Pulmonary functions in pseudoexfoliation syndrome

Batur, Muhammed; Seven, Erbil; Tanrikulu, M. Azra; Ekin, Selami; Tekın, Serek; Yaşar, Tekin

doi:10.1111/crj.12903

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Literature review of positive risk factors for XFS in general [Tables 5 - 7 ][ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 ] and XFS in young subjects [ Table 8 ][ 82 83 84 85 86 87 88 89 90 91 …”

Section: Resultsmentioning

confidence: 99%

“…In the Lebanese cohort under investigation, XFS was associated with advanced age, glaucoma, habitual ocular rubbing, and longer time for cataract surgery. While advanced age [ Table 6 ],[ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] glaucoma [ Table 5 ],[ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 ] and longer surgery duration[ 100 ] are well established risk factors for XFS [ Table 5 ],[ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 <...>…”

Section: Discussionmentioning

confidence: 99%

“…Asthma and abnormal pulmonary function tests (obstructive airway disease) have been associated with XFS [ Table 6 ]. [ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] Batur et al . [ 66 ] in 60 patients with XFS without pulmonary disease detected a significant decline in pulmonary function tests versus 52 controls matched for age, gender, and smoking history.…”

Section: Discussionmentioning

confidence: 99%

“…[ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] Batur et al . [ 66 ] in 60 patients with XFS without pulmonary disease detected a significant decline in pulmonary function tests versus 52 controls matched for age, gender, and smoking history. Similarly, in the Reykjavik Eye Study, a population-based study involving 1045 subjects (108 XFS) followed for 5 years, asthma was significantly associated with XFS (odds ratio 1.91; [95% confidence interval 1.00–3.62]) by multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

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A case–cohort study of exfoliation risk factors and literature review

Mansour

Konstas

Mansour

et al. 2021

Middle East Afr J Ophthalmol

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The purpose of the study is to evaluate the risk factors associated with exfoliation in a case-cohort setting and literature review. This single-center, prospective, case-cohort study was carried out from January 2010 to April 2020 on patients operated for cataract surgery by a single surgeon in Lebanon. Forty-nine consecutive patients with exfoliation syndrome (XFS) and 62 consecutive control patients were identified and further investigated for selected systemic (diabetes mellitus, systemic hypertension, asthma, or atopy) and ocular variables (baseline vision, severity of nuclear sclerosis, glaucoma, eye rubbing, history of dry eye, or allergic eye disease). The mean baseline Snellen visual acuity was 20/283 in XFS versus 20/145 in control cases ( P = 0.012). XFS also demonstrated significantly denser nuclear sclerosis than controls ( P = 0.00958). By univariate analysis, allergic conjunctivitis (15 [30.6%] vs. 2 [3.2%]; P < 0.001), dry eye (20 [40.8%] vs. 13 [21.0%]; P = 0.0133), and habitual rubbing of the eyes (33 [67.3%] vs. 19 [30.6%]; P < 0.001) were associated with the presence of XFS. Habitual ocular rubbing was closely associated with allergic conjunctivitis (odds ratio [OR] = 13.0; 95% confidence interval [CI]: 2.8–58.8; P = 0.032). After multivariable analysis, the following variables showed significant results: glaucoma (OR = 34.5; 95% CI: 4.4–250; P = 0.010), duration of surgery (OR = 5.6; 95% CI 2.43–12.9; P < 0.001), and habitual ocular rubbing (OR = 4.42; 95% CI: 1.97–9.90; P = 0.029). This study shows a novel potential correlation between eye rubbing and XFS in a Lebanese cohort. Chronic eye rubbing induces or may exacerbate preexistent zonular damage in subjects with XFS, hence the need to better manage concurrent ocular surface disorder in these patients.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A case–cohort study of exfoliation risk factors and literature review

Mansour

Konstas

Mansour

et al. 2021

Middle East Afr J Ophthalmol

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“…10 A strong positive association was found between self-reported asthma and PEX (p<0.001) in our study, with asthmatics having seven times greater odds of developing PEX than nonasthmatics. Batur et al, reported poorer pulmonary functions in individuals with PEX as compared to those without, 18 while Taylor et al found an increased risk of chronic obstructive pulmonary disease (COPD) diagnosis in individuals with PEX. 19 It was hypothesized that impaired elastogenesis associated with LOXL1 mutations in PEX may alter the repair processes in the lung, leading to pulmonary damage, especially after an insult such as cigarette smoking.…”

Section: Discussionmentioning

confidence: 99%

The association between ethnicity, environmental and lifestyle factors and chronic disease in the development of pseudoexfoliation syndrome

Arif

Khan²,

Nauman³

et al. 2021

Pak J Med Sci

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Objectives: To determine the association between ethnicity, environmental factors, lifestyle factors, chronic diseases and pseudoexfoliation syndrome (PEX). Methods: A case control study conducted at four major hospitals in Pakistan from January to November 2019, with 241 cases and 294 controls, aged ≥ 40 years, who were administered a questionnaire assessing demographics, lifestyle factors, chronic diseases and ethnicity. Multivariate binary logistic regression was applied to calculate the odds ratio between cases and controls. Results: PEX was found to be positively associated with ethnicity (p<0.001), time spent outdoors (p<0.001), educational status (p<0.001), asthma (p<0.001), mean age (p<0.001), daily tea intake (p=0.003), weighted maximum temperature (p<0.001) and weighted mean temperature (p=0.004). Poor association was found with weighted latitude (p=0.526) and weighted minimum temperature (p=0.079). Odds ratios for patients with asthma (OR=7.366, regression coefficient=1.993, p<0.001) Pathan ethnicity (OR=1.616, regression coefficient=0.48, p=0.016) and mean weighted temperature (OR=0.907, regression coefficient-0.097, p=0 0.000) were significant in diagnosed cases of PEX. Conclusion: Individuals with Pathan ethnicity and asthmatics should be made aware of the risk of developing PEX and the importance of periodic screening. Limiting exposure to sunlight and cold and reducing the intake of tea may help in reducing in the chances of developing PEX. doi: https://doi.org/10.12669/pjms.37.2.2216 How to cite this:Arif SA, Khan MI, Nauman F, Arif MA. The association between ethnicity, environmental and lifestyle factors and chronic disease in the development of pseudoexfoliation syndrome. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2216 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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