Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis

Dong, Rui; Hong, Wang; Ye, Jishi; Wang, Ming-Shan; Bi, Yan‐Lin

doi:10.3389/fnhum.2019.00259

Cited by 45 publications

(34 citation statements)

References 27 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies are ongoing to understand further the underlying mechanism of the disease that would assist in developing more effective therapeutic agents that may improve the treatment of Alzheimer's disease. The principal goals of Alzheimer's research are to determine when and how interventions can slow or stop cognitive decline in patients and identify early signs of decline and treatment response (Dong et al, 2019 ). However, more budget from these countries on the subject is highly imperative to allow more treatments to be carried out in clinical trials.…”

Section: Resultsmentioning

confidence: 99%

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

et al. 2021

View full text Add to dashboard Cite

Microbial infections have been linked to the pathogenesis and pathophysiology of Alzheimer's disease (AD) and other neurodegenerative diseases. The present study aimed to synthesise and assess global evidence of microbial pathogenesis and pathophysiology in AD (MPP-AD) and associated neurodegenerative conditions using integrated science mapping and content analytics to explore the associated research landscape. Relevant MPP-AD documents were retrieved from Web of Science and Scopus according to PRISMA principles and analysed for productivity/trend linked to authors/countries, thematic conceptual framework, and international collaborative networks. A total of 258 documents published from 136 sources to 39.42 average citations/document were obtained on MPP-AD. The co-authors per document were 7.6, and the collaboration index was 5.71. The annual research outputs increased tremendously in the last 6 years from 2014 to 2019, accounting for 66% compared with records in the early years from 1982 to 1990 (16%). The USA (n = 71, freq. = 30.34%), United Kingdom (n = 32, freq. = 13.68%) and China (n = 27, 11.54%) ranked in first three positions in term of country's productivity. Four major international collaboration clusters were found in MPP-AD research. The country collaboration network in MPP-AD was characteristic of sparse interaction and acquaintanceship (density = 0.11, diameter = 4). Overall, international collaboration is globally inadequate [centralisation statistics: degree (40.5%), closeness (4%), betweenness (23%), and eigenvector (76.7%)] against the robust authors' collaboration index of 5.71 in MPP-AD research. Furthermore, four conceptual thematic frameworks (CTF) namely, CTF#1, roles of microbial/microbiome infection and dysbiosis in cognitive dysfunctions; CTF#2, bacterial infection specific roles in dementia; CTF#3, the use of yeast as a model system for studying MPP-AD and remediation therapy; and CFT#4, flow cytometry elucidation of amyloid-beta and aggregation in Saccharomyces cerevisiae model. Finally, aetiology-based mechanisms of MPP-AD, namely, gut microbiota, bacterial infection, and viral infection, were comprehensively discussed. This study provides an overview of MPP-AD and serves as a stepping stone for future preparedness in MPP-AD-related research.

show abstract

Section: Resultsmentioning

confidence: 99%

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Amongst the top 10 types of pain, the most popular study type was neuropathic pain with the most publications (860), citations (32,515), and the highest H-index value (87). According to the keywords with the strongest citation bursts, our results found that the top 61 keywords since 1981 were as follows: “gene related peptide”, “rat spinal cord”, “substance p”, and “tumor necrosis factor.” Large clusters in keyword cooccurrence networks imply substantial research hotspots [ 46 ]. In the past 40 years, as the research covering comorbid pain and inflammation was gradually converted from phenomenon to mechanism, we were optimistic that more effective treatments will be developed in the predictable future.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of Research on the Comorbidity of Pain and Inflammation

Xiong

Zhang

Wang

2021

Pain Research and Management

View full text Add to dashboard Cite

Objectives. To provide a comprehensive review on the global scientific research status of comorbid pain and inflammation from 1981 to 2019 and capture its subsequent development trends. Data Sources. The primary database chosen to collect publications on comorbid pain and inflammation research from 1981 to 2019 was the Web of Science (WOS). Core of the search strategy was the key word “pain” and the key word “inflammation” in the medical subject headings’ major field. Study Selection. All articles retrieved were included in the bibliometric analysis. Data Extraction. We used CiteSpace to analyze publication outputs, subject categories, distribution by country/institution/journal, and other types of information. Then, knowledge base, hot issues, and future development directions were explained. Data Synthesis. A total of 2887 papers met the inclusion criteria in our research. Linear regression analysis results showed that the publications of studies of comorbid pain and inflammation significantly increased ( P < 0.001 ) and have grown about 192 times in 40 years. The countries with the most outputs were the USA (886 publications), China (375 publications), and England (236 publications). Besides, Harvard University was the most prolific institution with 730 publications and 6646 citations. In accordance with the subject categories of WOS, neurosciences (31.832%), pharmacology/pharmacy (18.427%), and clinical neurology (15.206%) were the main research areas of these 2887 papers. Conclusions. The current study reveals that research on comorbid pain and inflammation has gradually become more extensive worldwide since 1981, and neuropathic pain was the most popular study type. Most of our research output in this field came from countries in Europe and North America, although some Asian countries showed promising performance.

show abstract

“…Remarkably, around half (46.4%) of all medical error publications were affiliated with the United States (being also the home country of Professor Bates), where 8 out of the top 10 most productive institutions were located ( Table 1 ). While the United States is clearly one of the leading countries in terms of scientific productivity in many different research areas, its publication share (46.4%) in the medical errors literature is clearly higher than the shares of publications affiliated with the United States in other scientific areas with medical relevance such as Alzheimer disease (39.4%) ( 20 ), bariatric surgery (39.3%) ( 21 ), and neuropharmacology (38.0%) ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

First, Do No Harm (Gone Wrong): Total-Scale Analysis of Medical Errors Scientific Literature

Atanasov

Yeung

Klager

et al. 2020

Front. Public Health

View full text Add to dashboard Cite

Objective: Medical errors represent a leading cause of patient morbidity and mortality. The aim of this study was to quantitatively analyze the existing scientific literature on medical errors in order to gain new insights in this important medical research area. Study Design: Web of Science database was used to identify relevant publications, and bibliometric analysis was performed to quantitatively analyze the identified articles for prevailing research themes, contributing journals, institutions, countries, authors, and citation performance. Results: In total, 12,415 publications concerning medical errors were identified and quantitatively analyzed. The overall ratio of original research articles to reviews was 8.1:1, and temporal subset analysis revealed that the share of original research articles has been increasing over time. The United States contributed to nearly half (46.4%) of the total publications, and 8 of the top 10 most productive institutions were from the United States, with the remaining 2 located in Canada and the United Kingdom. Prevailing (frequently mentioned) and highly impactful (frequently cited) themes were errors related to drugs/medications, applications related to medicinal information technology, errors related to critical/intensive care units, to children, and mental conditions associated with medical errors (burnout, depression). Conclusions: The high prevalence of medical errors revealed from the existing literature indicates the high importance of future work invested in preventive approaches. Digital health technology applications are perceived to be of great promise to counteract medical errors, and further effort should be focused to study their optimal implementation in all medical areas, with special emphasis on critical areas such as intensive care and pediatric units.

show abstract

Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis

Cited by 45 publications

References 27 publications

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

Bibliometric Analysis of Research on the Comorbidity of Pain and Inflammation

First, Do No Harm (Gone Wrong): Total-Scale Analysis of Medical Errors Scientific Literature

Contact Info

Product

Resources

About