Pulmonary Localized AA Type Amyloidosis with Cyst-like Structures and Marginal Zone B-cell Lymphoma of the MALT Type Coexisting Independently in the Left upper Lung

Yanagawa, Naoki; Ogata, Shinya; Motoyama, Teiichi

doi:10.2169/internalmedicine.47.1231

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…AA fibrils are derived from cleavage fragments of the circulating acute phase reactant, SAA. SAA is an apolipoprotein of highdensity lipoprotein (HDL), which like CRP is synthesized in the liver under the transcriptional regulation of cytokines including IL-1, IL-6, and TNF-1α (19)(20)(21). The circulating concentration of SAA tends to parallel that of the much more frequently measured CRP.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Resolution of Multiple Nodular Pulmonary AA Amyloidosis

2010

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A 62-year-old man presented with a two-week history of dry cough. A chest computed tomography (CT) showed three nodular masses of soft tissue density without calcification or cavitary formation in the right lung. F-18 fluorodeoxyglucose PET/CT scan revealed high FDG uptake in two out of three pulmonary nodules. Transbronchial lung biopsy specimens consisted of amorphous eosinophilic deposits that were demonstrated to be amyloid because they were positive for Congo Red staining. After oxidation with permanganate solution, the Congo Red staining disappeared, indicating that this amyloid was amyloid A protein-derived type. There was no evidence of any systemic diseases. We diagnosed the patient as having multiple nodular pulmonary AA amyloidosis. The patient was conservatively managed without treatment, and the pulmonary nodules disappeared spontaneously three months later.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Resolution of Multiple Nodular Pulmonary AA Amyloidosis

2010

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“…Cysts in pulmonary amyloidosis occur less commonly than nodules and interstitial infiltrates. Most cysts when present are associated with nodules 21 and usually involve the AL subtype though cases of AA 31 and transthyretin amyloidosis 21 presenting with cysts have been described. Cystic amyloidosis is also commonly associated with underlying connective-tissue disorders, particularly Sjögren syndrome, where MALT lymphoma may be seen in approximately 30% of the cases.…”

Section: Cystsmentioning

confidence: 99%

“…61 There is one rare description of AA amyloid with concomitant MALT lymphoma presenting as cysts and nodules in the lungs. 31 AA amyloidosis associated with Familial Mediterranean Fever may present as interstitial infiltrates in the lungs. 17,62 Planes et al described a case of biopsy-proven AA amyloid presenting as interstitial infiltrates along with AA amyloid in the kidneys.…”

Section: Aa Amyloidosismentioning

confidence: 99%

Amyloid in the Lung

Baqir

Roden

Moua

2020

Semin Respir Crit Care Med

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Amyloidosis is the term given to abnormal deposition of misfolded precursor proteins at single or multiple sites, leading to organ dysfunction or clinical signs and symptoms. Pulmonary manifestations are nonspecific and may be associated with several amyloid protein subtypes, commonly AL (light chain) and AA (autoimmune) amyloids. Signs or symptoms of amyloid disease may often involve more of the clinical abnormalities of other affected organs than the lungs themselves. Radiologic pulmonary findings include septal and parenchymal ground glass or nodular infiltrates, multiple nodules, cysts, and focal tracheobronchial abnormalities. Lymphadenopathy with or without calcification and pleural effusions has also been reported. Directed therapy is initiated in response to clinical signs or symptoms often as a result of systemic or secondary diseases or conditions. Long-term prognosis is more dependent on the extent of organ involvement where morbidity is often the highest in those with multisystemic disease.

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