Pulmonary metastasectomy in uterine malignancies: outcome and prognostic factors

Anile, Marco; Mantovani, Sara; Pecoraro, Ylenia; Carillo, Carolina; Gherzi, Lorenzo; Pagini, Andreina; Rendina, Erino Angelo; Venuta, Federico; Diso, Daniele

doi:10.21037/jtd.2017.07.46

Cited by 7 publications

(9 citation statements)

References 15 publications

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“…Cervical cancer is highly linked to preventable sexually acquired infection with certain types of HPV (16 and 18) [3]. HPV infection has been shown as the primary agent of cervical cancer and it can be diagnosed through routine screening based on clinical history and/or physical findings and confirmed by cervical punch or cone biopsy [4].…”

Section: Introductionmentioning

confidence: 99%

Correlates of cervical cancer screening uptake among female under graduate students of Aksum University, College of Health Sciences, Tigray, Ethiopia

et al. 2019

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Objectives Cervical cancer is among the leading cancer related causes of morbidity and mortality of women in the world. Ethiopia is among the highest risk countries with age adjusted incidence of cervical cancer 35.9 per 100,000 women or 7619 new cases and 6081 deaths of cervical cancer each year. The aim of this study was to examine correlates of cervical cancer screening uptake among female under graduate students of Aksum University, College of Health Sciences. Data was collected using self-administered structured questionnaire. Variables that were statistically significantly associated with the outcome in bivariate analyses were considered in a logistic multivariate regression analysis. Result Only 17.2% of students were screened for cervical cancer in their lifetime. Both in bivariate and multivariate analysis, sexual experience (AOR = 38.85; 95% CI [8.907, 169.51]), marital status (AOR = 3.481; 95% CI [1.167, 10.380]), Ppace of birth (AOR = 3.359; 95% CI [1.559, 7.235]), and student’s year of study (AOR = 0.005; 95% CI [0.001, 0.031]) were the only correlates of cervical cancer screening uptake among female students. Therefore, the overall cervical cancer screening uptake was low and further study should be done other correlates.

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Section: Introductionmentioning

confidence: 99%

Correlates of cervical cancer screening uptake among female under graduate students of Aksum University, College of Health Sciences, Tigray, Ethiopia

et al. 2019

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“…≥ 3; histology: non-Sq Clavero et al 13 a 2006 1985–2001 70 20 40 7 47 (34–63) (Univariate) DFI < 24 months; primary site: cervix, adjuvant chemotherapy after the initial gynecologic cancer operation Paramanathan and Wright 14 2013 2001–2011 13 0 13 0 66 (NA) NA Adachi et al 15 a 2015 1985–2013 23 4 0 14 82 (NA) (Univariate) DFI < 24 months Paik et al 16 2015 1995–2011 29 21 8 0 48 (NA) (Univariate) symptomatic, tumor no. ≥ 3 Anile et al 17 2017 1997–2010 19 12 4 3 41 (NA) (Multivariate) DFI < 24 months, recurrence after PM Present study 2020 2006–2015 57 25 9 23 69 (54–81) (Univariate) DFI ≤ 24 months Ca carcinoma, CI confidence interval, DFI disease-free interval, NA not available, PM pulmonary metastasectomy, ...…”

Section: Discussionmentioning

confidence: 93%

“…Previous reports on PM for uterine malignancies from 2001 in the English literature are shown in Table 4. [10][11][12][13][14][15][16][17] The numbers of patients ranged from 13 to 133, and the 5-year OS rates ranged from 47 to 82%. In the present study and three previous studies, DFI was shown to have a significant influence on long-term survival.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Outcomes of Pulmonary Metastasectomy for Uterine Malignancies: A Multi-institutional Study in the Current Era

