Pulmonary metastasis as a primary manifestation of gestational choriocarcinoma in a third trimester pregnancy

Arabi, Ahmad; Ayoola-Adeola, Martins; Nguyen, Huy; Brar, Harpreet K.; Walker, Carol

doi:10.1016/j.gore.2021.100762

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The incidence of malignant neoplasms diagnosed during pregnancy is constantly rising with melanoma, breast and cervical cancer at the forefront [16][17][18] yet other types of malignancies cannot be excluded in pregnancy and have to be considered [19,20]. This includes a choriocarcinoma [21][22][23][24][25], which in our review proved to be the most common neoplastic process resulting in hemoptysis during pregnancy.…”

Section: Introductionmentioning

confidence: 86%

Hemoptysis during pregnancy: a comprehensive review of literature and an unprecedented case report of oropharyngeal carcinoma

et al. 2022

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Objectives: Hemoptysis in pregnancy is a very rare finding causing diagnostic and therapeutic difficulties. The case report of hemoptysis by a 29 years old patient in the 31st week of pregnancy is presented and discussed along with the diagnostic process and treatment provided. Upon pharyngeal cancer occurrence in a pregnant patient a multidisciplinary medical team performed appropriate treatment along with delivery of a healthy newborn at term. Patients and fetal conditions and outcomes were analyzed and compared to available literature in this newly created literature review. Material and methods:After MEDLINE database analysis using formula "hemoptysis" AND "pregnancy" more than 125 results were found published during the period 2002-2022.Almost 30 papers about hemoptysis were found and included for full analysis. Conclusions:The literature review offers a detailed description of previously reported incidents of hemoptysis in pregnancy to gain understanding of the etiology, differential diagnosis, available treatment and predicted future outcomes for both patient and fetus.

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Section: Introductionmentioning

confidence: 86%

Hemoptysis during pregnancy: a comprehensive review of literature and an unprecedented case report of oropharyngeal carcinoma

et al. 2022

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Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions

Dahl

2023

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Case studies reporting intraplacental choriocarcinoma and (IPC) intraplacental “chorangiocarcinoma” have recently increased, with IPC also represented in molecular analyses of gestational trophoblastic neoplasms. Objective.— To provide an overview of 2 intraplacental neoplastic lesions that can have a significant impact on both mother and fetus/infant, focusing on diagnostic characteristics, and ancillary and molecular tools that support diagnosis, determine prognosis, and further elucidate the nature of these lesions. Data Sources.— Data were compiled from a PubMed literature review that included diagnostic and additional keywords within the scope of study for gestational choriocarcinoma in general. Illustrative cases were retrieved from the pathology archives at Michigan Medicine, including the consultation files of the author. Conclusions.— Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called “chorangiocarcinoma” and chorangioma with atypical trophoblast proliferation, is also reviewed. The incidence of these lesions is likely to be underestimated. Heightened suspicion and more liberal placental sampling, particularly when specific clinical features are present, may result in higher detection. Enhanced detection to provide the earliest intervention for both mother and infant may improve prognosis, particularly for asymptomatic disease that may later present with metastasis.

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Pulmonary metastasis as a primary manifestation of gestational choriocarcinoma in a third trimester pregnancy

Cited by 2 publications

References 20 publications

Hemoptysis during pregnancy: a comprehensive review of literature and an unprecedented case report of oropharyngeal carcinoma

Hemoptysis during pregnancy: a comprehensive review of literature and an unprecedented case report of oropharyngeal carcinoma

Intraplacental Gestational Neoplasms: A Review of Clinically Relevant Diagnostically Challenging Lesions

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