Pulmonary Function Studies in Ex-Heroin Users

Camargo, Gustavo Arantes; Colp, Charlotte

doi:10.1378/chest.67.3.331

Cited by 28 publications

(5 citation statements)

References 11 publications

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“…The above indicates that a large proportion of stable MMT patients have abnormal resting gas exchange including abnormal ventilation/perfusion, the cause of which is unclear. Previous studies of D L CO in similar patient groups by Camargo et al, 13 Overland et al 14 and Miller et al 5 had found the mean D L CO of 81%, (13), 79.8% (14) and 80% (men) and 84% (women) (five) of nonsmoking normative data. However, they did not report the number of patients with D L CO outside the 95% CI range.…”

Section: Discussionmentioning

confidence: 81%

“…These results are consistent with obstructive ventilatory defect and are in keeping with those of previous studies. 13,33 Camargo studied 22 MMT patients and found four patients with abnormal vital capacity (VC) and total lung capacity (TLC). 13 Santiago examined 14 MMT patients and found that they had mild reduction of FEV 1 /FVC ratio (range 70 -90%).…”

Section: Discussionmentioning

confidence: 99%

“…13,33 Camargo studied 22 MMT patients and found four patients with abnormal vital capacity (VC) and total lung capacity (TLC). 13 Santiago examined 14 MMT patients and found that they had mild reduction of FEV 1 /FVC ratio (range 70 -90%). 33 Miller et al concluded that the mildly abnormal FEV 1 and FVC results noted in the MMT patients they studied were due to cigarette smoking.…”

Section: Discussionmentioning

confidence: 99%

“…7 -12 Only three studies have reported respiratory function of stable patients in MMT and these have shown conflicting results. 5,13,14 To our knowledge only one study has assessed electrocardiogram (ECG) in stable MMT patients. 15 No studies have systematically assessed resting respiratory function, ECG, echocardiography and chest X-ray (CXR) in stable MMT patients.…”

Section: Introductionmentioning

confidence: 99%

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Cardiorespiratory function in stable methadone maintenance treatment (MMT) patients

et al. 2004

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Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory function on 50 stable MMT patients (25 males, 25 females). Forty-six MMT patients were current tobacco smokers, 19 were current cannabis users and none were currently using opioids other than prescribed methadone. We defined abnormalities of respiratory function as those results outside the 95% confidence interval of reference values for normal subjects adjusted for age, weight, height and sex. Thirty-one (62%) MMT patients had reduced carbon monoxide transfer factor (D(L)CO); 17 (34%) had elevated single breath alveolar volume (V(A)) and 43 (86%) had a reduced D(L)CO/V(A) ratio. Six patients (12%) had reduced FEV1; one (2%) had reduced FVC; and nine (18%) had an obstructive ventilatory defect. Ten (20%) patients had PaCO2 higher than 45 mmHg and 14 (28%) had alveolar to arterial oxygen gradient (A-aPO2) higher than 15 mmHg. CXR, Echocardiography and ECG showed no significant abnormalities. We conclude that stable MMT patients have abnormalities of resting respiratory function which may be due to ongoing tobacco cigarette and current or past cannabis smoking.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiorespiratory function in stable methadone maintenance treatment (MMT) patients

et al. 2004

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“…18,37 Ex-heroin users usually have normal pulmonary function studies except for a decreased diffusing capacity. 9,37 In ex-heroin addicts receiving maintenance methadone (excluding those with chronic bronchitis), a significant reduction in the single-breath diffusing capacity is the only pulmonary function abnormality. It was suggested that the abnormal diffusing capacity resulted from a reduction of the pulmonary capillary bed secondary to vascular or interstitial granulomatosis.…”

Section: Pulmonary Function Studiesmentioning

confidence: 99%