2019
DOI: 10.5935/abc.20190188
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Pulmonary Hypertension in General Cardiology Practice

Abstract: The finding of pulmonary hypertension (PH) by echocardiography is common and of concern. However, echocardiography is just a suggestive and non-diagnostic assessment of PH. When direct involvement of pulmonary circulation is suspected, invasive hemodynamic monitoring is recommended to establish the diagnosis. This assessent provides, in addition to the diagnostic confirmation, the correct identification of the vascular territory predominantly involved (arterial pulmonary or postcapillary). Treatment with speci… Show more

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Cited by 9 publications
(8 citation statements)
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References 63 publications
(72 reference statements)
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“…or supplement deficient antioxidants, in particular GSH and non-enzymatic antioxidants, including vitamins and trace elements; or trap the ROS directly [61]. Each of these categories of therapeutic approaches, most of which have ultimately had little or no success in treating pulmonary or pulmonary vascular disease [62]. But in parallel with the recommendation of one of these approaches there are problems concerning the chosen dose, with the half-life of the antioxidants supplemented; targeting of the appropriate tissue, organ or cells; type of patient and disease and according to the type of physiological disturbance of the oxidants [63].…”
Section: Discussionmentioning
confidence: 99%
“…or supplement deficient antioxidants, in particular GSH and non-enzymatic antioxidants, including vitamins and trace elements; or trap the ROS directly [61]. Each of these categories of therapeutic approaches, most of which have ultimately had little or no success in treating pulmonary or pulmonary vascular disease [62]. But in parallel with the recommendation of one of these approaches there are problems concerning the chosen dose, with the half-life of the antioxidants supplemented; targeting of the appropriate tissue, organ or cells; type of patient and disease and according to the type of physiological disturbance of the oxidants [63].…”
Section: Discussionmentioning
confidence: 99%
“…HP seja doença cardíaca esquerda e aumento da pressão hidrostática do sistema, a partir do átrio esquerdo. 14 O grupo III inclui pacientes com HP por doença pulmonar crônica, nos quais a gênese da enfermidade advém da perda do leito vascular pulmonar e da vasoconstrição hipóxica. 15 O grupo IV inclui pacientes com HP por embolia pulmonar crônica (HPTEC), e possui um manejo clínico distinto, além do escopo deste texto.…”
Section: Palavras-chaveunclassified
“…Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by vascular proliferation and endothelial remodeling that leads to an increase in pulmonary vascular resistance (PVR) and ultimately right heart failure and death. 1 Current pharmacological PAH treatment includes drugs from three distinct biochemical pathways: prostacyclin, endothelin, and nitric oxide. 2 These drugs can be used in monotherapy or combination, determined by the PAH etiology and the severity of the disease.…”
mentioning
confidence: 99%