Pulmonary manifestations in inflammatory bowel disease: a prospective study

Desai, Devendra; Patil, Samir; Udwadia, Zarir F; Maheshwari, Shailendra; Abraham, Philip; Joshi, Anand

doi:10.1007/s12664-011-0129-1

Cited by 51 publications

(41 citation statements)

References 15 publications

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“…also found PFT abnormalities, obstructive pattern, abnormal DLCO, and restrictive pattern in 53%, 22.7%, 28.8%, and 1.5%, of patients with UC, respectively. In an Indian study of 27 of 95 (28.5%) patients with inflammatory bowel disease (83 UC and 12 Crohn's disease), small airway obstruction was seen in 18, restrictive defect in 6, and mixed defect in 3 patients 31. Our results are somewhat in accordance with that study 31…”

Section: Discussionsupporting

confidence: 90%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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Background and AimUlcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study.MethodsEighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer.ResultsSubjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control (P < 0.005). Of the 24 patients with abnormal PFT, small airway, restrictive, and obstructive defects were detected in 12 (50%), 11 (45.8%), and 1 (4.2%) patients, respectively. Patients with abnormal PFT more often had active disease (15/24, 62.5% vs 23/63, 36.5%; P = 0.03). No relation of PFT abnormalities was found with age, sex, duration of disease, body mass index, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat UC.ConclusionUC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.

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Section: Discussionsupporting

confidence: 90%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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“…Patients with CD were 1.4-3.0 times more likely to report respiratory symptoms than patients with UC. Other studies showed that respiratory symptoms were reported by 26-48% of IBD patients, which was more frequent than in healthy people [23][24][25][26][27].…”

Section: Epidemiologymentioning

confidence: 91%

“…Up to 58% of these patients had at least one abnormal value in PFT [23][24][25][26][27][28]. Impairment of diffusion lung capacity for carbon monoxide (DLCO) was most commonly found [23][24][25][26][27][28].…”

Section: Epidemiologymentioning

confidence: 99%

“…Most prevalent findings included as follows: peribronchial thickness, bronchiectasis, air trapping, reticular pattern, ground glass opacifications, emphysema, nodular opacifications, mediastinal lymphadenopathy, parenchymal opacifications, and rarely pleural abnormalities [24,26,27,32].…”

Section: Epidemiologymentioning

confidence: 99%

“…However, subclinical involvement detected by HRCT and PFT is believed to be more common [24,27,30,32,50]. Usual symptoms of bronchiolitis included dry or productive cough, progressive breathlessness, wheezes on auscultation.…”

Section: Airways Diseases -Larynx Trachea Bronchi Bronchiolimentioning

confidence: 99%

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