation; membrane stabilization; modulation of calcium levels; and antioxidation, antiapoptotic, anti‐inflammatory, and antilipid activities 4‐6 . The antioxidant effects of taurine affect cell proliferation, inflammation, and collagenosis 7 .…”

“…The antioxidant effects of taurine affect cell proliferation, inflammation, and collagenosis 7 . Taurine's antioxidant and antiapoptosis effects improve wound healing, and it also prevents damage by oxidation on incisional skin wounds 6,8 …”

Penetration Profile of Taurine in the Human Skin and Its Distribution in Skin Layers

“…Taurine has also been used to prevent damage by oxidation in many tissues and on incisional skin wounds (10)(11)(12). Due to its antioxidant property, topical formulation containing taurine has been developed to improve wound healing on the skin after exposure to irradiation (13).…”