Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against <i>Eimeria tenella</i> in chickens

Lin, Mengjuan; Song, Xinhao; Zuo, Runan; Zheng, Yuling; Hu, Shiheng; Gao, Shasha; Chen, Lu; Zhu, Yuan; Xu, Xiaolin; Liu, Moxin; Zhang, Junren; Jiang, Shanxiang; Guo, Dawei

doi:10.1039/d2bm01543a

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…The samples (Lar API, blank Fe-MOF carrier, a Lar and Fe-MOF physical mixture, and Lar@Fe-MOF) and an appropriate amount of Frontiers in Bioengineering and Biotechnology frontiersin.org potassium bromide were mixed in proportion and pressed into tablets. The tablets were then scanned by an FTIR spectroscopy instrument with a wavenumber range of 4,000-400 cm -1 and a resolution of 4 cm -1 (Lin et al, 2023).…”

Section: Fourier Transform Infrared (Ftir) Spectroscopy Analysismentioning

confidence: 99%

Drug delivery system for the extended-release of larotrectinib based on a biocompatible Fe-based metal-organic framework: synthesis, characterization, in vitro release properties and antitumor evaluation

Liu

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Larotrectinib (Lar) is an orally administered tropomyosin receptor kinase (Trk) inhibitor with broad-spectrum antitumor activity that is available in clinical dosage forms as capsules and oral solutions. Currently, corresponding research is focused on developing new extended-release formulation systems for Lar. In this study, a biocompatible Fe-based metal-organic framework (Fe-MOF) carrier was synthesized by a solvent-based method, and a sustained-release drug delivery system (Lar@Fe-MOF) was constructed by nanoprecipitation and Lar loading. Lar@Fe-MOF was characterized by transmission electron microscopy (TEM), differential scanning calorimetry (DSC), fourier transform infrared (FTIR) spectroscopy, and thermogravimetric analysis (TGA), and its drug loading capacity and drug release properties were measured by ultraviolet–visible (UV–vis) spectroscopy. Then, the toxicity and biocompatibility of the Fe-MOF carriers were evaluated using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and hemocompatibility assays. Finally, the anticancer potential of Lar@Fe-MOF was investigated. The TEM results showed that Lar@Fe-MOF had a homogeneous fusiform nanostructural morphology. The DSC and FTIR results showed that Fe-MOF carriers were successfully synthesized and loaded with Lar, which was mainly in an amorphous form. Lar@Fe-MOF showed a large drug loading capacity (–10%) and significant slow-release properties in vitro. The MTT assay results showed that Lar@Fe-MOF had good dose-dependent anticancer activity. The in vivo pharmacodynamic assay results showed that Fe-MOF significantly increased the anticancer activity of Lar and was biocompatible. In conclusion, the Lar@Fe-MOF system developed in this study is a promising drug delivery platform because it is easy to manufacture, has high biocompatibility and ideal drug release and accumulation, can effectively eliminate tumors with improved safety and is expected to further expand therapeutic applications.

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Section: Fourier Transform Infrared (Ftir) Spectroscopy Analysismentioning

confidence: 99%

Drug delivery system for the extended-release of larotrectinib based on a biocompatible Fe-based metal-organic framework: synthesis, characterization, in vitro release properties and antitumor evaluation

Liu

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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“…Kasem et al in another study evaluated the in vitro anticoccidial activities of an ultrasonicated ethanolic extract of Rosmarinus officinalis (UEERO) and its chitosan-based nanoparticles (UEERO-Cs NPs) on Eimeria tenella oocysts of chickens . Also, Lin et al in their findings indicated that the anticoccidial efficacy of Halofuginone hydrobromide (HF) was significantly enhanced after being encapsulated in polymer micelles and further demonstrated the potential protective application of nanoencapsulating anticoccidial drugs as a promising approach to control coccidiosis in poultry . Moreover, Zhang et al prepared MAD-loaded nanostructured lipid carriers (MAD–NLCs) to overcome the defects of Maduramicin ammonium (MAD) by using highly soluble nanostructured lipid carriers (NLCs).…”

Section: Introductionmentioning

confidence: 99%

“…16 Also, Lin et al in their findings indicated that the anticoccidial efficacy of Halofuginone hydrobromide (HF) was significantly enhanced after being encapsulated in polymer micelles and further demonstrated the potential protective application of nanoencapsulating anticoccidial drugs as a promising approach to control coccidiosis in poultry. 17 Moreover, Zhang et al prepared MAD-loaded nanostructured lipid carriers (MAD−NLCs) to overcome the defects of Maduramicin ammonium (MAD) by using highly soluble nanostructured lipid carriers (NLCs). In their investigation, the formulation was optimized via a three-level, three-factor Box−Behnken response surface method.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of ZnO/CuO Nanocomposites Using Parsley Extract for Potential In Vitro Anticoccidial Application

Hamad,

Barzinjy,

Rafigh

et al. 2023

ACS Appl. Bio Mater.

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In this study, a simple, low-cost, and environmentally friendly method for the green synthesis of ZnO/CuO nanocomposites (NCs) using parsley extract was developed. The phytochemical components in the parsley leaf extract reacted with precursor salts in solution and yielded ZnO/CuO NCs. The synthesis of the green-synthesized NCs was confirmed via various characterization techniques, including UV−vis spectroscopy, X-ray diffraction (XRD) analysis, energy-dispersive X-ray (EDX), transmission electron microscopy (TEM), and field emission scanning electron microscopy (FE-SEM). Subsequently, the NCs were subjected to rigorous in vitro evaluation of their anticoccidial properties. The results showed that the NCs had a spherical shape within an average particle size of around 70 nm. The green-synthesized NCs were evaluated for their in vitro anticoccidial activity against Eimeria spp. The findings showed that the NCs exhibited a significant anticoccidial effect, with a maximum inhibition of 55.3 ± 0.32% observed at a concentration of 0.5 mg/mL. The exposure to the NCs resulted in notable alterations in the ultrastructure of the oocysts when compared to the control group. The ZnO/CuO NCs synthesized from the parsley leaf extract showed promising potential against coccidiosis and could be used in biomedical applications. Further investigation using an in vivo model is required to ascertain the efficacy of NCs as anticoccidial agents.

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Maduramicin-guided nanotherapy: A polymeric micelles for targeted drug delivery in canine mammary tumors

Song,

Lin,

Fang

et al. 2024

Biomedicine & Pharmacotherapy

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Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens

Abstract: HF-loaded TPGS polymer micelles (HTPM) were developed to improve the anticoccidial effect of loaded drugs by enhancing cellular take up, denaturing merozoites inside infected cells, and restoring the gut microbiome.

Cited by 5 publications

References 47 publications

Drug delivery system for the extended-release of larotrectinib based on a biocompatible Fe-based metal-organic framework: synthesis, characterization, in vitro release properties and antitumor evaluation

Drug delivery system for the extended-release of larotrectinib based on a biocompatible Fe-based metal-organic framework: synthesis, characterization, in vitro release properties and antitumor evaluation

Green Synthesis of ZnO/CuO Nanocomposites Using Parsley Extract for Potential In Vitro Anticoccidial Application

Maduramicin-guided nanotherapy: A polymeric micelles for targeted drug delivery in canine mammary tumors

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