Pulmonary hazard identifications of Graphene family nanomaterials: Adverse outcome pathways framework based on toxicity mechanisms

Ding, Xiaomeng; Pu, Yuepu; Tang, Meng; Zhang, Ting

doi:10.1016/j.scitotenv.2022.159329

Cited by 6 publications

(3 citation statements)

References 89 publications

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“…Therefore, the biological characteristics of nanoparticles may change after biotransformation [ 177 ]. Ding et al studied the current status of pathological lung events induced by graphene and its derivatives, elaborated on the damage to different biological parts (molecules, cells, tissues, and organs) and the mechanistic relationship between different toxic endpoints, and further studied the possible mechanism of lung injury caused by graphene and its derivatives [ 178 ]. At present, there are fewer than 10 studies on the toxicity of graphene and its derivatives to mammals [ 178 ], so the true biosafety of graphene and its derivatives cannot be fully elaborated.…”

Section: Prospectsmentioning

confidence: 99%

“…Ding et al studied the current status of pathological lung events induced by graphene and its derivatives, elaborated on the damage to different biological parts (molecules, cells, tissues, and organs) and the mechanistic relationship between different toxic endpoints, and further studied the possible mechanism of lung injury caused by graphene and its derivatives [ 178 ]. At present, there are fewer than 10 studies on the toxicity of graphene and its derivatives to mammals [ 178 ], so the true biosafety of graphene and its derivatives cannot be fully elaborated. Further systematic studies on the metabolism, degradation, and excretion of graphene and its derivatives in mammals are needed to prepare for its further clinical application.…”

Section: Prospectsmentioning

confidence: 99%

See 1 more Smart Citation

Progress in the application of graphene and its derivatives to osteogenesis

Guo,

Cao,

Wei

et al. 2023

Heliyon

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Section: Prospectsmentioning

confidence: 99%

Section: Prospectsmentioning

confidence: 99%

Progress in the application of graphene and its derivatives to osteogenesis

Guo,

Cao,

Wei

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…One of the critical concerns is the ability of these materials to accumulate inside the body over time. Studies have shown that they can accumulate in the lungs and liver, but the long-term effects of this accumulation are not yet known [ 134 , 135 ]. Another hazard is the potential of these materials to harm cells and induces inflammation [ 136 ].…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Recent advances and mechanism of antimicrobial efficacy of graphene-based materials: a review

Bhatt¹,

Pathak²,

Punetha³

et al. 2023

J Mater Sci

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Graphene-based materials have undergone substantial investigation in recent years owing to their wide array of physicochemical characteristics. Employment of these materials in the current state, where infectious illnesses caused by microbes have severely damaged human life, has found widespread application in combating fatal infectious diseases. These materials interact with the physicochemical characteristics of the microbial cell and alter or damage them. The current review is dedicated to molecular mechanisms underlying the antimicrobial property of graphene-based materials. Various physical and chemical mechanisms leading to cell membrane stress, mechanical wrapping, photo-thermal ablation as well as oxidative stress exerting antimicrobial effect have also been thoroughly discussed. Furthermore, an overview of the interactions of these materials with membrane lipids, proteins, and nucleic acids has been provided. A thorough understanding of discussed mechanisms and interactions is essential to develop extremely effective antimicrobial nanomaterial for application as an antimicrobial agent. Graphical abstract

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Carbon-based composites in biomedical applications: a comprehensive review of properties, applications, and future directions

Kim,

Lee,

Rhee

et al. 2024

Adv Compos Hybrid Mater

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Carbon materials have emerged as a rapidly advancing category of high-performance materials that have garnered significant attention across various scientific and technological disciplines. Their exceptional biochemical properties render them highly suitable for diverse biomedical applications, including implantation, artificial joints, bioimaging, tissue and bone engineering, and scaffold fabrication. However, a more systematic approach is required to fully exploit the potential of carbon-based materials in the biomedical realm, necessitating extensive and collaborative research to address the existing challenges, which comprehensive long-term stability studies, the surface properties and investigate the toxicity of biomedical materials. This review paper aims to provide a comprehensive overview of carbon materials, elucidating their inherent advantages and highlighting their increasingly prominent role in biomedical applications. After a brief introduction of carbonaceous materials, we discuss innovative deposition strategies that can be utilized to artificially replicate desired properties, such as biocompatibility and toxicology, within complex structures. Further, this paper serves as a valuable resource to harness the potential of carbon materials in the realm of biomedical applications. Last, we conclude with a discussion on the significance of continuous exploration in propelling further advancements within this captivating field.

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Pulmonary hazard identifications of Graphene family nanomaterials: Adverse outcome pathways framework based on toxicity mechanisms

Cited by 6 publications

References 89 publications

Progress in the application of graphene and its derivatives to osteogenesis

Progress in the application of graphene and its derivatives to osteogenesis

Recent advances and mechanism of antimicrobial efficacy of graphene-based materials: a review

Carbon-based composites in biomedical applications: a comprehensive review of properties, applications, and future directions

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