Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control

Chang, Xing; Zhang, Tian; Dong, Liang; Qing, Meng; Yan, Peizheng; Luo, Dan; Wang, Xue; Zhou, Xiuteng

doi:10.1155/2021/6659240

Cited by 32 publications

(26 citation statements)

References 65 publications

(69 reference statements)

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“…Together, these studies suggested that inflammation and ROS-mediated oxidative stress could be one of the important reasons for ventricular remodeling in the later stages of CHD. Furthermore, Zhou et al (78) have demonstrated that LPS-induced inflammatory response and oxidative stress can injure HUVECs, leading to a decrease in the expression of SIRT-1 in endothelial cells and the dysfunction of mitochondrial energy metabolism and activation of the mitochondrial apoptotic pathways.…”

Section: Inflammation-induced Oxidative Stress In the Progress Of Myo...mentioning

confidence: 99%

“…PUE can improve mitochondrial energy metabolism by improving mitophagy or inhibiting LPS-induced inflammatory response in HUVECs, thereby regulating the mechanism of oxidative stress reduction balance. Moreover, the protective effect of PUE on HUVECs is closely related to the SIRT-1 signaling pathway (78).…”

Section: Pharmacological Intervention In Human Clinical Trialsmentioning

confidence: 99%

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Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Liu

2022

Front. Cardiovasc. Med.

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Coronary heart disease (CHD) is one of the main causes of death worldwide. In the past few decades, several in-depth research on the pathological mechanisms and effective treatment methods for CHD have been conducted. At present, the intervention of a variety of therapeutic drugs and treatment technologies have greatly reduced the burden on global public health. However, severe arrhythmia and myocardial fibrosis accompanying CHD in the later stages need to be addressed urgently. Mitochondria are important structural components for energy production and the main sites for aerobic respiration in cells. Mitochondria are involved in arrhythmia, myocardial fibrosis, and acute CHD and play a crucial role in regulating myocardial ischemia/hypoxia. Mitochondrial dysfunction or mitophagy disorders (including receptor-dependent mitophagy and receptor-independent mitophagy) play an important role in the pathogenesis of CHD, especially mitophagy. Mitophagy acts as a “mediator” in the inflammatory damage of cardiomyocytes or vascular endothelial cells and can clear mitochondria or organelles damaged by inflammation under normal conditions. We reviewed experimental advances providing evidence that mitochondrial homeostasis or mitochondrial quality control are important in the pathological mechanism of CHD. Further, we reviewed and summarized relevant regulatory drugs that target mitochondrial function and quality control.

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Section: Inflammation-induced Oxidative Stress In the Progress Of Myo...mentioning

confidence: 99%

Section: Pharmacological Intervention In Human Clinical Trialsmentioning

confidence: 99%

Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Liu

2022

Front. Cardiovasc. Med.

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“…In recent years, the anti-inflammatory mechanisms of PR have been extensively studied, which involve the regulation of key signals such as TLR, Nrf2, HDAC and PPARα, [18][19][20][21][22] but also the improvement of organelle function. 23 However, no researches have yet explored whether PR reverses UUOmediated renal injury through anti-inflammatory and antifibrotic effects. In this context, we conceived the present study and hypothesised that PR could rescue renal function by regulating the NF-κB p65/STAT3 and TGF-β1/Smads pathways to inhibit renal fibrosis and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways

Wang¹,

Ge²,

Wang³

et al. 2021

DDDT

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Purpose Puerarin (PR), a Chinese medicine rich in natural components, has been reported to display anti-fibrotic, antioxidant, anti-inflammatory and immunomodulatory properties. However, the protective mechanism of PR against unilateral ureteral obstruction (UUO)-mediated renal injury is not fully clarified. Therefore, the aim of this study was to investigate the effects of PR on UUO mice and its possible mechanisms. Methods A total of 32 C57BL/6 mice were divided randomly into four groups (n=8): i) sham-operated group (Sham); ii) UUO group (UUO); iii) UUO + PR 50 mg/kg/day (UUO + PRL); and iv) UUO + PR 100 mg/kg/day (UUO + PRH). Continuous gavage administration for 14 days starting one week postoperatively, while the mice in Sham and UUO groups were given equal amounts of vehicle by the same means. All mice were then sacrificed and serum, 24-hour urine and tissue specimens were collected for renal function, histopathology, Western blot, immunohistochemistry. Results Renal function and histopathology revealed that PR improved UUO-mediated renal dysfunction and partially reversed tubular injury and tubulointerstitial fibrosis. Additionally, according to the results of Western blot and immunohistochemistry, PR inhibited the expression of inflammatory factors including IL-1β, IL-6, MCP-1 and ECM-related proteins including α-SMA, COL I and VIM. More importantly, the expression of fibrotic pathways TGF-β1, Smad3, p-Smad3 and inflammatory pathways NF-κB p65, NF-κB p-p65, STAT3, p-STAT3 were inhibited to various extents under the PR treatment, while Smad7 was upregulated. Conclusion These findings indicate that PR may inhibit the recruitment of inflammatory factors and extracellular matrix (ECM) deposition through the regulation of the NF-κB p65/STAT3 and TGFβ1/Smads pathways, which alleviates the UUO-induced inflammatory and fibrotic response, thereby reversing renal injury.

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“…Ohwi ( Zhang 2019 ). Puerarin exhibits a wide range of antioxidant activities in cardiovascular diseases, diabetes, obesity, osteoporosis, and other diseases ( Xu et al, 2021 ; Chang et al, 2021 ; Liu Y. et al, 2021 ; Xiao et al, 2020 ). In addition, puerarin has anti-inflammatory, anti-viral and other pharmacological activities ( Wang Z.-K. et al, 2020 ; Wang H. X. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Pang

et al. 2021

Front. Pharmacol.

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Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.

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Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control

Cited by 32 publications

References 65 publications

Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

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