Pulmonary manifestations of dengue

Marchiori, Edson; Hochhegger, Bruno; Zanetti, Gláucia

doi:10.1590/1806-3713/e20190246

Cited by 21 publications

(25 citation statements)

References 9 publications

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“…In our case the patients had hemoptysis with other accompanying symptoms. In a recent study, hemoptysis was found to be 1.45-2.7 percent in the case of dengue fever, whereas in COVID-19 it was about 13 percent (10,11). COVID-19 characteristics such as spike and nucleocapsid proteins activate the host's immune system, causing the virus to be eliminated.…”

Section: Discussionmentioning

confidence: 91%

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COVID-19 and Dengue infection in Bangladesh: a case of coinfection where hemoptysis as first presentation

Amin

Islam

Khan

et al. 2021

Preprint

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Section: Discussionmentioning

confidence: 91%

“…Dengue fever, hemoptysis, especially diffuse pulmonary infiltration needs to be evaluated in the differential diagnosis. Bilateral regions of ground-glass opacity or consolidation, as well as bilateral pleural effusions, are the most prevalent radiographic findings in dengue that also seen COVID-19 pneumonia (10).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Dengue infection in Bangladesh: a case of coinfection where hemoptysis as first presentation

Amin

Islam

Khan

et al. 2021

Preprint

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“…Fever can be absent in the elderly population or, if present, can occur over 90% of the time [38]. Cough in dengue infection has been reported in 67% of cases, which can be due to pleural effusion observed during plasma leakage in dengue hemorrhagic fever (DHF) [39,40]. Headache in dengue infection has been reported in 89% of cases and more commonly in DHF [41].…”

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 and dengue: two case reports

et al. 2021

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Background The pandemic of this century has overwhelmed the healthcare systems of affected countries, and all resources have been diverted to coronavirus disease 2019. At the onset, coronavirus disease 2019 can present as any other acute febrile undifferentiated illness. In tropical regions, clinicians are increasingly challenged to differentiate these febrile illnesses without the use of diagnostics. With this pandemic, many of these tropical diseases are neglected and go underreported. Dengue is holoendemic in the Maldives, and dengue viruses circulate throughout the year. Reports about coinfections with dengue virus and severe acute respiratory syndrome coronavirus 2 are scarce, and the outcome and the dynamics of the disease may be altered in the presence of coinfection. We have described the clinical manifestation and serial laboratory profile, and highlighted the atypical findings uncommon in dengue infection. Case presentation Case 1 was a 39-year old Asian male, presented on day 6 of dengue infection with warning signs. Reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 that was done as per hospital protocol was found to be positive. Case 2 was a 38-year old Asian male, was admitted on day 5 of illness with symptoms of acute respiratory infection with positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2. Evaluation of progressive leukopenia and thrombocytopenia showed positive dengue serology. Conclusion Clinicians must be conscientious when working on the differential diagnosis of possible tropical diseases in cases of coronavirus disease 2019, specifically, when patients develop hemoconcentration, thrombocytopenia, and transaminitis with elevated expression of aspartate higher than alanine transaminase, which is frequently observed in dengue infection. Caution must be taken during the administration of intravenous fluids when treating patients with coronavirus disease 2019 and dengue coinfection, as coronavirus disease 2019 patients are more prone to develop pulmonary edema. Timely diagnosis and appropriate management are essential to avoid the devastating complications of severe forms of dengue infection. It is important to repeat and reconfirm the dengue serology in coronavirus disease 2019 patients to avoid false positivity. Diligence and care must be taken not to neglect other endemic tropical diseases in the region during the present pandemic.

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“…The non-severe dengue cases are further categorized into those with dengue without warning signs and those with dengue with warning signs. Major warning signs generally reported for dengue are abdominal pain, persistent vomiting, fluid accumulation, mucosal bleeding, lethargy, restlessness, liver enlargement, and an increase in platelet count [ 7 ]. Severe dengue is characterized by the presence of any of these abnormalities, such as severe bleeding, organ impairment, and/or plasma leakage [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication

2021

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Dengue fever is one of the most common viral infections affecting humans. It is an expanding public health problem, particularly in tropical and subtropical regions. No effective vaccine or antiviral therapies against Dengue virus (DENV) infection are available. Therefore, there is a strong need to develop safe and effective therapeutic strategies that can reduce the burden and duration of hospitalizations due to this life-threatening disease. Oligonucleotide-based strategies are considered as an attractive means of inhibiting viral replication since oligonucleotides can be designed to interact with any viral RNA, provided its sequence is known. The resultant targeted destruction of viral RNA interferes with viral replication without inducing any adverse effects on cellular processes. In this review, we elaborate the ribozymes, RNA interference, CRISPR, aptamer and morpholino strategies for the inhibition of DENV replication and discuss the challenges involved in utilizing such approaches.

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Pulmonary manifestations of dengue

Cited by 21 publications

References 9 publications

COVID-19 and Dengue infection in Bangladesh: a case of coinfection where hemoptysis as first presentation

COVID-19 and Dengue infection in Bangladesh: a case of coinfection where hemoptysis as first presentation

Coronavirus disease 2019 and dengue: two case reports

Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication

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