Pulmonary<i>Mycobacterium bovis</i>infection in a dog

Burbidge, H. M.; Bennett, PM; Fenwick, Stan; Dupont, Chris L.; Murray, Allan G.; Alley, M.R.

doi:10.1080/00480169.2000.36164

Cited by 15 publications

(12 citation statements)

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“…Some of these clinical signs include non-productive coughing, weight loss, pyrexia, dyspnoea, diarrhoea, vomiting, and anorexia. Further, infected dogs can remain subclinical for long periods of time (Gay et al 2000;Hackendahl et al 2004;Turinelli et al 2004;Parsons et al 2008). As is characteristic of TB, it was difficult to determine the approximate time of exposure or onset of infection in this dog.…”

Section: Discussionmentioning

confidence: 99%

“…Cytological and histopathological examinations are useful for detecting rod-shaped, negative-staining bacilli on routine stains or acid-fast bacilli on Ziehl-Neelsen staining (Gay et al 2000;Hackendahl et al 2004;Parsons et al 2008;Martinho et al 2013). Definitive diagnosis of mycobacterial organisms and species can be made using bacterial culture, and molecular genetic techniques such as PCR or restriction fragment length polymorphism analysis (Hackendahl et al 2004;Parsons et al 2008;Martinho et al 2013;Engelmann et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Three general clinical disease forms are described in the literature (Foster et al 1986;Hackendahl et al 2004;Sykes et al 2007): internal tubercular granuloma formations (tuberculosis type), localised cutaneous nodule formations (leprosy type), and the subcutaneous inflammation type (M. avium complex). Among them, thoracic involvement with tubercle formation is the type most frequently observed with TB infections in dogs because M. tuberculosis requires a high oxygen concentration for replication and survival (Gay et al 2000;Engelmann et al doi: 10.17221/8724-VETMED 2014). Pleurisy and pleural effusion may also develop concurrently and in association with pulmonary TB infection (Gay et al 2000;Turinelli et al 2004;Sykes et al 2007;Parsons et al 2008).…”

mentioning

confidence: 99%

“…Among them, thoracic involvement with tubercle formation is the type most frequently observed with TB infections in dogs because M. tuberculosis requires a high oxygen concentration for replication and survival (Gay et al 2000;Engelmann et al doi: 10.17221/8724-VETMED 2014). Pleurisy and pleural effusion may also develop concurrently and in association with pulmonary TB infection (Gay et al 2000;Turinelli et al 2004;Sykes et al 2007;Parsons et al 2008). However, the formation of giant tubercles in the thoracic cavity, and a comparison of different types of pleural effusion with pulmonary TB have not been described yet in veterinary medicine.…”

mentioning

confidence: 99%

“…Tuberculosis (TB) is a contagious disease in humans and animals and has a wide range of hosts (Gay et al 2000;Hackendahl et al 2004;Turinelli et al 2004;Sykes et al 2007;Parsons et al 2008;Posthaus et al 2011;Martinho et al 2013;Engelmann et al 2014). TB is caused by members of the mycobacterium TB complex that includes M. tuberculosis, M. bovis, M. microti, M. canettii, M. africanum, and M. pinnipedii, all of which form tubercles.…”

mentioning

confidence: 99%

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Pulmonary Mycobacterium tuberculosis infection with giant tubercle formation in a dog: a case report

Park¹,

Lim²,

Kwon³

et al. 2016

Vet. Med. - Czech

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ABSTRACT:An eight-year-old, 4.9 kg, intact male mongrel dog presented with progressive weight loss, anorexia, vomiting, diarrhoea, and open-mouth breathing. A thoracic radiograph showed significant pleural effusion. Upon removal of the pleural effusion, an oval-shaped soft-tissue density mass was identified above the heart base. Two months later, the dog's condition worsened severely, and he was euthanised. A complete necropsy showed all intrathoracic structures were encapsulated by a fibrinous material. A large granuloma was attached between the right cranial lung lobe and the trachea. The cytological evaluation of the pleural effusion showed numerous negative-staining rod structures. Ziehl-Neelsen staining confirmed the presence of acid-fast bacilli. A polymerase chain reaction test confirmed Mycobacterium tuberculosis infection. This work is the first case report of canine pulmonary M. tuberculosis infection in South Korea. To the best of our knowledge, the formation of giant tubercles in canine pulmonary tuberculosis has not been reported recently.Keywords: dog; M. Tuberculosis; pleural effusion; tubercles; tuberculosis List of abbreviations ALP = alkaline phosphatise, ALT = alanine aminotransferase, AST = aspartate transaminase, IL-6 = interleukin-6, PCR = polymerase chain reaction, TB = tuberculosis, TNCC = total nucleated cell count

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Pulmonary Mycobacterium tuberculosis infection with giant tubercle formation in a dog: a case report

Park¹,

Lim²,

Kwon³

et al. 2016

Vet. Med. - Czech

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Epidemiology ofMycobacterium Bovis

Drewe

Pfeiffer

Kaneene

2006

Mycobacterium Bovis Infection in Animals and Humans

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Objective: To describe the clinical characteristics and outcomes in a population of dogs with negative-pressure pulmonary edema (NPPE) and to identify the main causes of the disease. To evaluate any associations with morbidity and mortality.Design: Retrospective study.Setting: Three university teaching hospitals and two private referral centers.Animals: Thirty-five client-owned dogs presented with NPPE. Interventions: NoneMeasurements and Main Results: Data collected included patient characteristics, clinical history, clinicopathological abnormalities, radiographic features, treatments and outcome. Median age was 4 months (range 2-90) and median weight was 7.1 kg (range 1.7-37.2). There were many causes of NPPE including leash tugs, near hanging, accidental choking, anatomical obstruction to airflow and purposeful airway obstruction by people. The most common cause of NPPE was accidental choking (40% of cases). Dogs with an anatomical obstruction were older than 24 months. Hypoxemia with an increased alveolar-arterial gradient was common on presentation. The majority of thoracic radiographs (65.7%) showed an alveolar or interstitial pattern in the caudodorsal area as previously described in the literature. Oxygen therapy was administered to 33 (94.3%) dogs. Furosemide was administered to 18 (51.4%) dogs. Median length of hospitalization was 2 days (range 0-14). Twenty-eight (80%) dogs survived to discharge. Seven dogs were mechanically ventilated and only 2 of them (28.6%) 2 survived to discharge. Requirement for mechanical ventilation (p<0.001) was the only parameter associated with mortality.Conclusions: Most cases of NPPE occur in juvenile dogs. Different incidents associated with upper airway obstruction can produce an episode of NPPE.Choking on food or toys and near hanging have not been previously described in the veterinary literature as inciting causes of NPPE. The overall prognosis is good.

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