Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age

Hove, Maike vom; Prenzel, Freerk; Uhlig, Holm H.; Robel-Tillig, E.

doi:10.1016/j.jpeds.2013.07.045

Cited by 162 publications

(128 citation statements)

References 26 publications

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“…Interestingly, significant impairments of airway function have been reported not only in ''old BPD'' patients, but also in BPD children born in the post-surfactant era [148][149][150][151]. This finding underscores the detrimental effect of lung immaturity on respiratory health over the years, even when surfactants and antenatal steroids were used and ventilatory support was less aggressive.…”

Section: Long-term Consequences Of Prematurity and Bpdmentioning

confidence: 98%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

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Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life. In addition to a genetic predisposition, prenatal and early-life environmental exposures have a persistent impact on respiratory health. Acting during a critical phase of lung development, these factors may change lung structure and metabolism, and may induce maladaptive responses to harmful agents, which will affect the whole lifespan.Some environmental factors, such as exposure to cigarette smoke, type of childbirth and diet, may be modifiable, but it is more difficult to influence other factors, such as preterm birth and early exposure to viruses or allergens.Here, we bring together recent literature to analyse the critical aspects involved in the early stages of lung development, going back to prenatal and perinatal events, and we discuss the mechanisms by which noxious factors encountered early on may have a lifelong impact on respiratory health.We briefly comment on the need for early disease biomarkers and on the possible role of ''-omic'' technologies in identifying risk profiles predictive of chronic respiratory conditions. Such profiles could guide the ideation of effective preventive strategies and/or targeted early lifestyle or therapeutic interventions. @ERSpublications Early-life factors have a role in onset of asthma and COPD; early postnatal interventions may promote lung health http://ow.ly/BvUrx

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Section: Long-term Consequences Of Prematurity and Bpdmentioning

confidence: 98%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

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“…The current definitions of BPD have poor predictive value for longer-term pulmonary outcomes (4), in part because these outcomes are frequent in this population without BPD (27,28). The early CPAP versus immediate intubation and surfactant arm of the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) trial illustrates the problem (7).…”

Section: Original Researchmentioning

confidence: 99%

Comparisons and Limitations of Current Definitions of Bronchopulmonary Dysplasia for the Prematurity and Respiratory Outcomes Program

et al. 2015

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“…Again, variable definitions of BPD were used. The majority of studies (n = 26) used case-control study design (18,19,22,23,25,28,29,32,34,35,37,39,41,42,44,45,54,56,59,62,63,66,67,70,71,75), and the remaining used either retrospective (n = 4) or prospective (n = 4) cohort study designs (20,24,36,43,49,52,57,60).…”

Section: N = 90mentioning

confidence: 99%

Understanding the Short- and Long-Term Respiratory Outcomes of Prematurity and Bronchopulmonary Dysplasia

Islam¹,

Keller

Aschner

et al. 2015

Am J Respir Crit Care Med

275

229

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Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease associated with premature birth that primarily affects infants born at less than 28 weeks' gestational age. BPD is the most common serious complication experienced by premature infants, with more than 8,000 newly diagnosed infants annually in the United States alone. In light of the increasing numbers of preterm survivors with BPD, improving the current state of knowledge of long-term respiratory morbidity for infants with BPD is a priority. We undertook a comprehensive review of the published literature to analyze and consolidate current knowledge of the effects of BPD that are recognized at specific stages of life, including infancy, childhood, and adulthood. In this review, we discuss both the short-term and long-term respiratory outcomes of individuals diagnosed as infants with the disease and highlight the gaps in knowledge needed to improve early and lifelong management of these patients.Keywords: bronchopulmonary dysplasia; respiratory outcomes; preterm birth At a Glance CommentaryScientific Knowledge on the Subject: Currently, there is no comprehensive review of what is known about the short-and long-term respiratory morbidity associated with prematurity and bronchopulmonary dysplasia (BPD). With contemporary improvements in treatment and technology, more infants born prematurely are surviving with poorly understood respiratory sequelae that will present unique challenges to pediatric and ultimately adult pulmonary providers.What This Study Adds to the Field: This review provides both clinicians and researchers with a comprehensive understanding of the range of pulmonary outcomes for survivors of BPD. In reviewing the literature, we have also summarized the research gaps in this field.The significant associations of preterm birth with adult health have become increasingly recognized through epidemiological research and clinical observations (1-3). Complications of preterm birth (,37 completed weeks of gestation) are most often seen in very preterm infants (28-31 wk gestation) and extremely preterm infants (,28 wk gestation) (4), although it is increasingly recognized that even modestly preterm infants are at increased risk of adverse health and developmental outcomes.Preterm birth predisposes individuals to the development of chronic respiratory disease in adulthood, including asthma and chronic obstructive pulmonary disease (COPD) (5). Worldwide, it has been estimated that more than 15 million babies (11% of live births) are born preterm. Health complications associated with preterm birth have recently been implicated as the cause of 36% (1.03 million) of neonatal deaths. Rates of preterm birth are increasing in most countries with reliable

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Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age

Cited by 162 publications

References 26 publications

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Comparisons and Limitations of Current Definitions of Bronchopulmonary Dysplasia for the Prematurity and Respiratory Outcomes Program

Understanding the Short- and Long-Term Respiratory Outcomes of Prematurity and Bronchopulmonary Dysplasia

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