Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1α, TIMP-3 and BCL-2 expressions

Waqas, Muhammad; Qamar, Hammad; Zhang, Jialü; Yao, Wangyuan; Li, Aoyun; Wang, Yaping; Iqbal, Mudassar; Mehmood, Khalid; Jiang, Xiong; Li, Jiakui

doi:10.1016/j.ecoenv.2019.110126

Cited by 28 publications

(14 citation statements)

References 59 publications

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“…Puerarin [7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one 8-(β- d -glucopyranoside)] is the main polyphenol isolated from the Chinese herb radix of Pueraria lobata (willd) ohwi, which has been widely used in the treatment of cardiovascular diseases, diabetes, periodontal disease, endometriosis, and cancer. , Polyphenols have an effect on the regulation of the mucus layer of the colon. Zhang et al showed that chlorogenic acid could attenuate the mucosal damage, such as sloughing of epithelial cells and downregulation of mucin.…”

Section: Introductionmentioning

confidence: 99%

“…Several reports indicate that short-chain fatty acids (SCFAs), particularly butyrate, can increase Muc2 gene expression in the rat colon through an inhibitory effect on histone-deacetylase. 18,19 Puerarin [7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4one 8-(β-D-glucopyranoside)] is the main polyphenol isolated from the Chinese herb radix of Pueraria lobata (willd) ohwi, which has been widely used in the treatment of cardiovascular diseases, 20 diabetes, 21 periodontal disease, 20 endometriosis, 22 and cancer. 23,24 Polyphenols have an effect on the regulation of the mucus layer of the colon.…”

Section: ■ Introductionmentioning

confidence: 99%

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Puerarin Rebuilding the Mucus Layer and Regulating Mucin-Utilizing Bacteria to Relieve Ulcerative Colitis

Ruan

et al. 2020

J. Agric. Food Chem.

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The colonic mucus barrier serves as a primary defense against enteric pathogens; destruction of this mucus layer has been observed in ulcerative colitis patients. This study aims to investigate the possibility of rebuilding the colon mucus layer through puerarin supplementation, which can stimulate mucin secretion and goblet cells differentiation. After puerarin supplementation, the thickness of colon mucus layer was increased and the permeability was reduced. The erosion of intestinal epithelium by bacteria was blocked, and the loss of epithelial integrity was alleviated. Puerarin also altered the composition of mucin-utilizing bacteria, which influenced the mucus permeability. Levels of short-chain fatty acids (SCFAs) were increased after puerarin supplementation, which as a direct source of energy for the proliferation of epithelia and goblet cells. This study demonstrated that enhancement of mucin secretion to relieve ulcerative colitis (UC) by puerarin supplementation is feasible, and the regulation of mucin-utilizing bacteria and the increased levels of SCFAs may be the main reasons.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Puerarin Rebuilding the Mucus Layer and Regulating Mucin-Utilizing Bacteria to Relieve Ulcerative Colitis

Ruan

et al. 2020

J. Agric. Food Chem.

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“…Puerarin prominently alleviated oxidative stress through TLR4/NLRP3 inflammasome activation [79], Nrf2 pathway [80,81], and antioxidant enzymes [80] by significantly downregulating HIF-1α and upregulating TIMP-3 and BCL-2 [82]. Moreover, puerarin may inhibit MAPK and active STAT3 to enhance the antioxidant capacity [83].…”

Section: Tcm-based Bioactive Compounds Andmentioning

confidence: 99%

Effects of Traditional Chinese Medication‐Based Bioactive Compounds on Cellular and Molecular Mechanisms of Oxidative Stress

Liang

Zhu

et al. 2021

Oxidative Medicine and Cellular Longevity

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The oxidative stress reaction is the imbalance between oxidation and antioxidation in the body, resulting in excessive production of oxygen free radicals in the body that cannot be removed, leading to excessive oxidation of the body, and causing damage to cells and tissues. A large number of studies have shown that oxidative stress is involved in the pathological process of many diseases, so inhibiting oxidative stress, that is, antioxidation, is of great significance for the treatment of diseases. Studies have shown that many traditional Chinese medications contain antioxidant active bioactive compounds, but the mechanisms of those compounds are different and complicated. Therefore, by summarizing the literature on antioxidant activity of traditional Chinese medication-based bioactive compounds in recent years, our review systematically elaborates the main antioxidant bioactive compounds contained in traditional Chinese medication and their mechanisms, so as to provide references for the subsequent research.

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“…Additionally, earlier research has shown that TH (thiram) may cause TD in chickens at the dose rate of 50 mg/kg [ 5 , 21 ]. Moreover, it has been frequently mobilized to imitate TD in numerous research trials [ 22 , 23 , 24 , 25 ]. Our prior studies indicate that thiram induces apoptosis in chondrocytes raising the number of apoptotic chondrocytes inside the osteogenesis area [ 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Regulatory Role of Apoptotic and Inflammasome Related Proteins and Their Possible Functional Aspect in Thiram Associated Tibial Dyschondroplasia of Poultry

Kulyar

Yao

et al. 2022

Animals

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Tibial dyschondroplasia debilities apoptotic and inflammasomal conditions that can further destroy chondrocytes. Inflammasomes are specialized protein complexes that process pro-inflammatory cytokines, e.g., interleukin-1β (IL-1β) and IL-18. Moreover, there is mounting evidence that many of the signaling molecules that govern programmed cell death also affect inflammasome activation in a cell-intrinsic way. During the last decade, apoptotic functions have been described for signaling molecules involving inflammatory responses and cell death pathways. Considering these exceptional developments in the knowledge of processes, this review gives a glimpse of the significance of these two pathways and their connected proteins in tibial dyschondroplasia. The current review deeply elaborates on the elevated level of signaling mediators of mitochondrial-mediated apoptosis and the inflammasome. Although investigating these pathways’ mechanisms has made significant progress, this review identifies areas where more study is especially required. It might lead to developing innovative therapeutics for tibial dyschondroplasia and other associated bone disorders, e.g., osteoporosis and osteoarthritis, where apoptosis and inflammasome are the significant pathways.

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Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1α, TIMP-3 and BCL-2 expressions

Cited by 28 publications

References 59 publications

Puerarin Rebuilding the Mucus Layer and Regulating Mucin-Utilizing Bacteria to Relieve Ulcerative Colitis

Puerarin Rebuilding the Mucus Layer and Regulating Mucin-Utilizing Bacteria to Relieve Ulcerative Colitis

Effects of Traditional Chinese Medication‐Based Bioactive Compounds on Cellular and Molecular Mechanisms of Oxidative Stress

Regulatory Role of Apoptotic and Inflammasome Related Proteins and Their Possible Functional Aspect in Thiram Associated Tibial Dyschondroplasia of Poultry

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