The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

Pan, Jing; Xu, Lin; Cai, Shao xi; Jiang, Chao Qiang; Cheng, Kar Keung; Zhao, Hai Jin; Zhang, Wei Sen; Jin, Ya Li; Lin, Jie; Thomas, G. Neil; Lam, Tai Hing

doi:10.1016/j.atherosclerosis.2015.09.036

Cited by 16 publications

(21 citation statements)

References 31 publications

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“…A study by Chae et al found that the amount of vascular calcification was associated with the extent of emphysema on computed tomography and airflow limitation (22). This is in contrast with a recent study from China on elderly smokers with airflow limitation that found no evidence that the association of pulmonary function with CIMT varied by smoking status (23). …”

Section: Discussioncontrasting

confidence: 99%

Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study

et al. 2016

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Background and aims Airflow limitation, i.e. reduced forced expiratory volume in one-second (FEV1) is associated with increased prevalence of atherosclerosis, however, causal mechanisms remain elusive. The objective of the study was to determine if the association between airflow obstruction and markers of atherosclerosis were mediated by systemic inflammation. Methods 1154 subjects from the longitudinal AGES Reykjavik study were included. Population characteristics, systemic inflammation markers from blood (white blood cell counts (WBC) and level of C-reactive protein (CRP)) were compared between patients with and without airflow limitation defined by reduced FEV1 on spirometry. Atherosclerosis burden was quantified by measurements of coronary artery calcium, aortic arch and distal aortic calcification in addition to carotid intimal media thickness (CIMT). Results Subjects were split into four groups according to smoking status and if airflow limitation was present. There was a higher overall burden of atherosclerosis in ever-smokers compared to never-smokers, and in individuals with airflow obstruction compared to individuals without airflow obstruction. After adjusting for population characteristics, Framingham cardiovascular risk factors and markers of systemic inflammation (WBC and CRP), there was a significantly more aortic arch and distal aorta calcification and higher measurement of CIMT for individuals with airflow obstruction compared to individuals without airflow obstruction. After adjusting for population characteristics, Framingham cardiovascular risk factors and markers of systemic inflammation (WBC and CRP), there was a significantly more aortic arch and distal aorta calcification and higher measurement of CIMT for individuals with airflow obstruction compared to individuals without airflow obstruction. Conclusions Systemic inflammation (WBC and CRP) does not appear to mediate the association between airflow limitation and atherosclerosis. Only airflow limitation and not systemic inflammation (WBC and CRP) appears to be an independent predictor of atherosclerosis.

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Section: Discussioncontrasting

confidence: 99%

Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study

et al. 2016

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“…Observationally poorer intrauterine experiences, proxied by birth weight or premature birth, are adversely associated with many aspects of adult health, including poorer lung function [2][3][4][5][6] . Lung function contributes both directly to chronic diseases via lung diseases and indirectly as a cardiovascular-related risk factor 7,8 , with potentially a causal role of forced expiratory volume 9 .…”

mentioning

confidence: 99%

Birth weight and prematurity with lung function at ~17.5 years: “Children of 1997” birth cohort

Kwok

Yeung

et al. 2020

Sci Rep

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We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV 1), forced vital capacity (FVC), and forced expiratory flow at 25-75% of the pulmonary volume (FEF 25-75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV 1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF 25-75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV 1 /FVC and FEF 25-75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness. 75%)) in extreme preterm births while fewer studies have focused on lung function in late preterm births 6,19,22-26. Evidence from twin studies, which are less open to confounding by family socioeconomic position, is limited, but suggests lower birth weight is associated with poorer lung function, i.e. lower expiry in the first second

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“…In 9 studies [19,23,25,26,34,35,37,42,43], we found a significantly higher CIMT in 726 COPD patients than in 2130 controls (MD: 0.10 mm; 95% CI: 0.04, 0.16; p ¼ 0.0007, Fig. 1A), with high detected heterogeneity (I 2 ¼ 94%, p < 0.0001).…”

Section: Cimt and Carotid Plaquesmentioning

confidence: 76%

Subclinical atherosclerosis risk markers in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

Wang

Zhu

Cui

et al. 2017

Respiratory Medicine

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The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

Abstract: Independent of smoking status, poor pulmonary function was dose-dependently associated with carotid atherosclerosis in older Chinese. (281 words).

Cited by 16 publications

References 31 publications

Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study

Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study

Birth weight and prematurity with lung function at ~17.5 years: “Children of 1997” birth cohort

Subclinical atherosclerosis risk markers in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

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