Pulmonary ossific nodule formation in the absence of mitral valve disease

Epstein, Eric J.; Chapman, R W; Coulshed, N; Galloway, R. W.

doi:10.1016/0002-8703(63)90246-1

Cited by 10 publications

(2 citation statements)

References 22 publications

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“…Bone formation with or without marrow components occurring in the interstitial and alveolar compartments is unusual. Pulmonary ossification can be idiopathic or be associated with a variety of underlying pulmonary, cardiac, and systemic disorders (154)(155)(156)(157)(158)(159)(160). As can be seen in Table 2, many of the conditions associated with pulmonary ossification also occur with metastatic or dystrophic calcification; thus, ossification could represent a continuation of either process in the lung (161,162).…”

Section: Pulmonary Ossificationmentioning

confidence: 99%

Calcium Deposition with or without Bone Formation in the Lung

Chan

Morales

Welsh

et al. 2002

Am J Respir Crit Care Med

329

370

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Pulmonary calcification and ossification occurs with a number of systemic and pulmonary conditions. Specific symptoms are often lacking, but calcification may be a marker of disease severity and its chronicity. Pathophysiologic states predisposing to pulmonary calcification and ossification include hypercalcemia, a local alkaline environment, and previous lung injury. Factors such as enhanced alkaline phosphatase activity, active angiogenesis, and mitogenic effects of growth factors may also contribute. The clinical classification of pulmonary calcification includes both metastatic calcification, in which calcium deposits in previously normal lung or dystrophic calcification, which occurs in previously injured lung. Pulmonary ossification can be idiopathic or can result from a variety of underlying pulmonary, cardiac, or extracardiopulmonary disorders. The diagnosis of pulmonary calcification and ossification requires various imaging techniques, including chest radiography, computed tomographic scanning, and bone scintigraphy. Interpretation of the presence of and the specific pattern of calcification or ossification may obviate the need for invasive biopsy. In this review, specific conditions causing pulmonary calcification or ossification that may impact diagnostic and treatment decisions are highlighted. These include metastatic calcification caused by chronic renal failure and orthotopic liver transplantation, dystrophic calcification caused by granulomatous disorders, DNA viruses, parasitic infections, pulmonary amyloidosis, vascular calcification, the idiopathic disorder pulmonary alveolar microlithiasis, and various forms of pulmonary ossification.

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Section: Pulmonary Ossificationmentioning

confidence: 99%

Calcium Deposition with or without Bone Formation in the Lung

Chan

Morales

Welsh

et al. 2002

Am J Respir Crit Care Med

329

370

View full text Add to dashboard Cite

show abstract

“…In the present study, although all the patients had not undergone a preoperative cardiac function test, at least one electrocardiogram was within normal limits, and the clinical signs of mitral stenosis were not confirmed. Epstein et al reported that all cases of diffuse pulmonary ossification without evidence of mitral valve disease have minimal to moderate pulmonary arterial hypertension [28].…”

Section: Discussionmentioning

confidence: 99%