Pulmonary Function in Inflammatory Bowel Disease

Johnson, N M; Mee, A S; Jewell, D P; Sd, Clarke

doi:10.1159/000198228

Cited by 28 publications

(19 citation statements)

References 4 publications

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“…JOHNSON et al [13] and HEATHLEY et al [11] failed to find a significant correlation between elevated CIC levels and pulmonary abnormalities. The role of circulating intestinal endotoxins [24] and/or excessive discharge of protease from inflammatory areas has also been described.…”

Section: Discussionmentioning

confidence: 98%

“…Some authors found no difference in pulmonary function data in patients with inflammatory bowel disease and control groups [13,14]. HEATLEY et al [11] found abnormal lung function in about 50% of 102 patients with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, in patients free of clinical pulmonary manifestations and abnormalities of pulmonary function tests, abnormal chest radiographs or bronchoalveolar lavages have been reported [8][9][10][11][12]. These observations, however, have not been confirmed by other investigators [13,14]. These discrepancies may be due to the fact that the above studies have included adult patients suffering from acute ulcerative colitis (UC) and Crohn's disease (CD), which are clinically and histologically distinct.…”

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confidence: 99%

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Latent pulmonary function abnormalities in children with Crohn's disease

Munck

Murciano²,

Parienté³

et al. 1995

Eur Respir J

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Recently, latent pulmonary involvement has been described in adult patients with inflammatory bowel disease. It is unknown, however, whether this also occurs in children, and whether the pulmonary abnormalities differ between the acute phase and remission. The incidence of pulmonary abnormalities has been investigated in 26 children with acute or quiescent Crohn's disease in terms of the following parameters: clinical pulmonary symptoms, chest roentgenograms and pulmonary function tests, including lung transfer factor for carbon monoxide (TLCO). One child had a severe digital clubbing. Chest radiographs were normal in all subjects. No significant differences were found between acute and quiescent phase for pulmonary volumes and expiratory flows, but TLCO (% predicted) was significantly decreased during the active phase of the disease as compared to remission (53 +/- 15 vs 81 +/- 19% predicted). These data suggest that latent pulmonary involvement is also present in a paediatric population with active Crohn's disease, despite a short disease history and absence of smoking. Although the nature of this abnormality remains unclear, this extradigestive epiphenomenon should be taken into account with respect to the aetiopathogenesis of Crohn's disease.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Latent pulmonary function abnormalities in children with Crohn's disease

Munck

Murciano²,

Parienté³

et al. 1995

Eur Respir J

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“…Since its first report, abnormal pulmonary function tests (PFTs) have been reported in 17–55% patients with UC,2, 3, 4, 5, 6 including a decrease in gas transfer factor (diffusion lung capacity for carbon monoxide [DLCO]),7, 8 elevated functional residual capacity (FRC),9 decrease in maximal mid‐expiratory flow rate (MEFR),10 or an increased frequency of bronchial hyperresponsiveness11; however, in some studies, no abnormalities in PFT were found 10, 12. Various respiratory abnormalities reported in patients with UC include obstructive and interstitial lung disease,13 small and large airway disorders,14, 15 increase in bronchial sensitivity,11 bronchitis, bronchiectasis,16, 17 and bronchiolitis oblitrans 18.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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Background and AimUlcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study.MethodsEighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer.ResultsSubjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control (P < 0.005). Of the 24 patients with abnormal PFT, small airway, restrictive, and obstructive defects were detected in 12 (50%), 11 (45.8%), and 1 (4.2%) patients, respectively. Patients with abnormal PFT more often had active disease (15/24, 62.5% vs 23/63, 36.5%; P = 0.03). No relation of PFT abnormalities was found with age, sex, duration of disease, body mass index, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat UC.ConclusionUC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.

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“…Respiratory symptom prevalence ranges from 25.6% in a recent study of 30 UC and 9 CD patients to 50% in an older study of 11 Decreased forced expiratory volume in the 1 st second (FEV1), decreased FEV1/forced vital capacity (FVC) ratio, increased residual volume (RV)/total lung capacity (TLC) ratio, low forced expiratory flow (FEF25-75) and, more importantly, decreased DLCO are the parameters noted to be abnormal in IBD patients in the existing literature. While FEV1 and FEV1/FVC ratio have been found to be normal in certain older studies, other studies and recent data suggest mild functional compromise [33,34] . Results should be interpreted with caution since different criteria have been used to define abnormal and certain studies included smoking patients or an inappropriate control population.…”

Section: Symptoms -Clinical Examinationmentioning

confidence: 89%

Patterns of airway involvement in inflammatory bowel diseases

Papanikolaou

Kagouridis

Papiris

2014

WJGP

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Extraintestinal manifestations occur commonly in inflammatory bowel diseases (IBD). Pulmonary manifestations (PM) of IBD may be divided in airway disorders, interstitial lung disorders, serositis, pulmonary vasculitis, necrobiotic nodules, drug-induced lung disease, thromboembolic lung disease and enteropulmonary fistulas. Pulmonary involvement may often be asymptomatic and detected solely on the basis of abnormal screening tests. The common embryonic origin of the intestine and the lungs from the primitive foregut, the co-existence of mucosa associated lymphoid tissue in both organs, autoimmunity, smoking and bacterial translocation from the colon to the lungs may all be involved in the pathogenesis of PM in IBD. PM are mainly detected by pulmonary function tests and highresolution computed tomography. This review will focus on the involvement of the airways in the context of IBD, especially stenoses of the large airways, tracheobronchitis, bronchiectasis, bronchitis, mucoid impaction, bronchial granulomas, bronchiolitis, bronchiolitis obliterans syndrome and the co-existence of IBD with asthma, chronic obstructive pulmonary disease, sarcoidosis and a1-antitrypsin deficiency.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key words: Inflammatory bowel diseases; Airways; BronchiolitisCore tip: The lung is commonly involved in inflammatory bowel diseases; however, airway involvement is often overlooked. This review will help gastroenterologists recognize the involvement of the airways in the context of inflammatory bowel diseases (IBD), especially stenoses of the large airways, tracheobronchitis, bronchiectasis, bronchitis, mucoid impaction, bronchial granulomas, bronchiolitis, bronchiolitis obliterans syndrome and the co-existence of IBD with asthma, chronic obstructive pulmonary disease, sarcoidosis and a1-antitrypsin deficiency, and appropriately manage their patients.Papanikolaou I, Kagouridis K, Papiris SA. Patterns of airway involvement in inflammatory bowel diseases. World J Gastrointest Pathophysiol

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Pulmonary Function in Inflammatory Bowel Disease

Abstract: Pulmonary function has been assessed in patients with ulcerative colitis and Crohn’s disease and compared with a healthy population. No statistically significant differences were found in the measurements observed within the three groups.

Cited by 28 publications

References 4 publications

Latent pulmonary function abnormalities in children with Crohn's disease

Latent pulmonary function abnormalities in children with Crohn's disease

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

Patterns of airway involvement in inflammatory bowel diseases

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