Published material used without proper attribution: Lesson learned

Abstract

as opposed to the aforementioned factor of 1.86. If the new dosage of 110 mg twice daily were used for CL cr values of 30-50 mL/min, the average C ss values would be similar: 0.231, 0.236, and 0.235 mg/mL for CL cr values of >50, 30-50, and <30 mL/min, respectively. Dosages appearing in dabigatran product labeling may not be optimal for patients with a CL cr of 30-50 mL/min. For this group, a dabigatran etexilate dosage of 110 mg orally twice daily may produce a better balance of safety and effectiveness. A 110-mg dosage form of dabigatran etexilate is available in Canada but not in the Unit-5. Connolly SJ, Ezekowitz MD, Yusuf S et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009; 361:1139-51. 6. Hankey GJ, Eikelboom JW. Dabigatran etexilate: a new oral thrombin inhibitor.ed States, but a 150-mg capsule could be taken in the morning and a 75-mg capsule at night.