Pulmonary Abnormalities and Carotid Atherosclerosis in Ex-Smokers without Airflow Limitation

Pike, Damien; Kirby, Miranda; Lindenmaier, Tamas J; Sheikh, Khadija; Neron, Casey; Hackam, Daniel G.; Spence, J. David; Fenster, Aaron; Paterson, Nigel A. M.; Sin, Don D.; McCormack, David G.; Párraga, Grace

doi:10.3109/15412555.2014.908833

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…Most of earlier studies showed lower FEV 1 was associated with thicker IMT 3,5,8,15,18 and the presence of subclinical atherosclerosis, 3,7,10,15 However, a small study by Pike et al of 61 subjects without airflow limitation found that FEV 1 was not associated with IMT . 17 Similarly, most of the previous studies reported significant association of lower FVC observed to predicted ratio and FEV 1 /FVC ratio with carotid IMT. 18,19 Whether the association varied by smoking status was unclear.…”

Section: Discussionmentioning

confidence: 74%

“…[5][6][7][8][9][10][11] As smoking causes both chronic obstructive pulmonary disease (COPD) 12 and atherosclerosis, 13,14 some studies showed that the association between pulmonary function and atherosclerosis varied by smoking status. 5,[15][16][17] For example, the Atherosclerosis Risk in Communities (ARIC) Study showed that poor pulmonary function was significantly associated with atherosclerosis in smokers but not in never smokers. 5 Other studies, such as the Etude sur le Vieillissement Artériel study 6…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

Pan

Cai

et al. 2015

Atherosclerosis

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

Pan

Cai

et al. 2015

Atherosclerosis

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“…A few previous studies reported that decreased pulmonary function was related to CV risk factors in non-COPD patients but had some limitations [31, 32]. …”

Section: Discussionmentioning

confidence: 99%

“…In another small study of 27 asymptomatic ex-smokers, there was no association between FEV1 and thickened carotid IMT, but worse ventilation defect percent (VDP) measured by 3 He magnetic resonance imaging (MRI) was related to carotid atherosclerosis measurements including IMT, vessel wall volume, and total plaque volume [32]. …”

Section: Discussionmentioning

confidence: 99%

Relationship between FEV1 and Cardiovascular Risk Factors in General Population without Airflow Limitation

Lee

Kang

Jeong

et al. 2016

Canadian Respiratory Journal

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Purpose. We aimed to determine the value of lung function measurement for predicting cardiovascular (CV) disease by evaluating the association between FEV1 (%) and CV risk factors in general population. Materials and Methods. This was a cross-sectional, retrospective study of subjects above 18 years of age who underwent health examinations. The relationship between FEV1 (%) and presence of carotid plaque and thickened carotid IMT (≥0.8 mm) was analyzed by multiple logistic regression, and the relationship between FEV1 (%) and PWV (%), and serum uric acid was analyzed by multiple linear regression. Various factors were adjusted by using Model 1 and Model 2. Results. 1,003 subjects were enrolled in this study and 96.7% (n = 970) of the subjects were men. In both models, the odds ratio of the presence of carotid plaque and thickened carotid IMT had no consistent trend and statistical significance. In the analysis of the PWV (%) and uric acid, there was no significant relationship with FEV1 (%) in both models. Conclusion. FEV1 had no significant relationship with CV risk factors. The result suggests that FEV1 may have no association with CV risk factors or may be insensitive to detecting the association in general population without airflow limitation.

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Three-dimensional ultrasound measurements of carotid vessel wall and plaque thickness and their relationship with pulmonary abnormalities in ex-smokers without airflow limitation

Cheng

Pike

Chow

et al. 2016

Int J Cardiovasc Imaging

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The relationship between carotid disease and modestly abnormal airflow in ex-smokers without chronic obstructive pulmonary disease (COPD) is not well-understood. We generated 3D ultrasound measurements of carotid vessel-wall-plus-plaque thickness (VWT) and vessel wall volume (VWV) to quantify and evaluate such carotid ultrasound measurements in ex- and never-smokers without airflow limitation. These patients did not fulfill the diagnostic criteria for COPD. We also investigated the relationship of carotid atherosclerosis with pulmonary phenotypes of COPD. We evaluated 61 subjects without a clinical diagnosis of pulmonary or vascular diseases including 34 never-smokers (72 ± 6 year) and 27 ex-smokers (73 ± 9 year). We measured mean VWT ([Formula: see text]) and mean VWT specific to carotid regions-of-interest ([Formula: see text]) and evaluated potential differences between ex- and never-smokers. Carotid ultrasound and pulmonary disease measurement relationships were also evaluated using correlation coefficients (r) and multivariate regression analyses. Ex-smokers had a significantly greater [Formula: see text] (p = 0.003) and [Formula: see text] (p < 0.00001) than never-smokers, whereas a significant difference between the two groups was not detected by VWV (p = 1.0). There were significant correlations between the ventilation defect percent (VDP) measured by MRI with [Formula: see text] (r = 0.42, p = 0.001) and [Formula: see text] (r = 0.56, p = 0.00001). Multivariate regression models showed that VDP significantly predicted [Formula: see text] (β = 0.38, p = 0.004) and [Formula: see text] (β = 0.50, p = 0.00001). VWT-based measurements detected differences in vessel-wall-plus-plaque burden in ex- and never-smokers, which were not revealed using VWV. There were significant correlations between cardiovascular and pulmonary disease biomarkers in these ex-smokers who did not have a clinical diagnosis of pulmonary or carotid disease.

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Pulmonary Abnormalities and Carotid Atherosclerosis in Ex-Smokers without Airflow Limitation

Cited by 5 publications

References 62 publications

The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

Relationship between FEV1 and Cardiovascular Risk Factors in General Population without Airflow Limitation

Three-dimensional ultrasound measurements of carotid vessel wall and plaque thickness and their relationship with pulmonary abnormalities in ex-smokers without airflow limitation

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