Public Health Risks of Multiple-Drug-Resistant Enterococcus spp. in Southeast Asia

Daniel, Diane; Lee, Sui Mae; Dykes, Gary A.; Rahman, Sadequr

doi:10.1128/aem.01741-15

Cited by 46 publications

(37 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concern the resistance patterns, MDR, XDR and PDR, the results revealed that 1/28 Different percentage of MDR-enterococci were stated in many studies (28-63%) [47][48][49][50] . XDRenterococci were also stated in many studies and compile ( 8-35%) of isolated enterococci.…”

Section: Resultsmentioning

confidence: 99%

Phenotypic Investigation of Vancomycin, Teicoplanin and Linezolid Resistance Among Enterococcus spp. Isolated from Children Diarrhea

Al-Dahmoshi¹,

Rabeea²,

Aridhee³

et al. 2019

J Pure Appl Microbiol

View full text Add to dashboard Cite

Vancomycin-resistant Enterococci(VRE) were common among Enterococcus. faecalis and Enterococcus faecium. Teicoplanin resistance or sensitivity can determine the VRE phenotypes whether VanA (Van R /tec R) or VanB (Van R / tec s). Linezolid resistance among VRE regards an newly emerged health problem. Infection with LRVRE or TRLRVRE pushan hazardous alert for hard to heal illness. Twenty eight Enterococcus spp. isolates were recovered from children diarrhea after their inoculation on m-EI chromogenic agar. Antibiotics susceptibility and phenotypic detection of antibiotics resistance were performed according to CLSI 2016. The results revealed 92.86% resistance to rifampin, 85.71% to erythromycin. VRE were 46.42%, TRE were 25% and LRE were 35.71% while co-existed resistance for Vancomycin/Teicoplanin/Linezolid(TRLRVRE) were detected 25% in. concern antibiotics resistant patterns, the MDR compile (85.7%) while XDR compile (10.7%) and there is no PDR among Enterococcus. spp. isolates were PDR. The presentstudy conclude that VanA and VanB phenotypes were common among MDR and XDR and although there is no using of linezolid but the emergence of TRLRVRE isolates were stated.

show abstract

Section: Resultsmentioning

confidence: 99%

Phenotypic Investigation of Vancomycin, Teicoplanin and Linezolid Resistance Among Enterococcus spp. Isolated from Children Diarrhea

Al-Dahmoshi¹,

Rabeea²,

Aridhee³

et al. 2019

J Pure Appl Microbiol

View full text Add to dashboard Cite

show abstract

“…They cause frequently more infections in patients hospitalized for a long time or who have received multiple antibiotic therapy [1,2]. E. faecalis and E. faecium are the most prevalent species cultured from human infections and are frequently associated with nosocomial infections worldwide [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility and virulence factors of enterococci colonizing intestinal tract of Jordanian infants

Alnasra

Badran

Dajan

et al. 2016

int. arab. j antimicrob. agents

View full text Add to dashboard Cite

Objective: This study investigated distribution of enterococci colonizing intestinal tract of infants, their putative virulence factors and antimicrobial susceptibility patterns. Methods: A total of 82/186 (44.1%) fecal enterococcal isolates were recovered from infants. All enterococci isolates were identified either E. faecalis or E. faecium using culture and PCR. Results: A significant higher intestinal colonization of enterococci was detected among non-hospitalized compared to hospitalized patients with a percentage of (72 % vs. 28%), respectively. E. faecalis was the predominant species isolated from both groups (75.6%). It had also significantly higher virulence factors genes than E. faecium, while E. faecium had higher rates of antimicrobial resistance than E. faecalis. There was no significant factor related to intestinal colonization of enterococci with birth weight, gestational age of mother, gender, type of feeding, present of disease or administration of antibiotics to mothers or infants. Conclusion: This study presents important epidemiological data on the intestinal colonization of enterococci in both hospitalized and nonhospitalized Jordanian infants.

show abstract

“…The ability of bacteria to adapt and become resistant to antibiotics has been recognized by the scientific community for many decades. Staphylococcus aureus, 1 Acinetobacter baumannii, 2 and Enterococci species 3 are just some of the nosocomial pathogens with increased antimicrobial resistance (AMR) that cause difficult-to-treat infections worldwide. AMR is commonly accrued through genetic changes, which confer a more resistant phenotype on the cell, or through the integration of the cell into a biofilm, which can lead to a transient increase in tolerance to antibiotics of up to 1,000-fold.…”

Section: The Problem Of Antibiotic Resistancementioning

confidence: 99%

On the antibacterial effects of manuka honey: mechanistic insights

Roberts¹,

Brown²,

Jenkins³

2015

RRB

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) is an increasing clinical problem precipitated by the inappropriate use of antibiotics in the later parts of the 20th Century. This problem, coupled with the lack of novel therapeutics in the development pipeline, means AMR is reaching crisis point, with an expected annual death rate of ten million people worldwide by 2050. To reduce, and to potentially remedy this problem, many researchers are looking into natural compounds with antimicrobial and/or antivirulence activity. Manuka honey is an ancient antimicrobial remedy with a good track record against a wide range of nosocomial pathogens that have increased AMR. Its inhibitory effects are the result of its constituent components, which add varying degrees of antimicrobial efficacy to the overall activity of manuka honey. The antimicrobial efficacy of manuka honey and some of its constituent components (such as methylglyoxal and leptosperin) are known to bestow some degree of antimicrobial efficacy to manuka honey. Despite growing in vitro evidence of its antimicrobial efficacy, the in vivo use of manuka honey (especially in a clinical environment) has been unexpectedly slow, partly due to the lack of mechanistic data. The mechanism by which manuka honey achieves its inhibitory efficacy has recently been identified against Staphylococcus aureus and Pseudomonas aeruginosa, with both of these contrasting organisms being inhibited through different mechanisms. Manuka honey inhibits S. aureus by interfering with the cell division process, whereas P. aeruginosa cells lyse in its presence due to the reduction of a key structural protein. In addition to these inhibitory effects, manuka honey is known to reduce virulence, motility, and biofilm formation. With this increasing in vitro dataset, we review the components and our mechanistic knowledge of manuka honey and how manuka honey could potentially be utilized in the future to impact positively on the treatment of microbial, resistant infections.

show abstract

Public Health Risks of Multiple-Drug-Resistant Enterococcus spp. in Southeast Asia

Cited by 46 publications

References 50 publications

Phenotypic Investigation of Vancomycin, Teicoplanin and Linezolid Resistance Among Enterococcus spp. Isolated from Children Diarrhea

Phenotypic Investigation of Vancomycin, Teicoplanin and Linezolid Resistance Among Enterococcus spp. Isolated from Children Diarrhea

Antimicrobial susceptibility and virulence factors of enterococci colonizing intestinal tract of Jordanian infants

On the antibacterial effects of manuka honey: mechanistic insights

Contact Info

Product

Resources

About