et al. 2020

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Background. Information on pulmonary metastasectomy (PM) for uterine malignancies in the current era is limited. In the present study, we analyzed the clinical course and results of PM for uterine malignancies in the era of modern imaging diagnostics to clarify the role of PM in the current era in a multi-institutional setting. Methods. Fifty-seven patients who underwent PM for uterine malignancies between 2006 and 2015 were retrospectively reviewed. The short-and long-term outcomes, along with factors associated with the prognosis, were analyzed. Details of the clinical course after PM were described. Results. The mean age of patients was 59.4 years. The primary tumor was located in the uterus corpus in 34 cases (60%) and in the uterus cervix in 23 cases (40%). The median disease-free interval (DFI) was 32 months. Forty patients (70%) received fluorine-18-2-fluoro-2-deoxy-Dglucose positron emission tomography/computed tomography before PM, and complete resection was achieved in 52 patients (91%). Postoperative complications occurred in 4 patients (7%). Of the 52 patients who underwent complete resection of pulmonary metastases, 28 experienced recurrence, and among these, 17 (60%) underwent local therapy, including six repeat PMs. Among the 52 patients who underwent complete resection, the 5-year relapse-free survival rate was 40.7% and the 5-year overall survival (OS) rate was 68.8%. The univariate analysis revealed that a DFI of B 24 months was associated with significantly poorer OS. Conclusions. PM for uterine malignancies is safe and provides favorable long-term outcomes in selected patients. Patients with a DFI of[ 24 months have better OS and are good candidates for PM. Uterine malignancies are the fifth most common type of cancer and the eighth leading cause of death in women in Japan. 1 Uterine malignancies consist of uterine corpus malignancies, which include endometrial cancer that originates from the lining of the uterus; uterine sarcoma, which originates from the muscles or support tissue of the uterus; and cervical cancer. It is reported that the rate of lung metastasis is higher in patients with sarcoma than in patients with epithelial gynecologic cancers. 2-4 Because most tumors in patients with epithelial gynecologic malignancies metastasize to the pelvis, vagina, peritoneum,

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“…Our patient had all of these factors and her prognosis was considered good. Surgical resection is a viable option in cases of pulmonary metastasis, including from uterine cancers, and pulmonary metastasectomy using VATS is a safe and feasible procedure in cases with primary uterine malginancies 11 …”

Section: Discussionmentioning

confidence: 99%

Pulmonary metastasis with coexisting pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma 20 years after endometrioid adenocarcinoma surgery: A case report

et al. 2020

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Late pulmonary metastasis from endometrioid adenocarcinoma (EA) is rare, and occurrence after >20 years is extremely rare. Here, we report a case of pulmonary metastasis with coexisting pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma that occurred 20 years after surgery for EA. A 60‐year‐old Japanese woman had previously undergone surgery for primary EA, and 20 years later presented with an abnormality that was detected on chest radiography. Chest computed tomography (CT) revealed two nodules in the right lower lung lobe, which were suspected to be primary lung cancer. Wedge resection was performed, and the intraoperative pathological diagnosis was that of adenocarcinoma with MALT lymphoma; this prompted additional right lower lobectomy. The final pathological diagnosis was pulmonary metastasis from EA with coexisting MALT lymphoma. This is probably the first report on late pulmonary metastasis coexisting with MALT lymphoma 20 years after surgery for EA. Surgeons should be aware of the possibility of late pulmonary recurrence of EA after more than 20 years and should consider aggressive resection. Key points Significant findings of the study Although extremely rare, pulmonary metastasis can occur more than 20 years after surgery for endometrioid adenocarcinoma. Furthermore, pulmonary metastasis from endometrioid adenocarcinoma may coexist with mucosa‐associated lymphoid tissue lymphoma. What this study adds Endometrioid adenocarcinoma requires long‐term postoperative follow‐up to detect recurrence, even in early‐stage cases. Video‐assisted thoracoscopic surgery (VATS) is useful for resecting pulmonary metastasis from endometrioid adenocarcinoma.

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Pulmonary metastasectomy in uterine malignancies: outcome and prognostic factors

Cited by 7 publications

References 15 publications

Correlates of cervical cancer screening uptake among female under graduate students of Aksum University, College of Health Sciences, Tigray, Ethiopia

Correlates of cervical cancer screening uptake among female under graduate students of Aksum University, College of Health Sciences, Tigray, Ethiopia

Long-Term Outcomes of Pulmonary Metastasectomy for Uterine Malignancies: A Multi-institutional Study in the Current Era

Pulmonary metastasis with coexisting pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma 20 years after endometrioid adenocarcinoma surgery: A case report

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