Pulmonary Manifestations of Kaposi’s Sarcoma

Garay, Stuart M.; M, Belenko; Fazzini, Enrico; Schinella, Roger

doi:10.1378/chest.91.1.39

Cited by 152 publications

(83 citation statements)

References 12 publications

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“…Some clinical studies have shown a higher prevalence in individuals with AIDS who already had the cutaneous form of the disease (over 32%) compared to those without it (3-13%). 3,[9][10][11] In autopsies, however, bronchopulmonary KS was found in 47% of patients with AIDS who had the cutaneous form, which reveals a possible underdiagnosis of pulmonary involvement. 12 Since the variety of opportunistic diseases is great, pulmonary involvement in SK can be difficult to diagnose.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Kaposi’s sarcoma in a female patient: Case report

Petribu¹,

Cisneiros²,

Carvalho³

et al. 2016

Rev. Assoc. Med. Bras.

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SUMMARY Kaposi’s sarcoma (KS) is a multicentric lymphoproliferative malignancy. Most of the time this tumor is confined to the skin and subcutaneous tissue, but it can present with widespread visceral involvement, such as in the lung. Pulmonary KS is the most frequent form in young adult males, in a ratio of 15:1. The disease usually affects individuals with low CD4 lymphocyte counts (<150-200 cells/mm3). We report a case of a female patient aged 35 years, with the presence of skin lesions, self-limiting episodes of diarrhea and weight loss of 15 kg for nearly 9 months, progressing to persistent fever. AIDS was diagnosed and biopsy of the lesions revealed Kaposi’s sarcoma. Computed tomography of the chest showed peribronchovascular thickening, areas of ground glass opacity, condensations with air bronchograms surrounded by ground glass opacity (halo sign) and bilateral pleural effusion. The diagnosis of pulmonary KS is still a challenge, especially due to the occurrence of other opportunistic diseases that may also occur concurrently. Therefore, suspecting this diagnosis based on clinical and laboratory manifestations, and even more with CT findings, is fundamental, especially in patients who already have the cutaneous form of the disease.

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Section: Introductionmentioning

confidence: 99%

Pulmonary Kaposi’s sarcoma in a female patient: Case report

Petribu¹,

Cisneiros²,

Carvalho³

et al. 2016

Rev. Assoc. Med. Bras.

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“…Disseminated Kaposi's sarcoma (KS) is a common problem in patients with the acquired immunodeficiency syndrome. Intrathoracic involvement occurs clinically in as many as a fifth of patients with KS [4,5], and has been reported in 11 of 23 consecutive patients in an autopsy series [6]. Pulmonary KS, usually, follows the appearance of characteristic lesion of the skin [7].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Chylothorax. An Unusual Presentation in the Course of Immune Reconstitution Inflammatory Syndrome, HIV Infection and Kaposi’s Sarcoma: A Case Report

Boultadakis

2014

J Med Cases

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Immune reconstitution inflammatory syndrome (IRIS) is a term used to describe the paradoxical worsening of a pre-existing infection or the presentation of a previously undiagnosed condition in HIV-infected patients soon after commencement of antiretroviral therapy (ART). We report a case of a patient with HIV infection and Kaposi sarcoma, who developed bilateral chylothorax as a manifestation of IRIS, after the initiation of highly active antiretroviral therapy. Bilateral chylothorax is extremely rare and has been associated with significant morbidity and mortality. We present here the successful management with bilateral video-assisted thoracic surgery.

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“…Chest X-ray features of KS have been well described [2][3][4][5][6][7][8]. The most common pattern is bilateral reticulonodular infiltrates, mainly in the lower lobes, associated with pleural effusions.…”

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confidence: 98%

Magnetic resonance imaging findings in pulmonary Kaposi's sarcoma: a series of 10 cases

Khalil¹,

Carette²,

Cadranel³

et al. 1994

Eur Respir J

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Since chest X-ray and CT scan features of Kaposi's sarcoma (KS) are nonspecific, we wanted to test the hypothesis that the histological components of this tumour and/or the associated haemorrhagic component, may result in a characteristic signal pattern on magnetic resonance imaging (MRI). Thoracic MRI was performed in a prospective manner in ten patients with acquired immune deficiency syndrome (AIDS) and pulmonary KS. MRI examinations (1.5 Tesla) included Spin-echo T1 (SE-T1), before and after gadolinium injection, as well as T2-weighted sequences (SE-T2). For each sequence the signal intensity of lesions was measured and compared with each other as well as with the signal intensity of muscle. Results were compared to the hemosiderin content of macrophages in the bronchoalveolar lavage (BAL) in all patients and with histological findings in three. The results were compared to values obtained in a control group of seven patients with pneumocystis carinii pneumonia. SE-T1 showed focally increased signal intensity in the pulmonary parenchyma (n = 5). Signal enhancement in parenchymal lesions (n = 10) and along peribronchovascular trees (n = 5) was observed after gadolinium injection. The second echo of SE-T2 showed a markedly reduced signal intensity in pathologic areas (n = 10). This last finding was not observed in the control group. In conclusion, we have identified a pattern of MRI signal abnormalities suggestive of Kaposi's sarcoma. The MRI signal intensity of KS lesions may be related to the angiomatous and fibrous components of the tumour.(ABSTRACT TRUNCATED AT 250 WORDS)

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Pulmonary Manifestations of Kaposi’s Sarcoma

Cited by 152 publications

References 12 publications

Pulmonary Kaposi’s sarcoma in a female patient: Case report

Pulmonary Kaposi’s sarcoma in a female patient: Case report

Bilateral Chylothorax. An Unusual Presentation in the Course of Immune Reconstitution Inflammatory Syndrome, HIV Infection and Kaposi’s Sarcoma: A Case Report

Magnetic resonance imaging findings in pulmonary Kaposi's sarcoma: a series of 10 cases

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