Botanicals in Postmenopausal Osteoporosis

Słupski, Wojciech; Jawień, Paulina; Nowak, Beata

doi:10.3390/nu13051609

Cited by 77 publications

(51 citation statements)

References 152 publications

(169 reference statements)

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“…Ipriflavone, a synthetic isoflavone, is a nutraceutical used as a complementary, prophylactic, or alternative therapy for primary and menopause-related osteoporosis [85,86]. IPRI was found to prevent bone loss and enhance intestinal calcium absorption [87] and BMD [88].…”

Section: Discussionmentioning

confidence: 99%

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

et al. 2022

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Oxidative stress associated with long-term glucocorticoids administration is a route through which secondary osteoporosis can be developed. The therapeutic potential of Phoenix dactilyfera L. pits is offered by their balanced, valuable and diverse phytochemical composition providing protective potential against oxidative reactions, making it a good candidate to treat glucocorticoid-induced osteoporosis (GIO). This study evaluates the possible anti-osteoporotic effect of date pit extract (DPE) against dexamethasone (DEXA)-induced osteoporosis. Male rats were allocated into three control groups, which received saline, low and high doses of DPE (150 and 300 mg/kg/day), respectively. Osteoporosis-induced groups that received DEXA (1 mg/kg/day) were divided into DEXA only, DPE (2 doses) + DEXA, and ipriflavone + DEXA. Femoral bone minerals density and bone mineral content, bone oxidative stress markers, Wnt signaling, osteoblast and osteoclast differentiation markers, and femur histopathology were evaluated. DPE defeated the oxidative stress, resulting in ameliorative changes in Wnt signaling. DPE significantly reduced the adipogenicity and abolished the osteoclastogenic markers (RANKL/OPG ratio, ACP, TRAP) while enhancing the osteogenic differentiation markers (Runx2, Osx, COL1A1, OCN). In Conclusion DPE restored the balanced proliferation and differentiation of osteoclasts and osteoblasts precursors. DPE can be considered a promising remedy for GIO, especially at a low dose that had more potency.

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Section: Discussionmentioning

confidence: 99%

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

et al. 2022

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“…Первинний розвивається як самостійна патологія, коли втрата кісткової тканини та зменшення її маси пов'язані з природними змінами (постменопаузальний, сенільний, ювенальний). Вторинний -виникає внаслідок ряду основних захворювань органів і систем (ревматичних, гормональних, аутоімунних патологій, хвороб органів кровотворення), ранньої оваріоектомії, довготривалої імобілізації за високоенергетичних переломів кісток, дії токсичних речовин або ж під впливом тривалого застосування лікарських препаратів, зокрема глюкокортикоїдів (Goldhahn et al, 2005;Smith et al, 2009;Oheim et al, 2012a;Oheim et al, 2012b;Bonucci & Ballanti, 2014;Słupski et al, 2021;Oheim et al, 2022).…”

Section: вступunclassified

X-ray macromorphological and biochemical assessment of consolidation of fractures of long tubular bones under conditions of osteoreplacement with calcium-phosphate ceramics doped with germanium for osteoporosis in rab-bits

et al. 2022

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Among several factors that can cause a violation of the course of reparative osteogenesis, previous diseases associated with a change in the structural and functional state of bone tissue and primarily osteoporosis are considered significant. Osteoporotic fractures are difficult to treat. Along with systemic therapy, locally applied bone substitute materials, particularly unalloyed and alloyed calcium phosphate ceramics with pronounced osteoconductive, osteoinductive, and osteointegration properties. The work aims to evaluate the effect of calcium-phosphate ceramics doped with germanium on post-traumatic bone regeneration in conditions of secondary osteoporosis in rabbits. Experimental osteoporosis in rabbits was induced by administration of 0.4 % dexamethasone solution (KRKA, Slovenia) for 21 days at a dose of 1.2 mg/kg of body weight. Experimental (n = 9) and control (n = 9) groups of animals were formed. Animals of the experimental group had defects replaced with granules of hydroxyapatite ceramics, synthesized based on hydroxyapatite and β-tricalcium phosphate, doped with germanium. In rabbits of the control group, bone defects healed under a blood clot. Blood samples to determine the level of total calcium (Ca) and inorganic phosphorus (P) were taken before surgery and on 7-,14th, 30th, and 60th day of the study. X-ray studies were performed on the RUM-20 X-ray machine on the 14th, 30th, and 60th day of reparative osteogenesis. Radiologically and macromorphologically, it was established that reparative osteogenesis in the experimental animals proceeds more dynamically compared to the control group and is characterized by a high density of bone tissue at the site of the defect already on the 14th day after the injury, a moderate periosteal and early appearance of the endosteal reaction. The content of total calcium in the animals of the experimental group on the 14th day after the injury was 1.3 times (P < 0.001) higher than that of the control and animals before the operation, and on the 30th day, it was 1.2 times (P < 0.001) in accordance. The concentration of inorganic phosphorus (P) on the 14th and 30th days of reparative osteogenesis in animals of the experimental group was 1.1 times (P < 0.05) lower than in control animals, and on the 60th day in 1.4 times (P < 0.01), respectively. Systemic osteoporosis in experimental animals causes a violation of reparative osteogenesis due to the prolongation of the inflammatory-resorptive stage and cartilaginous callus and complicated mineralization of bone regeneration. Calcium-phosphate ceramics is a promising material for replacing bone defects in animals with systemic secondary osteoporosis.

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“…The prevalence of osteoporosis in the United States proves that 30% of women with menopause condition suffer from bone loss or osteoporosis. Menopausal women are at particular risk because estrogen loss will lead to bone mass loss much greater than one would expect based on age alone [3,4].…”

Section: Introductionmentioning

confidence: 99%

Local Non Soy Isoflavone Attenuates Bone Loss In The Menopausal Women

Indrawan

Wiyasa

Hidayat

et al. 2022

a-jhr

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Background: Identification and isolation of local non-soy isoflavone based on cow pea (Vigna unguiculata) by The Indonesian Menopause Society (PERMI) in Malang District, Indonesia No published studies have directly examined the effect of that non-soy isoflavone on bone mineral density in menopausal women. Objective: To determine the effect of 24 weeks' consumption of non-soy isoflavone (67,5 mg) to reduce osteoporotic bone loss in menopausal women. Design and Methods: Menopausal subjects were randomly assigned, double-blind to treatment: non-soy isoflavone (n-30), or placebo (n-30). At baseline and posttreatment, bone mineral density (BMD) was measured by using quantitative ultrasonography. Collected data were analyzed by Analysis of Covariance (ANCOVA). Results: There were no differences in BMD changes between the treatment and placebo group for 24 weeks intervention. The mean of BMD changes in treatment group were 0,952 (p-value 0,006, SE-0,221) from baseline, and the placebo group had mean at -0,768 (p-value -0,006, SE-0,212). Despite this, coffee as the concomitant variable had a significant effect on BMD changes (p value=0,43) at 3rd-month evaluation, but not in 6 months. Participant compliance is good. Conclusion: Non-soy Isoflavone attenuates bone loss in menopausal women. Keywords: non-soy, phytoestrogen, osteoporosis, postmenopausal women

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Botanicals in Postmenopausal Osteoporosis

Cited by 77 publications

References 152 publications

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

X-ray macromorphological and biochemical assessment of consolidation of fractures of long tubular bones under conditions of osteoreplacement with calcium-phosphate ceramics doped with germanium for osteoporosis in rab-bits

Local Non Soy Isoflavone Attenuates Bone Loss In The Menopausal Women

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