Treatment of gestational trophoblastic disease: A 10-year experience

Abstract

A retrospective descriptive study about the presence of metastases, epidemiological characteristics and treatment of 104 patients suffering from gestational trophoblastic disease was performed in the period from 1st Jan, 2000 to 31st December, 2010. Of eleven patients who were found to have metastases (10.6%), 72.7% had pulmonary metastases, 27.3 had vaginal, and one patient had both pulmonary and brain metastases. The average age was 33.9. Antecedent molar pregnancy was recorded in 63.6% patients. Invasive mole was more frequent than choriocarcinoma (63.6%). According to the World Health Organization criteria, 7 patients (63.6%) had high risk score (the average World Health Organization score was 8.4). All patients were treated by chemotherapy, the average number of courses being 1.8. Complete remission was achieved in all patients. Treatment of metastatic disease depends on multiple factors. However, combined chemotherapy is the universally accepted treatment. If chemotherapy is individualized and applied on time, the prognosis is good, even in cases with cerebral metastases.

Gestational throphoblastic diseases in North East of Iran: 10 years (2001-2010) prospective epidemiological and clinicopathological study

“…[18] Our results were in accordance to Rolon et al .,[18] as incidence of CCA and HM were 5 (4.2%) and 115 (95.8%), respectively during 10 years from the 120 registered records. Lazović et al .,[19] in a retrospective descriptive study about the presence of metastases, epidemiological characteristics, and 104 patients with GTD found that IM was more frequent than CCA (63.6%).…”

ACR Appropriateness Criteria® Gestational Trophoblastic Disease

“…Radiography Chest. The lungs are the most common site of metastasis in GTN [7,36,60]. Chest radiographs are the primary imaging method recommended by FIGO to detect and count lung metastases for purposes of risk assessment in patients with GTN.…”

“…CT Chest. The lungs are the most common site of metastasis in GTN [7,36,60]. Approximately 30% to 40% of patients assumed to have nonmetastatic disease by radiographs may have CT evidence of micrometastases [20,[38][39][40].…”