Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

Abstract

Background and AimUlcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study.MethodsEighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer.ResultsSubjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control (P < 0.005). Of the 24 patients with abnormal PFT, small airway, restrictive, and obstructive defects were detected in 12 (50%), 11 (45.8%), and 1 (4.2%) patients, respectively. Patients with abnormal PFT more often had active disease (15/24, 62.5% vs 23/63, 36.5%; P = 0.03). No relation of PFT abnormalities was found with age, sex, duration of disease, body mass index, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat UC.ConclusionUC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.

Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

“…We identified 458 studies from different databases and society meetings; 9 of them were selected after screening. Five studies were excluded with reason [26–30] and four were included for the qualitative and quantitative analysis; three were published papers [18, 31, 32] and one was a meeting abstract [33]. Figure 1 describes the summary of the literature search according to PRISMA standards.…”

Pulmonary Function Tests in children suffering from Inflammatory Bowel Diseases in Zagazig University Hospital

“…Patients with abnormal pulmonary functions had statistically significantly lower body mass index than patients with normal pulmonary functions (P=.020).Also, there was a statistically significant association between pulmonary function and colonoscopy biopsy findings (P=.028). However, no statistically significant differences between other relevant study parameters and pulmonary function of the studied (IBD) patients (P>.05), was shown in table (5). A scatter plot with a regression line of FEV1% against body mass index of the studied (IBD) patients was shown in figure (1).…”

“…16 LF 8.5) to measure the predicted forced vital capacity (FVC), the predicted forced expiratory volume in1 s (FEV1), and their ratio (FEV1/FVC) Normal physiology was defined by all measurements being >80% predicted, a restrictive defect as a reduced (<80% predicted) FVC with an FEV1/FVC ratio of >70% predicted or reduced DLCO (<80% predicted), and an obstructive defect as a reduced FEV1 with a normal FVC and a low FEV1/FVC ratio (<70% predicted). Small airway disease was defined as reduced FEV1 (<70% predicted), low FEV1/ FVC (<70% predicted) ratio, and reduced MEF25-75 (<60 predicted) [5] . Disease activity: Patients with active disease were classified as mild, moderate, or severe as per Truelove score.…”

“…Patients were considered in clinical remission if they had one or two stools a day without blood, no fever, or tachycardia, along with normal Hb determinations and ESR. [5] Extent of disease: Extent of the disease was assessed on colonoscopy as proctitis, leftsided colitis, or pan colitis. Proctitis was defined as involvement of the rectum only, left-sided colitis as left colon up to splenic flexure and pancolitis as extensive disease beyond splenic flexure.…”

“…Proctitis was defined as involvement of the rectum only, left-sided colitis as left colon up to splenic flexure and pancolitis as extensive disease beyond splenic flexure. [5] Ethical Clearance: Written Informed consent was taken from the patient parents to participate in the study. Approval for performing the study was obtained from Pediatrics Departments, Zagazig University Hospitals after taking Institutional Review Board (IRB) approval.…”