Patient with immunoproliferative disease and lung carcinoma: A case report

Radman, Ivo; Sučić, Mirna; Serventi‐Seiwerth, Ranka; Boban, Dubravka; Marković-Glamočak, Mirjana; Ries, Sunčica; Gjadrov-Kuveždić, Koraljka; Petković, Drazen; Jakić-Razumović, Jasminka; Ščukaneć-Špoljar, Mira; Seiwerth, Sven; Sučić, Zvonimir; Papa, J

doi:10.1002/dc.20176

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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“…A review of the literature shows only 15 reports of collision tumors in the neck. Of all collision tumors, only four prior case reports have described a collision of lymphoma and squamous cell carcinoma: two in the lung, one in the esophagus, and one in the urinary bladder (10)(11)(12)(13). No case report found a patient with a collision tumor occurring synchronously with another third distant malignancy.…”

Section: Contactmentioning

confidence: 99%

Management of a Novel Parotid Collision Tumor

et al. 2011

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INTRODUCTION DISCUSSION ABSTRACTEducational Objective: At the conclusion of this presentation, the participants should be able to define "collision tumor", describe a novel collision tumor of the parotid, and discuss the complexity in managing similar unexpected operative findings.Objectives: 1) To present a novel collision tumor of the parotid gland: concurrent squamous cell carcinoma and small cell lymphoma; and 2) to analyze the operative approach to collision tumors.Study Design: Case report. Abridged Case History:A 75 year old male with left ear lobule melanoma was concurrently found to have a right parotid mass. Pre-operative CT showed a right parotid mass and all FNA attempts were non-diagnostic. The patient was taken to the operating room for excision of the left ear melanoma, as well as for right superficial parotidectomy and right modified neck dissection. The operation was complicated by frozen pathology suggestive of a novel collision tumor.

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“…2 These entities have mostly been reported as case reports, or small case series with very few large studies done. 3-12 They can combine any type of lymphoma or leukemia with a non-hematological neoplasm of any solid organ including skin, all parts of the gastrointestinal tract, brain, lung, kidney, prostate, breast, and so on, and the non-hematological solid organ neoplasm may be a carcinoma or sarcoma. 3-12…”

Section: Introductionmentioning

confidence: 99%

Did I Miss It? Discovering Hidden Coexisting Hematological Neoplasms: A Single Institutional Review of 100 Collision Tumors

et al. 2018

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A collision tumor is defined as two histologically distinct tumor types identified at the same anatomic site. Hematolymphoid proliferative disorders (HLPDs), which coincide with non-hematological neoplasms, can mimic an immune response and can easily be overlooked as an immune reaction to a solid organ neoplasm, especially when low grade. In order to avoid a delay in the diagnosis of a HLPD during the workup for a non-hematological neoplasm, we identified a cohort of 100 cases with a HLPD diagnosis during the initial workup and treatment of a non-hematological neoplasm, or vice versa. Among the 100 collision tumors, the most common non-hematological neoplasms associated with a HLPD were from the colon (17%), breast (15%), and prostate (12%). The most commonly identified HLPDs were chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; 18%), diffuse large B-cell lymphoma (17%), follicular lymphoma (14%), marginal zone lymphoma (10%), acute myeloid leukemia (8%), and classical Hodgkin lymphoma (5%). Interestingly, in this cohort 5% of the low-grade HLPDs, all of them CLL/SLL, were missed at initial sign-out and subsequently required an addendum report. The other 95% of cases were reviewed or signed out by a hematopathologist before the report was finalized for the non-hematological neoplasm. In summary, high-grade hematological malignancies are less likely to be missed; however, low-grade coexisting HLPDs can be overlooked as a reactive immune response to a solid organ neoplasm. Therefore, it is important to keep in mind the existence of collision low-grade HLPDs before assuming the lymphoid infiltrates as an immunological response.

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Patient with immunoproliferative disease and lung carcinoma: A case report

Cited by 5 publications

References 35 publications

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Management of a Novel Parotid Collision Tumor

Did I Miss It? Discovering Hidden Coexisting Hematological Neoplasms: A Single Institutional Review of 100 Collision Tumors

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