Pulmonary metastasis in patients with gestational trophoblastic disease

Abstract

the treatment of gestational trophoblastic disease (GTD) were reviewed. The diagnosis of metastasis was based on clinical and radiologic evidence (chest X-ray and computed tomography) and on whether the women had elevated levels of serum human chorionic gonadotropin. Particular attention was paid to previous abortions, the interval between previous abortions and the diagnosis of metastasis, the mortality rate, and the need for hysterectomy. Ethics approval was not required for the present study.Of the 82 women, 9 (10.9%) had metastasis: 6 (7.3%) had pulmonary metastasis and 3 (3.6%) had vaginal metastasis. The present study focused on the 6 patients with pulmonary metastasis, 5 of whom were multiparous and had experienced a molar pregnancy within 1 year of the abortion of a preceding pregnancy. The ages of the women ranged from 25 to 51 years (mean, 36 years). A 39-year-old woman had primary GTD with pulmonary metastasis. The diagnosis of pulmonary metastasis was made using chest X-ray and, when the radiologic findings were deemed inconclusive, confirmed using computed tomography.

Treatment of gestational trophoblastic disease: A 10-year experience

“…No less than 85% of metastases are associated with choriocarcinoma [9][10][11][12]. In our sample, all choriocarcinomas metastasized to lungs.…”

“…It has been established that the mortality is higher if pulmonary metastases are developed after term and ectopic pregnancy and mole-unrelated miscarriage [11]. This is associated with the time interval between antecedent pregnancy and metastases development.…”

Treatment and monitoring protocols for gestational trophoblastic disease

“…Izbor lečenja je hemioterapija, na koju većina ovih lezija odgovara brzo i nestaje čak pre nego što titrovi hCG-a padnu na normalne vrednosti. Za neke od plućnih lezija potrebno je da prođe i više od 12 meseci da bi nestale i one su evidentne čak i kada nivoi hCG-a padnu na normalne vrednosti (20). Indikacije za hiruršku intervenciju ograničene su na resekciju plućnih lezija koje su rezistentne na hemioterapiju.…”

Gestational trophoblastic disease: Literature review

“…Za dijagnostiku metastaza GTB koriste se rendgen, kompjuterizovana tomografija i nuklearna magnetna rezonancija [59,60].…”