Pulmonary Function in Uremic Patients on Long‐term Hemodialysis

Karacan, Özgür; Tutal, Emre; Uyar, Murathan; F, Öner Eyüboğlu; Sezer, Sıren; Özdemir, F.N.

doi:10.1081/jdi-120039526

Cited by 19 publications

(30 citation statements)

References 14 publications

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“…They evaluated CKF patients who underwent CAPD and found decreased MIP in patients with CKF (59.6% of predicted values), compared with controls (82.7% of predicted values). Other authors 14,33,35 have also found results similar to those found in the present study. There is a consensus that respiratory muscle strength is decreased, and the pathogenesis of this condition is similar to what is observed in peripheral muscles.…”

Section: Discussionsupporting

confidence: 82%

“…However, the present authors propose that the main disorders associated with these results are the following: chronic and often subclinical pulmonary edema; decreased serum albumin with consequent water and protein imbalance in the microcirculation; interstitial fibrosis and calcification of the lung parenchyma and bronchial tree; recurrent infections; and alveolitis and fibrosis due to corticosteroid therapy in immunosuppressed patients. Studies that evaluate lung function in patients with CKF undergoing dialysis and after kidney transplantation have described results similar to those found in the present study and help to explain the lesion mechanisms 14,[31][32][33] .…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Cury¹,

Brunetto²,

Aydos

2010

Rev. bras. fisioter.

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Objective: To evaluate lung function and functional capacity in patients with chronic kidney failure (CKF) undergoing dialysis and in patients after kidney transplant. Methods: Seventy-two participants were evaluated: 32 patients with CKF on dialysis (DG) for at least six months, ten patients who had kidney transplants (TG) at least six months earlier, and 30 healthy subjects as a control group (CG). all groups were evaluated using spirometry, with maximum inspiratory pressure (mIP) and maximum expiratory pressure (mEP), and using the six-minute walking test (6mWT). The SPSS 12.0 software was used for statistical analysis, with a minimum significance level of α<0.05. Results: There was a decreased lung function in the DG for FVC, FEV1, mVV, VC, mIP and mEP, and decreased FEV1 and mVV in the TG compared to the CG (one-way aNOVa/Fisher's post-hoc; p<0.01). There was also an association (chi-square) between decreased mIP and belonging to the DG ‫,5.0=ג(‬ p<0.001), between lower performance in the 6mWT for the DG and TG (p<0.01) compared to the CG (one-way aNOVa/Fisher's post-hoc), and between mIP and mEP (Pearson's coefficient; r=0.752; p<0.01). Conclusions:Patients with CKF undergoing dialysis showed impaired functional capacity and lung function that were not completely reverted in the kidney transplant patients.Key words: dialysis; kidney transplant; spirometry; respiratory muscles; functional capacity. ResumoObjetivo: avaliar a função pulmonar e a capacidade funcional em pacientes com insuficiência renal crônica (IRC) em hemodiálise e em pacientes após transplante renal. Métodos: Foram avaliados 72 indivíduos, sendo 32 pacientes com IRC em hemodiálise (GD) há mais de 6 meses, 10 pacientes transplantados renais (GT) há, pelo menos, 6 meses e 30 sujeitos saudáveis para grupo controle (GC). Todos os grupos foram avaliados utilizando espirometria, pressões inspiratória (PImax) e expiratória (PEmax) máximas e teste da caminhada em seis minutos (TC6min). Para análise estatística, foi utilizado o programa SPSS 12.0, com nível mínimo de significância α<0,05. Resultados: Foram encontrados resultados estatisticamente significativos (p<0,01) para: diminuição da função pulmonar no GD para Capacidade vital forçada (CVF), Volume expirado forçado (VEF1), Ventilação voluntária máxima (VVm), Capacidade vital (CV), PImax, PEmax e, para o GT, diminuição do VEF1 e VVm, quando comparados ao GC (aNOVa uma via/post hoc Fischer); associação (qui-quadrado) entre diminuição da PImax e pertencer ao GD ‫,5,0=ג(‬ p<0,001); menor desempenho no TC6min no GD e GT (p<0,01) quando comparados ao GC (aNOVa uma via/post hoc Fischer). Encontrou-se correlação significativa (coeficiente de Pearson) entre PImax e PEmax (r=0,752, P<0,01). Conclusões: Pode-se concluir que existem alterações na capacidade funcional e na função pulmonar do paciente com IRC em hemodiálise, as quais são indicativas de prejuízos funcionais que não se apresentam completamente revertidos no paciente transplantado renal.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 78%

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Cury¹,

Brunetto²,

Aydos

2010

Rev. bras. fisioter.

