Scientists have developed different framings to explain human behaviour, from the structural context to the individual motivation down to the neurobiological implementation. We know comparatively little about how non-experts interpret these scientific framings, and what they infer when one framing rather than another is made salient. In four experiments, UK volunteers read vignettes describing the same behaviour, but using different explanatory framings. In study 1, we found that participants grouped explanatory framings into ‘biological’, ‘psychological’ and ‘sociocultural’ clusters. Different framings were often seen as incompatible with one another, especially when one belonged to the ‘biological’ cluster and the other did not. In study 2, we found that adopting a particular explanatory framing produced spontaneous inferences. Specifically, psychological framings led participants to assume the behaviour was malleable, and biological framings led them to assume it was not. In studies 3 and 3b, we found that the choice of explanatory framing can affect people’s conclusions about effective interventions. For example, presenting a biological framing increased people’s conviction that interventions like drugs would be effective, and decreased their conviction that psychological or socio-political interventions would be effective. These results illuminate the intuitive psychology of explanations, and also some pitfalls in scientific communication. Foregrounding a particular explanatory framing is likely to produce ideas in the audience – about what other factors are not causally important, how easy it is to change the behaviour, and what kinds of remedies are worth considering – that the communicator may not intend and that may not follow logically.