Pueraria lobata starch regulates gut microbiota and alleviates high-fat high-cholesterol diet induced non-alcoholic fatty liver disease in mice

Yang, Yifei; Li, Mingxing; Wang, Qin; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Shen, Jing; Luo, Haomin; Zhao, Qianyun; Zeng, Jiuping; Li, Wanping; Chen, Meijuan; Li, Xiaobing; Wang, Fang; Sun, Yuhong; Gu, Li; Xiao, Zhangang; Wu, Xu

doi:10.1016/j.foodres.2022.111401

Cited by 28 publications

(18 citation statements)

References 60 publications

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“…The higher alpha-diversity index, the higher the community diversity and the more uniform species dispersion. Beta-diversity is a comparative analysis of the microbial community composition of different samples to find differences between groups: 45,46 the shorter distance between the samples in pictures, the more comparable the community composition between the samples. Of the three indices of the alpha-diversity index, there was no significant difference among H, H.HTPM and H.HF (Fig.…”

Section: Resultsmentioning

confidence: 99%

Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens

et al. 2023

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“…Green Tea Polyphenols increased the levels of acetic acid and butyric acid, which may be related to the increase of Clostridium populati, Blautia luti, Akkermania muciniphila and Thiothrix unzii (125). The increase of SCFAs content in Pueraria lobata star may be due to the increase of the content of Lactobacillus, Bifidobacterium and Turicibacte (135). Using Inulin in NAFLD treatment, it was found that SCFAs were positively correlated with Bacteroidetes, Akkermania and Bifidobasterium, and negatively correlated with Proteobasteria, Blautia and Ileiberium (122).…”

Section: Scfasmentioning

confidence: 93%

Gut microbiota: The key to the treatment of metabolic syndrome in traditional Chinese medicine – a case study of diabetes and nonalcoholic fatty liver disease

Yang

Han

et al. 2022

Front. Immunol.

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Metabolic syndrome mainly includes obesity, type 2 diabetes (T2DM), alcoholic fatty liver (NAFLD) and cardiovascular diseases. According to the ancient experience philosophy of Yin-Yang, monarch-minister compatibility of traditional Chinese medicine, prescription is given to treat diseases, which has the advantages of small toxic and side effects and quick effect. However, due to the diversity of traditional Chinese medicine ingredients and doubts about the treatment theory of traditional Chinese medicine, the mechanism of traditional Chinese medicine is still in doubt. Gastrointestinal tract is an important part of human environment, and participates in the occurrence and development of diseases. In recent years, more and more TCM researches have made intestinal microbiome a new frontier for understanding and treating diseases. Clinically, nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM) often co-occur. Our aim is to explain the mechanism of interaction between gastrointestinal microbiome and traditional Chinese medicine (TCM) or traditional Chinese medicine formula to treat DM and NAFLD. Traditional Chinese medicine may treat these two diseases by influencing the composition of intestinal microorganisms, regulating the metabolism of intestinal microorganisms and transforming Chinese medicinal compounds.

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“…Analysis of the fecal microbial community was performed using the free online platform of Majorbio Cloud Platform (http://www.majorbio.com) and Microbiomeanalyst (https://www.microbiomeanalyst.ca/) (Chong et al., 2020). Raw fastq files were demultiplexed, quality‐filtered by Trimmomatic and merged by FLASH with the criteria as we previously described (Yang et al., 2022; Yin et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Excessive consumption of the sugar rich longan fruit promoted the development of nonalcoholic fatty liver disease via mediating gut dysbiosis

Wang

et al. 2022

Food Frontiers

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Background: Controversy exists as towards the association of excessive fruits intake and certain disease risks. Longan is an edible fruit rich in high levels of fructose, glucose and sucrose. The aim of this study was to provide direct evidence on the effect of the sugar rich longan fruit on the development of nonalcoholic fatty liver disease (NAFLD). Chemical pro ling of longan fruit was conducted using LC-HRMS and HPLC-ELSD.Results: Longan extracts at the doses of 4.0 g/kg, 8.0 and 16.0 g/kg were orally administered for 4 weeks to healthy C57BL/6J mice or to C57BL/6J mice fed with a HFD diet. Fecal microbiome was analyzed by 16S rRNA sequencing. The amounts of short chain fatty acids (SCFAs) in colonic contents were determined by GC-MS. Colon and liver tissues were used for histopathological examination after H&E, Masson's trichrome, and Oil-red O staining. ELISA method was used for biochemical analysis in serum. In mice fed a normal diet, repeated longan intake for 4 weeks at excess doses (8 or 16 g/kg), but not the normal dose (4 g/kg), promoted in ammation and gut dysbiosis-like status and reduced short-chain fatty acids (SCFAs) production. In high-fat diet (HFD)-fed mice, longan intake at 4 g/kg hardly in uenced the NAFLD development. In contrast, excess longan intake (8 or 16 g/kg) promoted NAFLD pathogenesis, including increased abnormality in hepatic indices, elevated in ammation, and gut permeability associated with more severe liver steatosis and brosis. Moreover, the exacerbated pathogenic markers were positively correlated with increased blood sugar, aggravated HFD-associated microbial dysbiosis.Conclusions: Effects mediated by excess longan intake resembled that of equivalent free sugars supplementation, suggesting that high level of free sugars in fruits contributed to the promotion of NAFLD development as demonstrated in case of excessive longan intake.

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Pueraria lobata starch regulates gut microbiota and alleviates high-fat high-cholesterol diet induced non-alcoholic fatty liver disease in mice

Cited by 28 publications

References 60 publications

Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens

Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens

Gut microbiota: The key to the treatment of metabolic syndrome in traditional Chinese medicine – a case study of diabetes and nonalcoholic fatty liver disease

Excessive consumption of the sugar rich longan fruit promoted the development of nonalcoholic fatty liver disease via mediating gut dysbiosis

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