Biological Standardisation of Zanthoxylum Roots for Antisickling Activity

Adesanya, Saburi A.; Sofowora, Abayomi

doi:10.1055/s-2007-969873

Cited by 28 publications

(18 citation statements)

References 4 publications

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“…Add 2 to 3 drops of 0.1% FeCl 3 solution to extracts and fractions separately. Formation of black or bluish color shows the presence of phenol [19, 20]. …”

Section: Methodsmentioning

confidence: 99%

In VitroAntimicrobial and Antiprotozoal Activities, Phytochemical Screening and Heavy Metals Toxicity of Different Parts ofBallota nigra

Ullah

Ahmad

Ayaz

2014

BioMed Research International

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The study was done to assess the phytochemicals (flavonoids, terpenoids, saponins, tannin, alkaloids, and phenol) in different parts (root, stem, and leaves) of Ballota nigra and correlated it to inhibition of microbes (bacteria and fungi), protozoan (Leishmania), and heavy metals toxicity evaluation. In root and stem flavonoids, terpenes and phenols were present in ethanol, chloroform, and ethyl acetate soluble fraction; these were found to be the most active inhibiting fractions against all the tested strains of bacteria, fungi, and leishmania. While in leaves flavonoids, terpenes, and phenols were present in ethanol, chloroform, and n-butanol fractions which were the most active fractions against both types of microbes and protozoan (leishmania) in in vitro study. Ethanol and chloroform fractions show maximum inhibition against Escherichia coli (17 mm). The phytochemical and biological screenings were correlated with the presence of heavy metals in selected plant Ballota nigra. Cr was found above permissible value (above 1.5 mg/kg) in all parts of the plant. Ni was above WHO limit in B. nigra root and leaves (3.35 ± 1.20 mg/kg and 5.09 ± 0.47 mg/kg, respectively). Fe was above permissible value in all parts of B. nigra (above 20 mg/kg). Cd was above permissible value in all parts of the plant (above 0.3 mg/kg). Pb was above WHO limit (above 2 mg/kg) in all parts of Ballota nigra.

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“…Add 2 to 3 drops of 0.1% FeCl 3 solution to extracts and fractions separately. Formation of black or bluish color shows the presence of phenol [19, 20]. …”

Section: Methodsmentioning

confidence: 99%

In VitroAntimicrobial and Antiprotozoal Activities, Phytochemical Screening and Heavy Metals Toxicity of Different Parts ofBallota nigra

Ullah

Ahmad

Ayaz

2014

BioMed Research International

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“…Since then, biological and chemical assays have been developed for the estimation of antisickling agents in the roots of many Nigerian Zanthoxylum species (Elujoba and Sofowora, 1977;Adeoye, 1978;Adesanya, 1980). Very recently, in 1989, Osoba and his team studied the effect of the root extract of Zanthoxylum zanthoxyloides and some selected substituted benzoic acids on glucose-6-phosphate and 6-phosphogluconate dehydrogenases in HBSS red blood cells and found out that the antisickling fraction of the root of Z. zanthoxyloides, vanillic acid, p-hydroxy benzoic acid and p-fluoro benzoic acid possessed antisickling inhibitory activity at low concentrations Osoba et al, 1989).…”

Section: The Zanthoxylum Species In the Management Of Sickle-cell Dismentioning

confidence: 99%

The Nigerian <i>Zanthoxylum</i>: chemical and biological values

Adesina

2005

Afr. J. Trad. Compl. Alt. Med.

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The Nigerian Zanthoxylum is a common component of the rain forest vegetation of Southern Nigeria, and is represented by eleven species. A few of these species occur more abundantly in the savannah and dry forest vegetation of South-western Nigeria. The eleven Zanthoxylum species demonstrate very close similarities and relationships among themselves, and are identified as trees, erect shrubs or small trees, straggling or scandent shrubs or as a forest liane. Traditional healers throughout Nigeria have used species of the Zanthoxylum for the treatment of a wide range of disorders, including toothache, urinary and venereal diseases, rheumatism and lumbago. Metabolites isolated from Zanthoxylum species so far include alkaloids, aliphatic and aromatic amides, lignans, coumarins, sterols, carbohydrate residues etc. Some of the metabolites have shown cytotoxic, molluscicidal, anticonvulsant, antisickling, anaesthetic, antibacterial, anti-hypertensive and anti-inflammatory properties. A common feature of most, if not all, the species studied is the wonderful capacity to produce gums and volatile oils. These vary in composition and so show different properties. In this presentation, the author has discussed the chemistry of the various species examined to date. The focus has been on the local uses and commercial importance of the species, the values of the various metabolites in medicine and their general potential in drug development.

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“…That is why several African research groups focus on phytotherapy of sickle cell anemia (Adesanya and Sofowora, 1983;Ekeke and Shode, 1990;Adesanya et al, 1988;Fall et al, 1999;Iyamu et al, 2002;Akinsulie et al, 2005;Elekwa et al, 2005;Oduola et al, 2006;Ibrahim et al, 2007). In the same way, for several years, we have undertaken ethnobotanic surveys for identifying plants used in traditional medicine against anemia in general and SS anemia in particular (Mpiana et al, 2007a).…”

Section: Introductionmentioning

confidence: 99%