Pulmonary maturity studies in the evaluation of premature labor

Wallace, Roger L.; Herrick, C.Neil

doi:10.1016/0002-9378(81)90225-8

Cited by 14 publications

(18 citation statements)

References 8 publications

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“…Activation of the common pathway of parturition can be the result of multiple pathological processes . Intra‐amniotic inflammation due to microbial invasion of the amniotic cavity (MIAC) is an important cause of spontaneous preterm delivery, and the molecular mechanisms responsible for parturition in this scenario have been extensively studied …”

Section: Introductionmentioning

confidence: 99%

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

Romero

Miranda

Chaiworapongsa

et al. 2014

Am J Reprod Immunol

386

412

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Problem Inflammation and infection play a major role in preterm birth. The purpose of this study was to: 1) determine the prevalence and clinical significance of sterile intra-amniotic inflammation; and 2) examine the relationship between amniotic fluid (AF) concentrations of high mobility group box-1 (HMGB1) and the interval from amniocentesis-to-delivery in patients with sterile intra-amniotic inflammation. Method of Study AF samples obtained from 135 women with preterm labor and intact membranes were analyzed using cultivation techniques as well as broad-range PCR and mass spectrometry (PCR/ESI-MS). Sterile intra-amniotic inflammation was defined when patients with negative AF cultures and without evidence of microbial footprints had intra-amniotic inflammation (AF interleukin-6 ≥ 2.6 ng/mL). Results 1) The frequency of sterile intra-amniotic inflammation was significantly greater than that of microbial-associated intra-amniotic inflammation [26% (35/135) vs. 11% (15/135); (p=0.005)]; 2) patients with sterile intra-amniotic inflammation delivered at comparable gestational ages, had similar rates of acute placental inflammation and adverse neonatal outcomes as patients with microbial-associated intra-amniotic inflammation; and 3) patients with sterile intra-amniotic inflammation and high AF concentrations of HMGB1 (≥ 8.55 ng/mL) delivered earlier than those with low AF concentrations of HMGB1 (p=0.02). Conclusions 1) sterile intra-amniotic inflammation is more frequent than microbial-associated intra-amniotic inflammation; and 2) we propose that danger signals participate in sterile intra-amniotic inflammation in the setting of preterm labor.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

Romero

Miranda

Chaiworapongsa

et al. 2014

Am J Reprod Immunol

386

412

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“…Among the known mechanisms, pathological inflammation is the best‐characterized causal link to preterm labor and birth . To date, the most studied causes of pathological inflammation leading to preterm labor have been (a) intra‐amniotic infection/inflammation resulting from microbial invasion of the amniotic cavity and (b) intra‐amniotic inflammation without detectable microorganisms (ie, sterile intra‐amniotic inflammation) identified by using both molecular and conventional microbiological techniques, proposed to be due to endogenous danger signals, or alarmins . Most research concerning inflammation‐induced preterm labor has therefore focused on the innate limb of immunity .…”

Section: Introductionmentioning

confidence: 99%

Are B cells altered in the decidua of women with preterm or term labor?

Leng

Romero²,

et al. 2019

American J Rep Immunol

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Problem The immunophenotype of B cells at the maternal‐fetal interface (decidua) in labor at term and preterm labor is poorly understood. Method of study Decidual tissues were obtained from women with preterm or term labor and from non‐labor gestational age‐matched controls. Immunophenotyping of decidual B cells was performed using multicolor flow cytometry. Results (a) In the absence of acute or chronic chorioamnionitis, total B cells were more abundant in the decidua parietalis of women who delivered preterm than in those who delivered at term, regardless of the presence of labor; (b) decidual transitional and naïve B cells were the most abundant B‐cell subsets; (c) decidual B1 B cells were increased in women with either labor at term or preterm labor and chronic chorioamnionitis compared to those without this placental lesion; (d) decidual transitional B cells were reduced in women with preterm labor compared to those without labor; (e) naïve, class‐switched, and non–class‐switched B cells in the decidual tissues underwent mild alterations with the process of preterm labor; (f) decidual plasmablasts seemed to increase in women with either labor at term or preterm labor with chronic chorioamnionitis; and (g) decidual B cells expressed high levels of interleukin (IL)‐12, IL‐6, and/or IL‐35. Conclusion Total B cells are not increased with the presence of preterm or term labor; yet, specific subsets (B1 and plasmablasts) undergo alterations in women with chronic chorioamnionitis. Therefore, B cells are solely implicated in the pathological process of preterm labor in a subset of women with chronic inflammation of the placenta. These findings provide insight into the immunology of the maternal‐fetal interface in preterm and term labor.

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“…La plupart des études qui ont montré la présence d'une infection de la cavité amniotique chez les patientes admises pour menace d'accouchement pré-maturé étaient cependant dans l'incapacité d'affirmer que l'infection avait précédé la mise en travail [15][16][17][18][19].…”

Section: La Chronologieunclassified

“…Chez les femmes en menace d'accouchement prématuré, des concentrations élevées d'IL-6 au niveau cervical sont associées à un haut risque d'infection du liquide amniotique (Se66 %, Sp90 %, VPP63,1 %, VPN91,7 %, RR7,7 IC95 [3,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]8]) [102]. De même, chez les femmes asymptomatiques, la concentration d'IL-6 au niveau cervical mesurée à 24 SA est plus élevée chez les femmes qui accoucheront pré-maturément avant 32 SA (IL-6 > 538 pg/mL 95 e percentile, OR = 9,4, IC95 [1,) [96].…”

Section: Interleukine-6 Cervicale (Il-6)unclassified