Pulmonary heart disease in Ibadan

Sub-Saharan Africa (SSA) is currently experiencing multiple burden of disease as a result of demographic and epidemiologic transition. This is occasioned rapid urbanization, unhealthy diets rich in fats and salt, western lifestyle and sedentary living. Heart failure (HF) has become a global public health issue. It is associated with high morbidity and mortality, frequent hospitalization and high economic cost. In SSA, HF is a disease of young and middle-aged adults with the attendant high disability-adjusted life years. This is unlike to the clinical profile and pattern of HF in high-income countries of North America, Western Europe and Japan where HF is a disease of the elderly. In addition, while ischaemic heart disease is the commonest aetiologic risk factor for HF in high income countries, HF in SSA is essentially non-ischaemic in origin. Hypertensive heart failure, dilated cardiomyopathy, rheumatic heart disease, pericardial diseases and HIV associated cardiomyopathy are the common risk factors. The chapter reviews the contemporary information on HF in SSA in terms of socio-demographic features, clinical characteristics, aetiological risk factors, management, prognosis and economic burden.

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“…At least six reports have looked at the aetiology of pulmonary heart disease in SSA [190][191][192][193][194][195].…”

Section: Pulmonary Heart Disease (Cor Pulmonale) and Pulmonary Hypertmentioning

confidence: 99%

Heart Failure in Sub-Saharan Africa

Adebiyi¹,

Sliwa‐Hähnle²

2019

Topics in Heart Failure Management

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“…SoFowoRA and IsAAcs [4] gave the first report of a plant extract, the aqueous extract of Zanthoxylum xanthoxyloides, reversing sickled cells in vitro. The ether fraction of the aqueous extract was later shown to possess this activity [5].…”

Section: Introductionmentioning

confidence: 99%

Biological Standardisation of Zanthoxylum Roots for Antisickling Activity

Adesanya¹,

Sofowora²

1983

Planta Med

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Antisickling activity reported in the aqueous extracts of Zanthoxylum xanthoxyloides (LAM.) WATER-MAN (= Fagara xanthoxyloides AM.) root has been demonstrated in roots of other species of Zanthoxylum. Z. gilletii (DE WILD.) WATERMAN (= Fagara macrophylla ENGL.) showed a much higher sickling re-versal potency than Z. xanthoxyloides. The unit of antisickling activity has been defined and a procedure is described for estimation of the potency of sickling reversal activity (p-hydroxy benzoic acid equivalent) in antisickling agents whether synthetic or natural in origin.

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“…[7] Others include pulmonary atherosclerosis, [4] kyphoscoliotic heart disease, [1,2] pulmonary fibrosis, [1,2] schistosomiasis, [8] and primary pulmonary hypertension. [1,2,4] Mortality associated with the disease is high. Over 70% die in less than 6 months after the onset of symptoms.…”

Section: Sirmentioning

confidence: 99%

“…The common causes of pulmonary hypertension/pulmonary heart disease includes the following: chronic obstructive airway disease, [1][2][3][4] pulmonary tuberculosis, [1][2][3][4] chronic suppurative lung disease, [1][2][3][4] connective tissue disease, [1,2,5,6] and sickle cell disease. [7] Others include pulmonary atherosclerosis, [4] kyphoscoliotic heart disease, [1,2] pulmonary fibrosis, [1,2] schistosomiasis, [8] and primary pulmonary hypertension.…”

Section: Sirmentioning

confidence: 99%

Pulmonary hypertension in Nigeria

Ogah¹

2010

PVRI Review

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Pulmonary heart disease in Ibadan

Cited by 13 publications

References 7 publications

Heart Failure in Sub-Saharan Africa

Heart Failure in Sub-Saharan Africa

Biological Standardisation of Zanthoxylum Roots for Antisickling Activity

Pulmonary hypertension in Nigeria

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