Pulmonary infection by Mycobacterium gordonae in an immunocompromised patient

Aguado, J. M.; Gómez-Garcés, José Luís; Manrique, Amapola; F, Soriano

doi:10.1016/0732-8893(87)90141-6

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…M. mucogenium was found in 2.7% of NTM isolates, representing 5.0% of cases of NTM lung disease in this study. M. gordonae is frequently encountered in clinical laboratories but is almost always considered nonpathogenic [16]. In the present study, M. gordonae was found in 3.9% of NTM isolates, with 1 case being clinically significant.…”

supporting

confidence: 48%

Recent Trends in Clinically Significant Nontuberculous Mycobacteria Isolates at a Korean General Hospital

Kim

Lee

et al. 2014

Ann Lab Med

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Lung disease caused by nontuberculous mycobacteria (NTM) represents an increasing proportion of all mycobacterial diseases. We investigated recent occurrences of NTM and evaluated the clinical significance of NTM isolates from 752 respiratory specimens collected from patients at National Health Insurance Service Ilsan Hospital between January 2007 and May 2011. Specimens were incubated on solid and liquid media (BACTEC MGIT 960, BD, USA) for 6-8 weeks, and PCR and reverse blot hybridization were performed (REBA Myco-ID, Molecules & Diagnostics, Korea). Clinical features of the patients were reviewed through medical records. The most frequently isolated organism was Mycobacterium avium (46.7%), followed by M. intracellulare (14.8%), M. fortuitum (7.2%), and M. abscessus (6.6%). The most common mycobacteria among definitive cases of NTM lung disease were M. avium (42/351, 12.0%), M. intracellulare (19/111, 17.1%), M. abscessus (11/50, 22.0%), M. massiliense (4/13, 30.8%), and M. fortuitum (4/54, 7.4%). Clinically significant cases of NTM lung disease increased from 4 patients in 2007 to 32 in 2011. The mean patient age was 64 yr (range: 35-88 yr), and 58 (64%) patients were women. Patients suffered from cough, productive sputum, and hemoptysis. In summary, the most common mycobacteria causing NTM lung disease were M. avium and M. intracellulare; however, cases of M. massiliense and M. abscessus infection are on the rise in Korea.

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confidence: 48%

Recent Trends in Clinically Significant Nontuberculous Mycobacteria Isolates at a Korean General Hospital

Kim

Lee

et al. 2014

Ann Lab Med

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“…After 2 weeks, sarcoid-like granulomas had formed from epitheloid and giant cells without casefying necroses. These findings are comparable to the histology of those cases with documented lung biopsy [11,16,20,24], Further more, such lesions are in agreement with nodules shown by UF-CT in the present case.…”

Section: Discussionsupporting

confidence: 80%

“…Contreras et al [25] found 82% of all patients with pulmonary infec tion due to NTM (none of them due to M. gordonae) pre senting with underlying lung disease; in addition, 46% presented with a history of tobacco smoking, 40% with alcohol abuse and 36% with cardiovascular disease. In other reports pulmonary infection due to M. gordonae was also associated with underlying lung disease in a majority of cases [10][11][12][13][14][15][16][17]24], In contrast to these find ings, our patient presented with congenital cardiovascular disease and only a short history of tobacco smoking.…”

Section: Discussioncontrasting

confidence: 48%

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Pulmonary Infection due to <i>Mycobacterium gordonae</i> in an Adolescent Immunocompetent Patient

Resch

Eber²,

Beitzke³

et al. 1997

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We report the case of 17-year-old male adolescent immunocompetent patient with an operated transposition of the great arteries after the Mustard technique admitted to our hospital because of a cough and hemoptysis. Two nodules and an area of ground glass appearance located in the lower lobe of the left lung were diagnosed by ultrafast computed tomography (UF-CT) after ruling out cardiovascular complications. The gastric aspirate revealed acid-fast bacilli despite a repeatedly negative tuberculin skin test identified as Mycobacterium gordonae by the Gen-Probe Rapid Diagnostic Test. After an initial standard antimycobacterial therapy with isoniazid, rifampin and pyrazinamide the therapy was changed to clarithromycin and after a treatment course of 14 days, the UF-CT revealed a normal scan of both lungs. The case described suggests that one has to consider M. gordonae as a rare cause of infection even in immunocompetent patients.

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“…Slowly growing nontuberculous mycobacteria, including Mycobacterium kansasii, M. mannum, M. simiae, M. scrofulaceum, M. szulgai, M. gordonae, M. nonchromogenicum, and M. avium-M. intracellulare complex, have been incriminated in various types of human diseases, including skin and soft-tissue infections (20,22,26,(28)(29)(30)(31), pulmonary disease (1,18,20,28,29,31,32), and disseminated disease in nonimmunocompromised patients and in immunocompromised patients, including those with AIDS (8,9,17,18). Susceptibility patterns of the slowly growing nontuberculous mycobacteria can be divided into two groups.…”

mentioning

confidence: 99%

Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system

Brown

Wallace

Onyi

1992

Antimicrob Agents Chemother

122

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MICs of clarithromycin against 324 clinical isolates belonging to eight species of slowly growing nontuberculous mycobacteria were determined by using a broth microdilution system. Isolates were inoculated into twofold drug dilutions in Middlebrook 7H9 broth (pH corrected to 7.4) and then incubated at 30°C for 7 days for Mycobacterium marinum and for 14 days for all other species. The MIC for 90%o of the strains (MIC90) was c0.5 ,ug/ml for isolates of Mycobacterium gordonae (6 strains), Mycobacterium scrofulaceum (5 strains), Mycobacterium szulgai (6 strains), and Mycobacterium kansasii (35 strains). MICs for M. marinum (25 strains) and Mycobacterium avium complex (237 strains) were higher, but 100% and 89%o of the strains, respectively, were susceptible to <4 ,ug/ml. In contrast, MICs for five of six M. simiae strains were >8 ,ug/ml, and the range of MICs for Mycobacterium nonchromogenicum varied from .0.125 to 8 ,ug/ml. For the 237 isolates of M. avium complex, the MIC50 was 2 ,ug/ml and the MIC90 was 8 ,ug/ml. MICs for most isolates (77%) were in the 1-to 4-,ug/ml range. For the 80 isolates in this group known to be from AIDS patients, the MIC50 was 4 ,ug/ml and the MIC90 was 8 ,ug/ml. These MIC studies combined with preliminary clinical trials suggest that clarithromycin may be useful for drug therapy of most species of the slowly growing nontuberculous mycobacteria except M. simiae.Slowly growing nontuberculous mycobacteria, including Mycobacterium kansasii, M. mannum, M. simiae, M. scrofulaceum, M. szulgai, M. gordonae, M. nonchromogenicum, and M. avium-M. intracellulare complex, have been incriminated in various types of human diseases, including skin and soft-tissue infections (20,22,26,(28)(29)(30)(31), pulmonary disease (1,18,20,28,29,31,32), and disseminated disease in nonimmunocompromised patients and in immunocompromised patients, including those with AIDS (8,9,17,18

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Pulmonary infection by Mycobacterium gordonae in an immunocompromised patient

Cited by 15 publications

References 4 publications

Recent Trends in Clinically Significant Nontuberculous Mycobacteria Isolates at a Korean General Hospital

Recent Trends in Clinically Significant Nontuberculous Mycobacteria Isolates at a Korean General Hospital

Pulmonary Infection due to <i>Mycobacterium gordonae</i> in an Adolescent Immunocompetent Patient

Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system

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