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“…(4,5) In another study, MIP was also found to be decreased after hemodialysis sessions. (19) The results of those studies were not replicated in our study, possibly due to differences in duration of hemodialysis. In comparison with the study mentioned above, (19) for example, the duration of hemodialysis (85 ± 41 months) was considerably shorter in our study (median, 27 months; IR, 14-55).…”

Section: Discussioncontrasting

confidence: 55%

“…(19) The results of those studies were not replicated in our study, possibly due to differences in duration of hemodialysis. In comparison with the study mentioned above, (19) for example, the duration of hemodialysis (85 ± 41 months) was considerably shorter in our study (median, 27 months; IR, 14-55). Since we found duration of hemodialysis to present a significant negative correlation with MIP and MEP (Figure 2), the patients in the study conducted by Karacan et al (4) would have actually been expected to exhibit a more pronounced decrease in MIP.…”

Section: Discussioncontrasting

confidence: 55%

Função pulmonar e força muscular respiratória em pacientes com doença renal crônica submetidos à hemodiálise

et al. 2008

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Objective: To evaluate pulmonary function and respiratory muscle strength in chronic renal failure patients, correlating these variables with hemodialysis-related weight fluctuation; to study the correlation between the duration of hemodialysis and potential respiratory alterations. Methods: Seventeen patients (median age, 47 years; interquartile range, 41-52 years), submitted to three weekly hemodialysis sessions for a median of 27 months (interquartile range, 14-55) were evaluated. Twelve of the patients were male. The patients underwent spirometry. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were measured prior to and after the first hemodialysis session of the week. Body weight was quantified prior to and after each of the three weekly sessions. Results: Before the first hemodialysis session of the week, 8 patients presented mild restrictive defect, which normalized after the session in 2 of those patients. After dialysis, there was a significant increase in forced vital capacity (p = 0.02) and a significant decrease in body weight (p = 0.0001). Weight fluctuation over 3 days without hemodialysis tended to correlate with the variation in forced vital capacity in the first weekly session (r = 0.47; p = 0.055). Duration of hemodialysis correlated with predialysis MIP (r = −0.3; p = 0.03) and MEP (r = −0.63; p = 0.006). Conclusions: More pronounced weight gain in the interdialytic period is associated with worsening of lung function, which is almost fully reversible by hemodialysis. In addition, longer duration of hemodialysis is associated with decreased respiratory muscle strength.Keywords: Spirometry; Respiratory muscles/physiopathology; Kidney failure, chronic; Renal dialysis. ResumoObjetivo: Avaliar a função pulmonar e a força muscular respiratória de pacientes com doença renal crônica e correlacioná-las com a variação de peso ligada à realização de hemodiálise; estudar a correlação entre o tempo de hemodiálise e possíveis alterações respiratórias. Métodos: Foram avaliados 17 pacientes (mediana de idade, 47 anos; intervalo interquartílico, 41-52 anos) submetidos a três sessões semanais de hemodiálise (mediana de tempo, 27 meses; intervalo interquartílico, 14-55). Doze eram do sexo masculino. Realizaram espirometria e mensuração das pressões máximas inspiratória (PImáx) e expiratória (PEmáx) antes e após a primeira sessão semanal de hemodiálise. O peso corporal foi quantificado antes e após as três sessões semanais. Resultados: Oito pacientes apresentaram distúrbio restritivo leve antes da primeira sessão de hemodiálise. Desses, 2 normalizaram após a sessão. Houve aumento da capacidade vital forçada (p = 0,02) e diminuição de peso (p = 0,0001) ao final da primeira sessão semanal. A variação de peso durante três dias sem hemodiálise tendeu a se correlacionar com a variação da capacidade vital forçada na primeira sessão (r = 0,47; p = 0,055). O tempo de hemodiálise correlacionou-se com os valores da porcentagem do predito da PImáx (r = −0,53; p = 0,03) e com a PEmáx (r = −...

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“…These findings supported the involvement of small airways detected by spirometry. Various studies reported similar results (7,(52)(53)(54). Small airway disease may be attributed to the following conditions: chronic and often subclinical pulmonary edema, decreased serum albumin with consequent water and protein imbalance in microcirculation, recurrent infections, interstitial fibrosis, and alveolitis (7,(52)(53)(54).…”

Section: Echocardiographic Datasupporting

confidence: 63%

Chest and Cardiac Findings on High-Resolution Computed Tomography in Children on Regular Hemodialysis with Abnormal Spirometry

Sobh¹,

Hamdy²,

Abdel-Salam³

et al. 2017

Eurasian J Pulmonol

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Pulmonary Function in Uremic Patients on Long‐term Hemodialysis

Cited by 19 publications

References 14 publications

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Função pulmonar e força muscular respiratória em pacientes com doença renal crônica submetidos à hemodiálise

Chest and Cardiac Findings on High-Resolution Computed Tomography in Children on Regular Hemodialysis with Abnormal Spirometry

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