Pulmonary MALT Lymphoma with Amyloid Production in a Patient with Primary Sioegren's Syndrome.

Abstract

A 53-year-old womanwasadmitted to our hospital complaining of cough, low grade fever, chest pain and sicca symptoms. A chest radiograph showed an abnormal shadow and chest computed tomography revealed a tumor in left S6. She was diagnosed as Sjogren's syndrome by sialography and histological findings of labial biopsy. The surgically resected tumor specimen showed proliferation of lymphoid cells with lymphoepithelial lesions, which were positive for CD20 and kappa light chain. Kappa light chainpositive amyloid was found within the tumor. The tumor showed rearranged kappa light chain genes. The diagnosis was pulmonary mucosa associated lymphoid tissue lymphoma with amyloid production. (Internal Medicine 41 : 309-311, 2002)

Pulmonary Manifestations of Sjögren’s Syndrome

“…It is therefore very important to evaluate the histological classification of the lung in PSS [15,16,17]. However, the histopathologic pulmonary manifestations of PSS are not well defined in the literature [5,18,19,20,21,22].…”

A large-sized bubbling appearance of the glomerular basement membrane in a patient with pulmonary limited AL amyloidosis and a past history of lupus nephritis

“…Although nodular lesions are very uncommon in pulmonary AL amyloidosis, Rajagopala et al [10] pointed out the relationship between pulmonary AL amyloidosis and Sjögren's syndrome. Nakamura et al [11] and Satani et al [12] also reported on the combination of Sjögren's syndrome and pulmonary mucosaassociated lymphoid tissue (MALT) lymphoma. We cannot determine the precise relationship between the unique pathological features found on renal biopsy and pulmonary limited AL amyloidosis in the present case, which showed no evidence of Sjögren's syndrome or MALT lymphoma.…”

Pulmonary Localized AA Type Amyloidosis with Cyst-like Structures and Marginal Zone B-cell Lymphoma of the MALT Type Coexisting Independently in the Left upper Lung

“…Amyloidosis is also associated with systemic lymphoproliferative disorders and plasma cell dyscrasias (2,5,6 (8). MALT lymphoma sometimes may contain amyloid deposits, but this finding is extremely rare; it has been reported in only 18 cases (3,6,(8)(9)(10)(11)(12)(13)(14). This report presents a case of pulmonary AA (amyloid-associated) type amyloidosis with cyst-like structures and MALT lymphoma coexisting independently in the left upper lobe.…”

“…Cyst-like lesions corresponded to dilated bronchioles infiltrated by amyloidosis (Fig. 2f) (3,6,(8)(9)(10)(11)(12)(13)(14), (4,12,13). MALT of the stomach is considered to be associated with a continuous infection of Helicobactor pylori.…”