Pulmonary Embolism

Morrell, M. Tessa; Truelove, S. C.; Barr, Andrew

doi:10.1136/bmj.2.5361.830

Cited by 98 publications

(31 citation statements)

References 16 publications

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“…This article noted a 30% mortality rate for untreated pulmonary embolism based on a compilation of data from Barritt and Jordan's 28 study, as well as 4 other studies from 1939 to 1961. [34][35][36][37] One of these investigations 34 did not actually assess mortality in untreated patients but did note an 18% to 25% mortality rate from recurrent pulmonary embolism in untreated patients, citing Barritt and Jordan's 28 work, as well as an older study. 38 The other 3 investigations have similar pitfalls to Barritt and Jordan's 28 study: clinical diagnosis of pulmonary embolism in a group composed largely of sick or postoperative inpatients.…”

Section: Introductionmentioning

confidence: 99%

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The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

Calder

Herbert

Henderson

2005

Annals of Emergency Medicine

144

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, all were retrospective analyses. [35][36][37] These articles also have methodology problems that have been described elsewhere, 39 problems that would likely preclude their publication in current peer-reviewed journals.…”

Section: Introductionmentioning

confidence: 99%

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

Calder

Herbert

Henderson

2005

Annals of Emergency Medicine

144

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“…While conventional planar scintigraphy may not give sufficient anatomical detail, SPECT allows true three dimensional projection of the lungs (Logus et al, 1984;Perring et al, 1994). These properties have made SPECT an ideal means of studying and/or diagnosing at least two areas of clinical studies-pulmonary embolism (PE) (Morell, 1963;Palmer et al, 2001;Bajc et al, 2002Bajc et al, , 2004 and pulmonary aerosol deposition (Fleming et al, 1995(Fleming et al, , 1996Fleming and Conway, 2001).…”

Section: Introductionmentioning

confidence: 96%

A new automated delineation method for SPECT lung scans using adaptive dual‐exponential thresholding

Wang

Yan

2007

Int J Imaging Syst Tech

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An accurate method for delineating lung contours in single photon emission computed tomography (SPECT) is critical to respiratory studies such as pulmonary embolism (PE) and respiratory aerosol deposition. Current delineation methods are not adaptive in nature and may require a priori information on lung volumes. We have developed a dual-exponential thresholding method that solely requires SPECT scans, and is fast, accurate, and adaptive in nature. A dataset consisted of 90 patients was studied retrospectively. While most were suspected of PE, other pulmonary disorders were also present. SPECT ventilation scans were obtained after inhalation of *40 MBq of 99mTc-Technegas. Examination of the corresponding natural logarithmically transformed histograms revealed dual exponential functions like pattern. Adaptive thresholds were found as the intercept between the two exponential functions. 350 Monte Carlo simulations representative of normally-ventilated scans with varying counts were used to quantitatively measure and evaluate the method. Our method correctly delineated lung volumes to above 97% agreement for 310 of the 350 Monte Carlo simulations with maximum count values greater than or equal to 31. The 40 low-count simulations were included purely as extreme cases. For real patient scenario, an experienced physician was called upon to visually delineate a sample of 50 actual patient scans, and these delineated lung volumes were used as gold standard and compared with those delineated using our method. Our results had an average of 96% agreement.

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“…Frequencies of PE up to 11 per cent have been reported when based on physical examination alone (Hurson et al 1979), and up to about 20 per cent when using pulmonary scintigraphy (Nillius et al 1978, Fredin & Arborelius 1982. The mortality of untreated PE varies between 30 per cent and 50 per cent (Morrell et al 1963, Pollak et al 1973. Death from PE may occur in spite of heparin treatment (Fredin & Nillius 1982).…”

mentioning

confidence: 99%

Screening and Treatment of Pulmonary Embolism After Total Hip Replacement

Fredin

1983

Acta Orthopaedica Scandinavica

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Pulmonary Embolism

Cited by 98 publications

References 16 publications

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

A new automated delineation method for SPECT lung scans using adaptive dual‐exponential thresholding

Screening and Treatment of Pulmonary Embolism After Total Hip Replacement

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