Nasal mucociliary clearance and hearing loss in pseudoexfoliation syndrome

Muhafız, Ersin; Çetin, Yaser Said

doi:10.1007/s00405-020-06461-2

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…In contrast with the above-mentioned results, Muhafiz et al did not find any significant difference in hearing loss prevalence and hearing thresholds at 0.25, 0.5, 1, 2, 4, 6 and 8 kHz between XFS and controls ( p > 0.05) [ 71 ]. Additionally, Tryggvason et al examined hearing loss in 158 patients with XFS/XFG, 95 POAG and 123 controls, and no significant differences were found at either low or high frequencies between groups after controlling for age, sex and possible confounders [ 72 ].…”

Section: Resultsmentioning

confidence: 84%

Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review

Meliante,

Piccotti,

Tanga

et al. 2024

JCM

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Purpose: To investigate the relationship between glaucoma, pseudoexfoliation and hearing loss (HL). Methods: A systematic literature search following PRISMA guidelines was conducted using the PubMed, Embase, Scopus and Cochrane databases from 1995 up to 28 August 2023. Results: Thirty studies out of the 520 records screened met the inclusion criteria and were included. Most articles (n = 20) analysed the association between pseudoexfoliation syndrome (XFS) and HL, showing XFS patients to have higher prevalence of sensorineural hearing loss (SNHL) at both speech frequencies (0.25, 0.5, 1 and 2 kHz), and higher frequencies (4 and 8 kHz) compared to controls in most cases. No significant differences in prevalence or level of HL between XFS and pseudoexfoliative glaucoma (XFG) were detected in most studies. Eight articles analysed the relationship between primary open-angle glaucoma (POAG) and HL. Overall, a positive association between the two conditions was highlighted across all studies except for two cases. Similarly, articles focusing on NTG and HL (n = 4) showed a positive association in most cases. The role of autoimmunity and, in particular, the presence of antiphosphatidylserine antibodies (APSA) in patients with NTG and HL suggested an underlying autoimmune or vascular mechanism contributing to their pathogenesis. Only one study analysed the relationship between angle-closure glaucoma (ACG) and HL, showing higher incidence of ACG in patients with SNHL compared to normal hearing controls. Conclusions: Most studies detected an association between XFS and HL as well as POAG/NTG/ACG and HL, suggesting the presence of a similar pathophysiology of neurodegeneration. However, given the strength of the association of XFS with HL, it remains unclear whether the presence of XFG is further associated with SNHL. Further research specifically targeted to assess the correlation between glaucoma, XFS and HL is warranted to provide a more comprehensive understanding of this association.

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Section: Resultsmentioning

confidence: 84%

Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review

Meliante,

Piccotti,

Tanga

et al. 2024

JCM

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“…Another study was excluded due to data being presented as graphs only, rather than meta‐analyzable numbers. However, the study found no difference in HL between patients with XFS and controls 57 . Two studies showed high a likelihood of reporting the same patients; both studies were included because they provided different types of primary outcomes data 46,47 .…”

Section: Resultsmentioning

confidence: 94%

“…However, the study found no difference in HL between patients with XFS and controls. 57 Two studies showed high a likelihood of reporting the same patients; both studies were included because they provided different types of primary outcomes data. 46,47 Patient data for these two studies were not doublecounted in any pooled statistics or meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta‐Analysis

et al. 2022

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Objective: To determine if exfoliation syndrome (XFS) is associated with hearing loss (HL) or vestibular dysfunction. Data Sources: PubMed, Scopus, CINAHL, and Cochrane Library through April 1, 2022. Review Methods: Two reviewers independently screened abstracts, selected articles for inclusion, and extracted data. Studies included for qualitative analysis conducted audiometric, tympanometric, or vestibular evaluations on all subjects.Results: Twenty-one publications (1148 patients with XFS and 1212 controls) were included in the systematic review, and 16 publications (968 patients with XFS and 1147 controls) in the meta-analysis. Greater severity of HL was seen for patients with XFS compared to controls across all frequencies (odds ratio [OR] 8.8 [7.3-10.2]). Patients with XFS were more likely to have moderate to profound sensorineural HL ), and less likely to have none to mild HL (OR 0.34 [0.17-0.67]) or no HL (OR 0.37 [0.28-0.50]). Three studies found patients with XFS had lower tympanometric peaks. Two studies found that abnormal vestibular testing results could be more common for patients with XFS.Conclusions: HL is associated with XFS. A sensorineural component to HL is confirmed, and mixed HL is possible. Given the high prevalence and infrequent diagnosis of XFS, the authors hypothesize that the current understandings of presbycusis might be improved by further investigation in XFS.

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