Pulmonary function, muscle strength, and quality of life have differed between chronic kidney disease patients and healthy individuals

Rezende, Patricia de Souza; Andrade, Francini Porcher; Borba, Carolina Ferraro dos Santos; Rovedder, Paula Maria Eidt

doi:10.1111/1744-9987.13714

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…39 Compared to healthy controls, patients with chronic kidney disease exhibit a significant decline in lung function. 40,41 Studies in chronic obstructive pulmonary disease have shown that respiratory muscle training improves lung function and increases respiratory muscle strength. 42 Similar benefits were evident in this review, with improved lung function assessed by forced expiratory volume at 1 second and forced vital capacity.…”

Section: Discussionmentioning

confidence: 99%

Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

et al. 2022

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Objective This systematic review and meta-analysis aimed to evaluate the effect of respiratory muscle training on respiratory muscle strength, lung function, cardiopulmonary fitness, and quality of life for chronic kidney disease patients. Methods PubMed, Embase, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials published randomized controlled trials that evaluated the effect of respiratory muscle training for chronic kidney disease patients from inception to December 2021, and rerun on September 2022. The quality of included studies was evaluated according to the Cochrane Collaboration's risk of bias tool-2. The outcomes were analyzed as mean differences with a fixed/random effect model. The strength of evidence was evaluated with the Grading of Recommendation, Assessment, Development, and Evaluation approach. Results Eleven randomized controlled trials were included. All but two of the studies were in hemodialysis patients. The follow-up time range was 4 to 12 weeks. Compared to controls, respiratory muscle training significantly improved maximal expiratory pressure (mean difference = 17.36, p = 0.013), maximal inspiratory pressure (mean difference = 18.26, p = 0.002), forced expiratory volume at 1 second (mean difference = 0.20, p= 0.020), forced vital capacity (mean difference = 0.26, p = 0.008), but not for 6-minute walk test (mean difference = 39.85, p= 0.138). Conclusions As a non-pharmacological therapy, respiratory muscle training can effectively improve maximal expiratory pressure, maximal inspiratory pressure, forced expiratory volume at 1 second, and forced vital capacity in patients with chronic kidney disease and is safe for such populations.

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Section: Discussionmentioning

confidence: 99%

Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

et al. 2022

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“…CKD represents not only a comorbidity of COPD but is also an independent factor for the exacerbation of COPD and increased mortality in COPD patients. In fact, CKD patients have lower pulmonary function, respiratory and peripheral muscle strength values compared to the general population, which reflects negatively in the quality of life [ 27 ].…”

Section: Chronic Obstructive Pulmonary Disease (Copd) and Ckdmentioning

confidence: 99%

Lung Dysfunction and Chronic Kidney Disease: A Complex Network of Multiple Interactions

Gembillo

Calimeri

Tranchida

et al. 2023

JPM

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Chronic kidney disease (CKD) is a progressive disease that affects > 10% of the total population worldwide or >800 million people. CKD poses a particularly heavy burden in low- and middle-income countries, which are least able to cope with its consequences. It has become one of the leading causes of death worldwide and is one of the few non-communicable diseases where the number of related deaths has increased over the last two decades. The high number of people affected, and the significant negative impact of CKD should be a reason to increase efforts to improve prevention and treatment. The interaction of lung and kidney leads to highly complex and difficult clinical scenarios. CKD significantly affects the physiology of the lung by altering fluid homeostasis, acid-base balance and vascular tone. In the lung, haemodynamic disturbances lead to the development of alterations in ventilatory control, pulmonary congestion, capillary stress failure and pulmonary vascular disease. In the kidney, haemodynamic disturbances lead to sodium and water retention and the deterioration of renal function. In this article, we would like to draw attention to the importance of harmonising the definitions of clinical events in pneumology and renal medicine. We would also like to highlight the need for pulmonary function tests in routine clinical practise for the management of patients with CKD, in order to find new concepts for pathophysiological based disease-specific management strategies.

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Association between pulmonary function and rapid kidney function decline: a longitudinal cohort study from CHARLS

Han,

Xu,

Wang

2024

BMJ Open Resp Res

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BackgroundPulmonary function has been reported to be associated with chronic kidney disease. However, the relationship between lung function and rapid kidney function decline remains unclear.MethodsParticipants aged ≥45 years with complete data from the 2011 and 2015 interviews of the China Health and Retirement Longitudinal Study (CHARLS) were included. Lung function, assessed by peak expiratory flow (PEF), and kidney function, assessed by estimated glomerular filtration rate (eGFR), were tested at the baseline and endpoint surveys. Rapid kidney function decline was defined as a decrease in eGFR ≥3 mL/min/1.73 m²/year, and ΔeGFR represented the difference between baseline and endpoint eGFR. Multivariate logistic regression models and linear regression models were employed to evaluate the association between PEF and the risk of rapid eGFR decline, as well as the correlation between PEF and ΔeGFR.ResultsA total of 6159 participants were included, with 1157 (18.78%) individuals experiencing a rapid decline in eGFR. After adjusting for potential covariates, higher baseline PEF (Quartile 4 vs Quartile 1, OR=0.95, 95% CI 0.92 to 0.98) and elevated PEF % predicted (OR=0.96, 95% CI 0.94 to 0.99) were found to be associated with a lower risk of rapid eGFR decline. ΔeGFR decreased by 0.217 and 0.124 mL/min/1.73 m² for every 1 L/s increase in baseline PEF (β (95% CI): −0.217 (−0.393 to –0.042)) and 10% increase in PEF % predicted (β (95% CI): −0.124 (−0.237 to –0.011)), respectively. During the follow-up period, ΔeGFR decreased as PEF increased over time among participants in Quartile 1 (β per 1 L/s increase in ΔPEF=−0.581, 95% CI −1.003 to –0.158; β per 10% increase in ΔPEF % predicted=−0.279, 95% CI −0.515 to –0.043).ConclusionsHigher PEF was associated with a slower longitudinal eGFR decline in middle-aged and older adults.

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Pulmonary function, muscle strength, and quality of life have differed between chronic kidney disease patients and healthy individuals

Cited by 6 publications

References 25 publications

Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

Lung Dysfunction and Chronic Kidney Disease: A Complex Network of Multiple Interactions

Association between pulmonary function and rapid kidney function decline: a longitudinal cohort study from CHARLS

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