Pullularia Corneal Ulcer

Jones, F. R.; Christensen, Gerald R.

doi:10.1001/archopht.1974.01010010543018

Cited by 14 publications

(13 citation statements)

References 6 publications

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“…A. pullulans had been reported to cause nosocomial infection, abscess in the spleen, invasive pulmonary infection, fungemia, peritonitis (among patients on peritoneal dialysis), pneumonia, meningitis, corneal ulcer, catheter-related septicemia, scleral infection, and asthma (Bolignano and Criseo 2003;Clark et al 1995;Hawkes et al 2005;Jones and Christensen 1974;Panda et al 2006;Huang et al 2008;Salkin et al 1986;Niedoszytko et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Emergence of Aureobasidium pullulans as human fungal pathogen and molecular assay for future medical diagnosis

et al. 2011

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Despite the great importance of Aureobasidium pullulans in biotechnology, the fungus had emerged as an opportunistic human pathogen, especially among immunocompromised patients. Clinical detection of this rare human fungal pathogen presently relies on morphology diagnosis which may be misleading. Thus, a sensitive and accurate quantitative molecular assay for A. pullulans remains lacking. In this study, we presented the microscopy observations of A. pullulans that reveals the phenotypic plasticity of the fungus. A. pullulans-specific primers and molecular beacon probes were designed based on the fungal 18S ribosomal RNA (rRNA) gene. Comparison of two probes with varied quencher chemistry, namely BHQ-1 and Tamra, revealed high amplification efficiency of 104% and 108%, respectively. The optimized quantitative real-time PCR (qPCR) assays could detect and quantify up to 1 pg concentration of A. pullulans DNA. Both assays displayed satisfactory performance parameters at fast thermal cycling mode. The molecular assay has great potential as a molecular diagnosis tool for early detection of fungal infection caused by A. pullulans, which merits future study in clinical diagnosis.

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Section: Introductionmentioning

confidence: 99%

Emergence of Aureobasidium pullulans as human fungal pathogen and molecular assay for future medical diagnosis

et al. 2011

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“…Aureobasidium pullulans described under phaeohyphomycoses is a dematiaceous fungus and its pathogenicity was questioned towards corneal disease 19 . So far only four cases have been reported in causing corneal infection in world literature 6–9 . The emergence of this less common but medically important fungal pathogens contributes to the rate of morbidity and mortality 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Further studies also revealed that these organisms do not respond to amphotericin and are more susceptible to fluconazole, itraconazole and flucytosine 31,32 . Although optimal antifungal therapy against A. pullulans is not defined because of very few clinical reports available, its susceptibility has been tested in the laboratory 6,33 . The reports highlighted its susceptibility to amphotericin, fluconazole, ketaconazole, itraconazole and flucytosine 6,31–34 .…”

Section: Discussionmentioning

confidence: 99%

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Aureobasidium pullulans keratitis

Panda¹,

Das²,

Deb

et al. 2006

Clinical Exper Ophthalmology

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“…Amphotericin-B alone or in combination with azoles has been tried with variable success. [3][4][5]8,9 Combination therapy is probably the treatment of choice. The duration of treatment is not certain, though most patients received antifungal treatment for 4-8 weeks.…”

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confidence: 99%