Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity

Li, Bo; Liu, Mingyan; Wang, Yu; Gong, Shiqiang; Yao, Weifan; Li, Wenshuai; Gao, Hua; Wei, Minjie

doi:10.1016/j.biopha.2020.110923

Cited by 60 publications

(51 citation statements)

References 36 publications

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“…Pueraria extract prevented ovariectomy-induced bone loss in rats [ 98 ]. Puerarin, that is, the main active ingredient of Pueraria extract, slows down the bone loss and reverses the ovariectomy-induced increase in bone turnover in rats [ 99 ]. It also alleviated osteopenia and prevented the deterioration of trabecular structure in mCT [ 99 ].…”

Section: Phytoestrogensmentioning

confidence: 99%

“…Puerarin, that is, the main active ingredient of Pueraria extract, slows down the bone loss and reverses the ovariectomy-induced increase in bone turnover in rats [ 99 ]. It also alleviated osteopenia and prevented the deterioration of trabecular structure in mCT [ 99 ]. Other authors reported that puerarin inhibited RANKL-dependent osteoclastogenesis [ 100 ], induced mineral nodulus formation in osteoblasts through the activation of PI3K/AKT signalling pathway [ 101 ] and promotes osteoblast differentiation [ 102 ].…”

Section: Phytoestrogensmentioning

confidence: 99%

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Botanicals in Postmenopausal Osteoporosis

2021

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Osteoporosis is a systemic bone disease characterized by reduced bone mass and the deterioration of bone microarchitecture leading to bone fragility and an increased risk of fractures. Conventional anti-osteoporotic pharmaceutics are effective in the treatment and prophylaxis of osteoporosis, however they are associated with various side effects that push many women into seeking botanicals as an alternative therapy. Traditional folk medicine is a rich source of bioactive compounds waiting for discovery and investigation that might be used in those patients, and therefore botanicals have recently received increasing attention. The aim of this review of literature is to present the comprehensive information about plant-derived compounds that might be used to maintain bone health in perimenopausal and postmenopausal females.

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Section: Phytoestrogensmentioning

confidence: 99%

Section: Phytoestrogensmentioning

confidence: 99%

Botanicals in Postmenopausal Osteoporosis

2021

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“…Estrogen replacement therapy is effective in increasing osteoblast activity but also increases the incidence of breast and uterine cancer [10,11]. Phytoestrogens have attracted attention due to the potential impacts on the prevention and treatment of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the patient's functional status and quality of life are reduced, with a high risk for short-term mortality, as well as large medical expenses [8,9]. Estrogen replacement therapy is effective in increasing osteoblast activity but also increases the incidence of breast and uterine cancer [10,11]. Phytoestrogens have attracted attention due to the potential impacts on the prevention and treatment of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling

Jin¹,

Liao²,

Da³

et al. 2021

Preprint

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Introduction Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG. Methods In vivo, 12-month-old male mice were utilized to evaluate the effect of osthole on bone mass. In vitro, bone marrow stem cells (BMSCs) were isolated and extracted from 3-month-old OPG-/- mice and the littermates of OPG+/+ mice. calvaria osteoblasts were extracted from 3-day-old C57BL/6J mice or 3-day-old OPG-/- mice and the littermates of OPG+/+ mice.Results Osthole significantly increased the gene and protein levels of OPG in primary BMSCs in a dose-dependent manner. The deletion of the OPG gene did not affect β-catenin expression. The deletion of the β-catenin gene inhibited OPG expression in BMSCs, indicating that osthole stimulates the expression of OPG via activation of β-catenin signaling.Conclusion Osthole attenuates osteoclast formation by stimulating the activation of β-catenin-OPG signaling and could be a potential drug for the senile osteoporosis.

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“…Estrogen replacement therapy are effective in increasing osteoblast activity, but resulted in the increased incidence of breast and uterine cancer [10][11] . Phytoestrogens have attracted attention to their potential impacts in the prevention and treatment for osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Osthole Inhibits Osteoclast Formation and Enhances Bone Mass of Bone Marrow Mesenchymal Stem cells by Activating β-catenin-OPG Signaling Pathway

Jin¹,

Liao²,

Da³

et al. 2020

Preprint

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Summary Osthole has potential therapeutic applications due to its antiosteoporotic. Our study suggested that osthole attenuates osteoclast formation by stimulating the activation of β-catenin-OPG signaling and could be a potential agent to inhibit bone resorption. Introduction Osthole has potential therapeutic applications due to its antiosteoporotic. we performed study to test if OPG is the target gene of osthole-attenuated osteoclastogenesis. Methods In vivo, using 12-month-old male mice to evaluate the effect of osthole on bone mass. In vitro, Bone marrow stem cells (BMSCs) were isolated, extracted from 3-month-old C57BL/6J mice, 3-month-old β-cateninfx/fx mice, or 3-month-old OPG−/− mice and its littermates of OPG+/+ mice. Results we found that osthole significantly increased the gene and protein levels of OPG expression in primary BMSCs dose-dependently. The deletion of the OPG gene did not affect β-catenin expression and the deletion of the β-catenin gene inhibited OPG expression in BMSCs, which indicated that osthole stimulated the expression of OPG through activation of β-catenin signaling. Conclusion Osthole attenuates osteoclast formation by stimulating the activation of β-catenin-OPG signaling and could be a potential agent to inhibit bone resorption.

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Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity

Cited by 60 publications

References 36 publications

Botanicals in Postmenopausal Osteoporosis

Botanicals in Postmenopausal Osteoporosis

Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling

Osthole Inhibits Osteoclast Formation and Enhances Bone Mass of Bone Marrow Mesenchymal Stem cells by Activating β-catenin-OPG Signaling Pathway

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