Puerarin: A protective drug against ischemia-reperfusion injury

Abstract

Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dilating cerebral vessels and anti-free radical generation in cerebral ischemic tissues. With the deepening of experimental research and clinical research on puerarin, it has been found that puerarin has a protective effect on ischemia-reperfusion injury (IRI) of the heart, brain, spinal cord, lung, intestine and other organs. In summary, puerarin has a vast range of pharmacological effects and significant protective effects, and it also has obvious advantages in the clinical protection of patients with organ IRI. With the deepening of experimental pharmacological research and clinical research, it is expected to be an effective drug for IRI treatment. In this review, we summarize the current knowledge of the protective effect of puerarin on I/R organ injury and its possible underlying molecular mechanisms.

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

“…The spinal cord is more susceptible to damage caused by ischemia due to poor segmental blood supply [ 2 ]. Studies have shown that the main mechanisms in spinal cord injury following ischemia-reperfusion are the occurrence of oxidative stress, excessive inflammation, and as a result, apoptosis of cells in the ischemia site [ 1 ]. Finally, all these cases can disrupt the function of the spinal cord and cause serious disturbance in nerve exchanges in the damaged spinal cord segments as well as the lower segments of the injured area.…”

“…Paraplegia caused by spinal ischemia-reperfusion injury (IR) during abdominal aortic surgery is one of the most terrible and catastrophic events [ 1 ]. The incidence of this destructive complication in patients undergoing surgery is estimated at 30% [ 2 ].…”

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

“…Puerarin is one of the main monomers of total flavonoids from Pueraria lobata, and is an isoflavone phytoestrogen with important pharmacological effects, minimal adverse reactions, and high safety [ 205 , 206 ]. It has been reported that puerarin exhibits various pharmacological activities, including anti-inflammatory, anti-oxidative stress, anti-apoptosis, and anti-autophagy effects, which are beneficial for alleviating myocardial ischemia/reperfusion injury and treating ischemic cardiovascular diseases [ 207 , 208 ]. Jiang et al found that puerarin could inhibit sorafenib-induced myocardial ferroptosis, and has a good protective effect against the cardiotoxicity of sorafenib.…”

Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases

“…Puerarin is a flavonoid glycoside isolated from the root of the TCM Puerariae Lobatae Radix. Many researchers found that puerarin has a protective effect on ischemia-reperfusion injury of the heart, brain, spinal cord, lung, intestine, and other organs ( Gao et al, 2022 ). Studies have shown that puerarin may reduce the water channel function of AQP4 by regulating the cAMP/PKA/AQP4 pathway, thereby reducing subarachnoid hydrops ( Ying and Liu, 2020 ).…”