Pulmonary intestinal-type adenocarcinoma

Maeda, Ryo; Isowa, Noritaka; Onuma, Hideyuki; Miura, Hiroshi

doi:10.1510/icvts.2007.168716

Cited by 19 publications

(20 citation statements)

References 10 publications

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“…Its diagnosis requires the exclusion of a primary enteric tumor, which, in turn, requires gastroscopy and enteroscopy. Details of the present and 30 previously reported cases of primary lung intestinal adenocarcinoma (11)(12)(13)(14)(15)(16)(17)(18)(19) are shown in Table II. All 31 cases expressed CK7, CK20 or TTF-1; 26 (84%), 13 (42%) and 14 (45%) cases, respectively, were positive for each marker.…”

Section: Discussionmentioning

confidence: 94%

Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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Primary lung enteric adenocarcinoma is a rare type of invasive lung carcinoma. Its morphology and immunohistochemistry are those of colorectal carcinoma, but there is no associated primary colorectal carcinoma. The present study describes the case of a 53-year-old female who presented with an irritating cough and a mass around the right sternoclavicular joint. Comprehensive evaluation revealed involvement of the mediastinum, lungs, right sternoclavicular joint and right kidney. Biopsies from the mediastinal and right sternoclavicular joint tumors showed features of adenocarcinoma. Immunohistochemistry was positive for cytokeratin (CK)20 and caudal type homeobox transcription factor 2, and negative for CK7, thyroid transcription factor-1 and napsin A. Genotypic analysis identified the expression of wild-type epidermal growth factor receptor, Kirsten rat sarcoma viral oncogene homolog, serine/threonine-protein kinase B-Raf and UDP-glucuronosyltransferase 1-1. There was no expression of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase and a moderate expression of excision repair cross-complementation group 1, ribonucleoside-diphosphate reductase large subunit and tubulin β-3 chain. A strong expression of thymidylate synthase and 677TC genotype expression of methylenetetrahydrofolate reductase was observed. Gastroscopy, enteroscopy, colorectal colonoscopy and positron emission tomography-computed tomography failed to find evidence of a gastrointestinal malignancy and primary lung enteric adenocarcinoma was diagnosed. The presence of multiple metastases did not permit curative surgery. The patient was treated with 3 monthly cycles of the XELOX chemotherapy regimen; the response was poor with progression of supraclavicular lesions. Treatment was switched to the TP regimen for 4 monthly cycles, which resulted in a significant reduction in the size of the lung lesions; however, the supraclavicular lesion responded poorly to the treatment. The patient then received 2 cycles of the FOLFIRI regimen; however, the lung and right supraclavicular lesions progressed, causing increased right upper limb pain. The pain was alleviated by palliative surgery. Following surgery, the DP regimen was employed. Follow-up of the patient remains ongoing. The present findings suggest that the early diagnosis and treatment of primary lung enteric adenocarcinoma is likely to improve patient outcome.

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Section: Discussionmentioning

confidence: 94%

Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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“…Central geographical or dotted necrosis, occasional central scarring, and pleural indentation may be present [1]. Tsao et al initially described this tumor in 1991, and about 30 cases have since been described in the English literature [2,3]. In recent years, the concept of PEAC has been proposed by international core panels of experts [4], and it was classified for the first time as a variant of adenocarcinoma in the WHO classification of the lung published this year [1].…”

Section: Discussionmentioning

confidence: 99%

“…The concept and etiology are not clear, but its histological morphology is similar to that of metastatic colorectal carcinoma (MCC) [2].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary enteric adenocarcinoma

Handa

Kai

Ikeda

et al. 2015

Gen Thorac Cardiovasc Surg

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A 70-year-old man was referred to our department due to abnormal shadows on a chest radiograph. Computed tomography of the chest revealed a 3-cm nodule in the right middle lung lobe, and bronchoscopy revealed adenocarcinoma cells with EGFR mutations. A lung resection was performed. Histological analysis revealed tumors comprising tall columnar cells that were similar to an adenocarcinoma of the sigmoid colon that had been resected 13 years previously. Metastatic colorectal carcinoma was initially considered, but immunohistochemical staining indicated pulmonary enteric adenocarcinoma. Pulmonary enteric adenocarcinoma was first described in 1991, and about 30 cases have since been described in the English literature. However, its concept and etiology are not clear. It is important to distinguish pulmonary enteric adenocarcinoma from metastatic colorectal carcinoma because of obvious differences in therapeutic strategies and prognosis, especially with a past history of colorectal carcinoma. Immunohistochemical and gene mutation analyses seemed to be helpful.

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“…PEAC is a rare pathological type. Between 1 May 2005 and 8 October 2015, <20 PEAC-related references have been recorded by PubMed (www.ncbi.nlm.nih.gov/pubmed) and Wanfang (http://g.wanfangdata.com.cn/) (2,3,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary enteric adenocarcinoma with pancreatic metastasis: A case report

Sun

Wang

et al. 2017

Oncology Letters

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Abstract. Pulmonary enteric adenocarcinoma is a markedly rare pathological type of lung adenocarcinoma. As the pancreas is a relatively uncommon site for metastasis, the present case is even more unusual. A 62-year-old male was admitted to hospital following the identification of masses in the left chest wall, right abdominal wall and right upper limb, but with no respiratory symptoms. Computed tomography (CT) of the chest revealed a lump in the lung and a mass in the left chest wall, and 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake by the lumps was increased. An enhanced abdominal CT revealed a hypodense and homogeneous mass on the head of the pancreas, which was slightly enhanced compared with normal pancreatic tissue. In addition, the 18 F-FDG uptake of the lesion was increased and the standardized uptake value (SUV) delayed was not evidently decreased compared with SUVearly. A number of other abnormal metabolic lesions were also identified using positron emission tomography/CT, whereas no abnormal 18 F-FDG uptake was identified in the gastrointestinal organ. Furthermore, rectocolonoscopy was performed to exclude diagnosis of metastatic colorectal adenocarcinoma. The hematoxylin-and eosin-stained smears of the masses in the right lung and left chest demonstrated an enteric pattern, which shared morphological and immunohistochemical (IHC) features with those of colorectal adenocarcinoma. The IHC detection revealed that the lesions in the right lung were positive for cytokeratin 7 (CK7), and negative for CK20 and thyroid transcription factor 1 (TTF-1), and the expression of caudal type homeobox 2 (CDX2) was weakly positive; the masses in the left chest wall were positive for CK7, negative for TTF-1, and CK20 and CDX2 were weakly expressed.

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Pulmonary intestinal-type adenocarcinoma

Cited by 19 publications

References 10 publications

Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature

Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature

Pulmonary enteric adenocarcinoma

Pulmonary enteric adenocarcinoma with pancreatic metastasis: A case report

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