Puckered chin sign in systemic sclerosis

Machine learning encodes urine and serum metabolic patterns for autoimmune disease discrimination, classification and metabolic dysregulation analysis

“…For serum samples, the gradient was increased from 5% to 10% B over 5 min, increased to 85% B over 10 min, increased to 100% B over 17 min, held for 8 min, decreased to 5% B over 5 min, and equilibrated for 5 min. 10 The mobile phase flow rate was 0.4 mL min −1 . The injection volume was 5 μL.…”

“…SSc is one of multiple cutaneous sclerosing disorders and it may be difficult to differentiate clinically. 10 CTD, also referred to as collagen vascular disease, afflicts the proteins that function to create the connective tissue framework of the body. 11 The difficulty in the accurate diagnosis of ADs is largely due to the complicated underlying pathological mechanisms not being fully understood.…”

Immunologic and nonimmunologic sclerodermal skin conditions - review

“…The differential diagnosis between SSc and other diseases with scleroderma-like skin lesions is difficult. The authors have shown that the “puckered chin sign” is characteristic of SSc and differentiates it from other sclerodermal lesions ( 1 ).…”

“…The correct diagnosis of these lesions based on the clinical elements supplemented with paraclinical data is essential in order to correctly direct the therapeutic attitude (1)(2)(3). These scleroderma-like disorders can be inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenic systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyria cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum) (1)(2)(3). The presence of sclerodermiform lesions in the graft-versus-host suggests the autoimmune substrate of the lesion (3).…”

“…Sclerodermal lesions have also been observed in some inherited diseases, such as progeria and other progeroid syndromes and in fascial dystrophy which is also called stiff skin syndrome (1)(2)(3). Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment (Table 1) (3,4,(104)(105)(106)(107).…”