Pulmonary Gas Exchange During Histamine-induced Bronchoconstriction in Asthmatic Subjects

Burke, Thomas V.; Küng, Markus; Burki, N. K.

doi:10.1378/chest.96.4.752

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…. 24 We found that in many children with airway obstruction, the shape of the postocclusion tracing during the first 40 ms was distorted due to the longer time required for PI,, to equilibrate with P,,,. It is preferable to wait as long as possible after the interruption to begin the extrapolation, but the potential onset of increased muscle activity limits the time span available.…”

Section: Discussionmentioning

confidence: 80%

“…I I . 24 cluded shutter between 150 and 250 ms, and closure times greater than 150 ms were not well tolerated by subjects. Therefore, we determined it best to use the values of P, at 40 and 80 ms postocclusion, late enough to allow PI,, to equilibrate with Pa,, in most of the subjects, but not so late that subjects would begin to breathe actively against the occlusion.…”

Section: Discussionmentioning

confidence: 97%

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Evaluation of the interrupter technique for the use of assessing airway obstruction in children

Carter

Stecenko

Pollock

et al. 1994

Pediatric Pulmonology

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The purpose of this study was to determine if the interrupter technique, a noninvasive method for measuring airflow resistance, could be used to assess airway obstruction in children. In 107 children (74 with asthma, 12 with cystic fibrosis, and 21 without lung disease) conductance (mostly of airways) measured with the interrupter technique (Gint) was correlated with both forced expiratory volume in 1 second (FEV1) and the forced expired flow rate between 25% and 75% of vital capacity (FEF25–75. In addition, 17 children with significant airway obstruction due to asthma also had airway resistance measured by body plethysmography (Raw) before and after treatment. Resistance and conductance measurements made with the interrupter technique were subdivided into inspiratory (Rint‐insp, Gint‐insp) and expiratory (Rint‐exp Gint‐exp) values. In the 107 children, a high degree of linear correlation was found between Gint‐exsp and FEV1 for Gint‐insp, r = 0.77 (P < 0.001), and for r = 0.76 (P < 0.001). There was also good linear correlation between Gin, and FEF25–75 for r = 0.70 (P < 0.001), and for Gint‐insp, r = 0.67 (P < 0.001). In the 17 asthmatic children who were tested before and after treatment of their airway obstruction, Rint correlated highly with Raw; for Rint‐exp, r = 0.91 (P < 0.001), and for Rint‐insp, r = 0.83 (P < 0.001). The pre‐ to posttreatment changes in R, and Raw were similar. We conclude that the interrupter technique can be used to assess changes in airway obstruction, but normal values must be established and further investigation is required before the complete extent of its clinical utility will be known. Pediatr Pulmonol. 1994; 17:211–217. © 1994 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 97%

Evaluation of the interrupter technique for the use of assessing airway obstruction in children

Carter

Stecenko

Pollock

et al. 1994

Pediatric Pulmonology

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“…It is appealing for its obvious relevance to the clinical state of the patient. Changes in Ptc,O 2 during bronchial obstruction probably reflect ventilation-perfusion mismatch [41,42]. These are generally assumed to reflect changes in the peripheral parts of the airways [43].…”

Section: Discussionmentioning

confidence: 99%

Lung function measurement in awake young children

Bisgaard¹,

Klug²

1995

Eur Respir J

251

208

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Keywords: interrupter lung function oscillometry spirometry transcutaneous measurements of oxygen whole body plethysmography young children Received: December 14 1994 Accepted after revision August 28 1995 This study was supported by grants from the Danish Ministry of Health and from Astra-Draco, Lund, Sweden.Eur Respir J, 1995, 8, 2067-2075 DOI: 10.1183 ) were compared with concomitant measurements of specific airway resistance (sRaw) and forced expiratory volume in one second (FEV1) by whole body plethysmography and spirometry, respectively, during methacholine challenge in 21 young children aged 4-6 yrs, with suspected asthma. Measurements with each technique were repeated after each challenge step. A special face-mask was developed with an integrated mouthpiece which ensured mouth breathing during the measurements.The order of sensitivity of the techniques to assess methacholine-induced changes in lung function was ZIOS > sRaw > Ptc,O 2 > FEV1 > Rint. ZIOS was significantly more sensitive than all subsequent methods, and Ptc,O 2 was significantly more sensitive than FEV1. ZIOS, sRaw and Rint, but not Ptc,O 2 and FEV1, detected the subclinical increase in bronchial muscle tone in the children during baseline, which was revealed by the significantly reduced airway obstruction after inhalation of a b b b b b 2 -agonist as compared to baseline.It is concluded that ZIOS, Rint and Ptc,O 2 change in parallel with sRaw and FEV1 and with a comparable sensitivity during simultaneous measurements of the response to methacholine in young children aged 4-6 yrs. This implies that ZIOS, Rint and Ptc,O 2 provide convenient indices of changes in lung function. Their combined use will be useful for monitoring airway diseases of young children.

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“…Therefore, relation of ventilation/ perfusion is an important indicator in interpreting of the rate of the bronchoconstriction, respectively in interpreting of the role of adrenergic system in the tonus of the airways smooth musculature in patients with bronchial asthma (15).…”

Section: Introductionmentioning

confidence: 99%

Importance of the Adrenergic Nerve System in the Response of Gases in the Arterial Blood Following the Provoked Bronchospasm

Islami

Veseli²,

Behluli³

et al. 2012

Med Arh

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Following the inhalation of the beta-blocker-Propranolol (20 mg/ml-aerosol), there was an evident decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2. Beta2-adrenergcic stimulator-Hexoprenaline (2 inh x 0.2 mg), shows an protective effect in the decrease of pO2 (p < 0.05) following the bronchoconstriction being provoked by Propranolol. Alpha2-adrenergic blocker-Tolazoline (20 mg/ml-aerosol), has not shown a protective action in the bronchoconstriction caused with propranolol, therefore significant decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2 appeared. This shows that stimulation of beta2-adrenergic receptor has protective action in changes of the respiratory gases. Meantime, blocker of the alpha2-adrenergic receptor (Tolazoline) has not shown a protective action in changes of the respiratory gases.

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Pulmonary Gas Exchange During Histamine-induced Bronchoconstriction in Asthmatic Subjects

Cited by 16 publications

References 30 publications

Evaluation of the interrupter technique for the use of assessing airway obstruction in children

Evaluation of the interrupter technique for the use of assessing airway obstruction in children

Lung function measurement in awake young children

Importance of the Adrenergic Nerve System in the Response of Gases in the Arterial Blood Following the Provoked Bronchospasm

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