Pulmonary Capillary Hemorrhage Induced by Acoustic Radiation Force Impulse Shear Wave Elastography in Ventilated Rats

Miller, Douglas L.; Dong, Zhihong; Dou, Chunyan; Patterson, Brandon; Raghavendran, Krishnan

doi:10.1002/jum.14950

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…The safety issue of SWE has been raised since acoustically induced techniques require push pulses to displace the local tissues [29][30][31]. In this study, no haemoptysis or pneumothorax was observed among the 85 patients undertaking 2D-SWE measurements without biopsy.…”

Section: Discussionmentioning

confidence: 66%

Application of transthoracic shear-wave ultrasound elastography in lung lesions

Kuo

Chen

et al. 2020

Eur Respir J

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IntroductionThe tissue stiffness information may help in the diagnosis of lung lesions. This study aimed to investigate and validate the application of transthoracic two-dimensional shear-wave ultrasound elastography in differentiating malignant from benign subpleural lung lesions.MethodsThis study involved one retrospective observational derivation cohort from January 2016 to December 2017 and one prospective observational validation cohort from December 2017 to December 2019. The inclusion criterion was radiographic evidence of pulmonary lesions. The patients were categorised into the air-bronchogram and hypoechoic groups based on the B-mode grayscale images. The elasticity of subpleural lung lesions with acceptable shear-wave propagation was measured. Diagnoses were made on the basis of pathology, microbiological studies, or following up the clinical course for at least 6 months.ResultsA total of 354 patients were included. Among the 121 patients in the derivation cohort, a receiver operating characteristic curve was constructed and the cut-off point to differentiate benign from malignant lesions was 65 kPa with Youden index 0.60 and accuracy 84.3%. Among the 233 patients in the validation cohort, the diagnostic performance was maintained with Youden index 0.65 and accuracy 86.7%. Upon applying the cut-off point to the air-bronchogram group, Youden index was 0.70 and accuracy 85.0%.ConclusionsThis study validated the application of transthoracic shear-wave ultrasound elastography for assessing lung malignancy. A cut-off point of 65 kPa is suggested for predicting lung malignancy. Furthermore, for pulmonary air-bronchogram lesions with high elasticity, tissue proofing should be considered because of the high possibility of malignancy.

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Section: Discussionmentioning

confidence: 66%

Application of transthoracic shear-wave ultrasound elastography in lung lesions

Kuo

Chen

et al. 2020

Eur Respir J

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“…The intensity was significantly higher in the model with the contact point than in the model with the contact plane. 24 Regarding the application of conventional SWE to lung ultrasound, bleeding has been reported in animal studies 25,26 and its use for lung ultrasound is not recommended. Furthermore, in emergency medicine, the use of a small portable device is desired, and it is difficult to mount general SWE, which requires high-intensity ultrasonic waves to generate shear waves, on a small portable device.…”

Section: Discussionmentioning

confidence: 99%

B-line Elastography Measurement of Lung Parenchymal Elasticity

et al. 2023

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This paper proposes a method to determine the elasticity of the lung parenchyma from the B-line Doppler signal observed using continuous shear wave elastography, which uses a small vibrator placed on the tissue surface to propagate continuous shear waves with a vibration frequency of approximately 100 Hz. Since the B-line is generated by multiple reflections in fluid-storing alveoli near the lung surface, the ultrasonic multiple-reflection signal from the B-line is affected by the Doppler shift due to shear waves propagating in the lung parenchyma. When multiple B-lines are observed, the propagation velocity can be estimated by measuring the difference in propagation time between the B-lines. Therefore, continuous shear wave elastography can be used to determine the elasticity of the lung parenchyma by measuring the phase difference of shear wave between the B-lines. In this study, three elastic sponges (soft, medium, and hard) with embedded glass beads were used to simulate fluid-storing alveoli. Shear wave velocity measured using the proposed method was compared with that calculated using Young’s modulus obtained from compression measurement. Using the proposed method, the measured shear wave velocities (mean ± S.D.) were 3.78 ± 0.23, 4.24 ± 0.12, and 5.06 ± 0.05 m/s for soft, medium, and hard sponges, respectively, which deviated by a maximum of 5.37% from the values calculated using the measured Young’s moduli. The shear wave velocities of the sponge phantom were in a velocity range similar to the mean shear wave velocities of healthy and diseased lungs reported by magnetic resonance elastography (3.25 and 4.54 m/s, respectively). B-line elastography may enable emergency diagnoses of acute lung disease using portable ultrasonic echo devices.

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“…The only weak point that ultrasonic pulse testing technology depicts is the requirement of regular surfaces to enable the accurate measurement of the pulse velocities. Dynamic elastic modulus has been assessed by ultrasonic pulse testing for thermoplastic polymers [ 100 ], photo-clickable poly(ethylene glycol) hydrogels [ 101 ], composite blends [ 102 ], syntactic foams reinforced with hybrid fibers [ 103 ], liquid crystals [ 104 ], biological tissues [ 105 ] such as cortical bone [ 106 ] or pulmonary capillary tissues [ 107 ].…”

Section: Non-nanotechnology Techniques To Determine Mechanical Proper...mentioning

confidence: 99%

Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review

Magazzù

Marcuello

2023

Nanomaterials

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Soft matter exhibits a multitude of intrinsic physico-chemical attributes. Their mechanical properties are crucial characteristics to define their performance. In this context, the rigidity of these systems under exerted load forces is covered by the field of biomechanics. Moreover, cellular transduction processes which are involved in health and disease conditions are significantly affected by exogenous biomechanical actions. In this framework, atomic force microscopy (AFM) and optical tweezers (OT) can play an important role to determine the biomechanical parameters of the investigated systems at the single-molecule level. This review aims to fully comprehend the interplay between mechanical forces and soft matter systems. In particular, we outline the capabilities of AFM and OT compared to other classical bulk techniques to determine nanomechanical parameters such as Young’s modulus. We also provide some recent examples of nanomechanical measurements performed using AFM and OT in hydrogels, biopolymers and cellular systems, among others. We expect the present manuscript will aid potential readers and stakeholders to fully understand the potential applications of AFM and OT to soft matter systems.

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Pulmonary Capillary Hemorrhage Induced by Acoustic Radiation Force Impulse Shear Wave Elastography in Ventilated Rats

Cited by 10 publications

References 38 publications

Application of transthoracic shear-wave ultrasound elastography in lung lesions

Application of transthoracic shear-wave ultrasound elastography in lung lesions

B-line Elastography Measurement of Lung Parenchymal Elasticity

Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review

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