Pulmonary hyalinizing granulomas in a patient with malignant lymphoma, with development nine years later of multiple myeloma and systemic amyloidosis

Drasin, Harry; Blume, Myron R.; Rosenbaum, Ernest; Klein, Harold P.

doi:10.1002/1097-0142(197907)44:1<215::aid-cncr2820440135>3.0.co;2-g

Cited by 27 publications

(11 citation statements)

References 19 publications

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“…PHG was associated with an infection in 19 cases (14.1 %). Tuberculosis was the most common (n= 14) 2,7,9,30,36,48,50,65,69,72,73,74 . One case of infection with the Human Immunodeficiency virus (HIV) was reported in association with PHG 65 .…”

Section: Pathological Conditions Associated With Phgmentioning

confidence: 99%

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Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

et al. 2016

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Pulmonary hyalinizing granuloma (PHG) is a rare disease characterized by single or multiple benign lung nodules mimicking lung neoplasma. Histologic analysis reveals homogenous hyaline lamellae, usually surrounded by collection of plasma cells, lymphocytes and histiocytes in a perivascular distribution. The clinical and radiological findings have been described in small series, but the long-term outcomes have rarely been reported. The objectives were to describe the clinical, radiological and outcomes of PHG in new cases and through a literature review. Patients with PHG were found by a multicenter search among French departments of internal medicine, pulmonology and anatomo-pathology. Review of the literature was made through the National Library of Medicine's MEDLINE database using keywords "hyalinizing granuloma." Five news cases and 135 cases of the literature were found. There were 82 men and 57 women, mean age at the diagnosis 44.6 years (15-83). Patients were frequently asymptomatic (n = 39, 27.4 %). The nodule was unique in 37 cases (28.9 %) and multiple in 91 cases (71.1 %). 18FDG PET scan revealed hypermetabolism of the nodule in 9/15 cases (60 %). A systemic disease was associated in 65 cases (mainly mediastinal and retroperitoneal fibrosis, autoimmune, tumoral or infectious disease or thromboembolism). The outcomes were evaluated in 73 patients when follow-up was available: 14 patients had a surgical resection of the nodule. Forty-five patients did not receive any immunosuppressive drug. Among these patients, 2 improved, 29 were stable and 14 worsened. Corticosteroids were used as a monotherapy in 19 patients and led to radiological improvement in 8 cases, stabilization in 8 cases and worsening in 3 cases. Five patients were treated with corticosteroids and at least one immunosuppressive drug and 4 patients improved. PHG is a rare benign disease, mimicking lung neoplasma, frequently associated with systemic diseases.

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Section: Pathological Conditions Associated With Phgmentioning

confidence: 99%

“…PHG was associated with an hematological disease in 5 cases (3.7 %): amyloidosis (n=2) 2,25 , multiple myeloma, lymphoma and amyloidosis (n=1) 7 , MALT lymphoma (n=1) 36 and Castleman's disease (n=1) 27 .…”

Section: Pathological Conditions Associated With Phgmentioning

confidence: 99%

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

et al. 2016

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“…The occurrence of small cell-type malignant disease, specifically lymphoma in this condition, has long been postulated, but only one case with PHG associated with stage IV diffuse lymphocytic lymphoma of the abdomen has been reported. 5 We present the first case of PHG and concomitant low-grade small lymphocytic B lymphoma of the lung.…”

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confidence: 97%

“…Since the first report by Engleman et al 1 in 1977, to the best of our knowledge, 61 cases of PHG have been reported in the English-language literature. [2][3][4][5][6][7] The nodules are typically benign in histology and clinical course, but slowly grow in size and number. Because of their behavior and to rule out a malignancy, biopsy is required to establish the primary diagnosis of PHG.…”

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confidence: 99%

Pulmonary Small Lymphocytic Lymphoma (Mucosa-Associated Lymphoid Tissue Type) Associated With Pulmonary Hyalinizing Granuloma

Ren

Raitz

Lee

et al. 2001

Chest

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“…This view is supported by findings in many other reports stating that myeloma was followed by an excess of NHL and leukemia. 1,4,[13][14][15][16][17][18][19][20] Standard incidence ratio for NHL after myeloma is 1.74 according some studies. 1 Morover, Onishi H et al, 26 reported a patient who developed NHL in remission of MM after 12 yr long treatment.…”

Section: Discussionmentioning

confidence: 99%

Patient with immunoproliferative disease and lung carcinoma: A case report

Radman

Sučić

Serventi‐Seiwerth

et al. 2005

Diagnostic Cytopathology

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There are a number of reports on collision occurrence of non-hematologic cancers and Non-Hodgkin's lymphoma (NHL) and multiple myeloma. In this report we present a case of patient with immunoproliferative disease, extramedullary plasmocytoma and NHL-lymphoplasmocytoid lymphoma (LPL) and squamous cell carcinoma of the lung. After diagnosis of extramedullary plasmocytoma cytostatic therapy was commenced and the patient was well. Five years after patient was clinically worse and diagnostic evaluation this time revealed lymphoplasmocytoid cells in bone marrow. Five months later malignant morphologically undifferentiated cells were found in bone marrow which were by immunocytochemistry established as CD38 positive. After the patient's death, disseminated NHL-LPL and squamous cell carcinoma of lung was confirmed. In the report, we compared clinical course and diagnostic findings of our patient with literature data. We have also discussed the possible relationship of multiple B-cell lymphoid tumors and squamous cell carcinoma concluding that multidiscplinary diagnostic tools are essential not only for carcinoma diagnosis and follow-up, but also for further understanding of carcinogenesis.

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Pulmonary hyalinizing granulomas in a patient with malignant lymphoma, with development nine years later of multiple myeloma and systemic amyloidosis

Cited by 27 publications

References 19 publications

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

Pulmonary Small Lymphocytic Lymphoma (Mucosa-Associated Lymphoid Tissue Type) Associated With Pulmonary Hyalinizing Granuloma

Patient with immunoproliferative disease and lung carcinoma: A case report

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