Pulmonary haemorrhage in Weil’s disease

Boertjes, Emma; Hillebrand, Stefanie; Bins, Janneke Elisabeth; Oswald, Laurien

doi:10.1136/bcr-2018-227570

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…It carries a mortality rate of 5-15%. [8][9][10] Pulmonary hemorrhages are increasingly recognized as a major and potentially lethal complication of leptospirosis. Pulmonary involvement occurs in up to 70% of severe cases and predicts a poor outcome in which death can occur within 48 hours.…”

Section: Resident Discussionmentioning

confidence: 99%

44-year-old Man with Hemoptysis and Hypoxemic Respiratory Failure: A Case Report

McNeilly¹,

Williams²,

Bontempo³

et al. 2023

Clinical Practice and Cases in Emergency Medicine

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Introduction: Hemoptysis can be a highly alarming presentation in the emergency department (ED). Even seemingly minor cases may represent potentially lethal underlying pathology. It requires thorough evaluation and careful consideration of a broad differential diagnosis.Case Presentation: A 44-year-old man presented to the ED with a concern of hemoptysis in the setting of recent fever and myalgias.Discussion: This case takes the reader through how to approach the differential diagnosis and diagnostic work-up of hemoptysis in the ED setting and then reveals the surprising final diagnosis.

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Section: Resident Discussionmentioning

confidence: 99%

44-year-old Man with Hemoptysis and Hypoxemic Respiratory Failure: A Case Report

McNeilly¹,

Williams²,

Bontempo³

et al. 2023

Clinical Practice and Cases in Emergency Medicine

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“…These organisms are shed in the urine of animals to the environment from where humans are infected either directly or indirectly through infected soil or water. Humans are the incidental hosts for these organisms 4 . Leptospirosis can present with influenza like symptoms which is often self-limiting or can advance to a severe form which can affect the lung, liver or kidney 5 .…”

Section: Introductionmentioning

confidence: 99%

Leptospirosis, An Unusual Differential of Diffuse Alveolar Haemorrhage (DAH) in a Non-Tropical ITU- A Case Report

Majumder,

Thomas

2024

Int J Health Sci Res

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Severe leptospirosis has got very high mortality. Leptospirosis is overlooked in the UK and the confounders for low recognition, is partly due to low rate of incidence in this region, its protean manifestations, access to appropriate diagnostic tests, a broad differential for febrile illness or the lack of clinician’s awareness. A delay in diagnosis and treatment may lead to increased disease severity and mortality. In this case report, we present a 25-year-old gentleman who had pulmonary hemorrhage as the earliest sign of severe leptospirosis without severe renal or hepatic involvement, which is a rare occurrence by itself. Key words: Pulmonary haemorrhage, Leptospirosis

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“…Pathogenic leptospires penetrate the skin through abrasions and can rapidly migrate from the dermis, spreading through the bloodstream, to remain in different organs [ 3 – 5 ]. Human leptospirosis can present from subclinical infection to a severe syndrome with multiple organ failures requiring ICU and high mortality [ 6 – 8 ]. The disease is, in most cases, asymptomatic or mild, with a wide variety of clinical manifestations and flu-like symptoms (sudden onset of fever, headache, muscle pain or myalgia, and gastrointestinal involvement).…”

Section: Introductionmentioning

confidence: 99%

“…The case fatality rate for patients with severe leptospirosis is approximately 5% to 15% [ 12 ]. However, it can be greater than 50% for patients with pulmonary hemorrhagic syndrome, which occurs in 20–70% of patients with severe illness [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Demographic and clinical risk factors associated with severity of lab-confirmed human leptospirosis in Colombia, 2015–2020

Parra Barrera,

Bello Piruccini,

Rodríguez

et al. 2023

PLoS Negl Trop Dis

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Background Leptospirosis is a common zoonoses and is a major global public health threat. Most cases are mild, typically presenting as a non-specific acute febrile illness. However, leptospirosis can have life-threatening manifestations, including pulmonary hemorrhage syndrome, and acute kidney injury. In Colombia, notification and lab-confirmation of suspected human cases are mandatory. However, little is known about the demographic and clinical factors associated with severe leptospirosis, which could help to reduce clinical complications and mortality. Our aim was to identify risk factors associated with severe leptospirosis, intensive care unit (ICU) admission, and mortality in lab-confirmed cases in Colombia, 2015–2020. Methods and findings We analyzed 201 lab-confirmed human leptospirosis cases by microagglutination test. We used a logistic regression to identify the demographic and clinical risk factors associated with severe leptospirosis, admission to ICU, and death. Most leptospirosis confirmed cases occurred in men (85.6%); the mean age was 36.7 years. We classified severe cases (43.3%) by clinical manifestations as renal (29.9%) and liver (27.4%) failure, multiple-organ failure (24.4%), septic shock (24.4%), Weil syndrome (18.4%), pulmonary hemorrhage (18.4%), and meningitis (2.5%), admitted to the ICU (30.3%), and fatal (8.5%). Clinical conditions associated with severe leptospirosis were dyspnea (OR: 5.54; 95% CI: 1.46 to 20.98), tachycardia (OR:9.69; 95% CI: 15.96 to 58.8), and rash (OR: 10.25; 95% CI: 25.01 to 42.08). Conclusions We identified demographic characteristics and clinical symptoms associated with severe leptospirosis in Colombia. We hope these results can support clinicians in providing timely treatment to leptospirosis patients to avoid preventable medical complications or deaths.

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Pulmonary haemorrhage in Weil’s disease

Cited by 3 publications

References 20 publications

44-year-old Man with Hemoptysis and Hypoxemic Respiratory Failure: A Case Report

44-year-old Man with Hemoptysis and Hypoxemic Respiratory Failure: A Case Report

Leptospirosis, An Unusual Differential of Diffuse Alveolar Haemorrhage (DAH) in a Non-Tropical ITU- A Case Report

Demographic and clinical risk factors associated with severity of lab-confirmed human leptospirosis in Colombia, 2015–2020

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