Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura

Coleman, Christopher; Nassar, Aziza; McComb, Barbara L.

doi:10.4103/2156-7514.127835

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…PHG was associated with an auto-immune disease in 17 cases (12.1%): Grave's disease (n=2 including case 1) 43 , sarcoidosis (n=2 including case 4) 75 , cutaneous vasculitis (n=2) 2,6 , antiphospholipid syndrome (n=1) 60 , idiopathic thrombocytopenic purpura (n=3) 78,53,79 , multiple sclerosis (n=1) 28 , rheumatoid arthritis (n=1) 10 , Riedel disease (n=1) 16 , Sjögren syndrome (n=1) 82 , auto-immune thyroïditis (n=3) 16 , IgA nephropathy (n=1) 70 , hyperIgG4 syndrome (n=1) 75 and ANCA associated vasculitis (micro polyangéitis and granulomatosis with polyangeitis) (n=2) 2,82 . Mediastinal fibrosis and retroperitoneal fibrosis were found in respectively 19 2,10,12,13,14,19,22,23,43,59 (including cases #1 and 2) and 12 cases 1,2,9,13,23,25,40,47,51,52,54,62 .…”

Section: Pathological Conditions Associated With Phgmentioning

confidence: 99%

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

et al. 2016

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Pulmonary hyalinizing granuloma (PHG) is a rare disease characterized by single or multiple benign lung nodules mimicking lung neoplasma. Histologic analysis reveals homogenous hyaline lamellae, usually surrounded by collection of plasma cells, lymphocytes and histiocytes in a perivascular distribution. The clinical and radiological findings have been described in small series, but the long-term outcomes have rarely been reported. The objectives were to describe the clinical, radiological and outcomes of PHG in new cases and through a literature review. Patients with PHG were found by a multicenter search among French departments of internal medicine, pulmonology and anatomo-pathology. Review of the literature was made through the National Library of Medicine's MEDLINE database using keywords "hyalinizing granuloma." Five news cases and 135 cases of the literature were found. There were 82 men and 57 women, mean age at the diagnosis 44.6 years (15-83). Patients were frequently asymptomatic (n = 39, 27.4 %). The nodule was unique in 37 cases (28.9 %) and multiple in 91 cases (71.1 %). 18FDG PET scan revealed hypermetabolism of the nodule in 9/15 cases (60 %). A systemic disease was associated in 65 cases (mainly mediastinal and retroperitoneal fibrosis, autoimmune, tumoral or infectious disease or thromboembolism). The outcomes were evaluated in 73 patients when follow-up was available: 14 patients had a surgical resection of the nodule. Forty-five patients did not receive any immunosuppressive drug. Among these patients, 2 improved, 29 were stable and 14 worsened. Corticosteroids were used as a monotherapy in 19 patients and led to radiological improvement in 8 cases, stabilization in 8 cases and worsening in 3 cases. Five patients were treated with corticosteroids and at least one immunosuppressive drug and 4 patients improved. PHG is a rare benign disease, mimicking lung neoplasma, frequently associated with systemic diseases.

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Section: Pathological Conditions Associated With Phgmentioning

confidence: 99%

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

et al. 2016

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“…Positron emission tomography-CT may or may not reveal increased metabolic activity in PHG lesions, although it is useful in ruling out metastatic lesion. 5 …”

Section: Discussionmentioning

confidence: 99%

Solitary pulmonary hyalinising granuloma: a rare cause of pulmonary nodule

2017

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A pulmonary nodule is a common incidental finding on chest imaging, which includes a wide variety of differential diagnosis. Pulmonary hyalinising granuloma is a rare disease aetiology of pulmonary nodule(s). We report a 74-year-old female who was referred to the respiratory clinic with incidental finding of a solitary pulmonary nodule on chest X-ray. CT confirmed the presence of a 1.2 cm solitary pulmonary nodule in the left upper lobe with no lymphadenopathy. The patient underwent wedge resection, and histopathological examination of the lesion confirmed pulmonary hyalinising granuloma. In most previously reported cases, patients had multiple lesions on chest radiography. Solitary pulmonary lesion is an uncommon presentation of this clinical entity and only a few cases have been reported in the literature.

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“…The disease can exhibit slow growth and progressive enlargement or concomitant multiple nodules that can mimic metastatic disease [4].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Hyalinizing Granuloma: A Case Report

Amorim¹,

Silva²,

Filho³

2016

OJTS

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Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura

Cited by 10 publications

References 8 publications

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

Solitary pulmonary hyalinising granuloma: a rare cause of pulmonary nodule

Pulmonary Hyalinizing Granuloma: A Case Report

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