Phenotypic Investigation of Vancomycin, Teicoplanin and Linezolid Resistance Among Enterococcus spp. Isolated from Children Diarrhea

Abstract

Vancomycin-resistant Enterococci(VRE) were common among Enterococcus. faecalis and Enterococcus faecium. Teicoplanin resistance or sensitivity can determine the VRE phenotypes whether VanA (Van R /tec R) or VanB (Van R / tec s). Linezolid resistance among VRE regards an newly emerged health problem. Infection with LRVRE or TRLRVRE pushan hazardous alert for hard to heal illness. Twenty eight Enterococcus spp. isolates were recovered from children diarrhea after their inoculation on m-EI chromogenic agar. Antibiotics susceptibility and phenotypic detection of antibiotics resistance were performed according to CLSI 2016. The results revealed 92.86% resistance to rifampin, 85.71% to erythromycin. VRE were 46.42%, TRE were 25% and LRE were 35.71% while co-existed resistance for Vancomycin/Teicoplanin/Linezolid(TRLRVRE) were detected 25% in. concern antibiotics resistant patterns, the MDR compile (85.7%) while XDR compile (10.7%) and there is no PDR among Enterococcus. spp. isolates were PDR. The presentstudy conclude that VanA and VanB phenotypes were common among MDR and XDR and although there is no using of linezolid but the emergence of TRLRVRE isolates were stated.

Vancomycin resistant enterococci gut Colonization and its associated factors among HIV infected patients on anti-Retro viral therapy in Ethiopia

“…However, the prevalence of VRE in our study was lower than the report from Ireland (44.1%) (4), Germany (26.1%) (32) Brazil (23.4%) (1), India (19.6%) (33), Saud Arabia (17.3%) (5) and Iraq (46.4%) (17). The lower prevalence in the present study might be due to the variation in study settings in which most of the previous countries have been using oral and intravenous vancomycin massively for human diseases (34,35), and variation in study participants in which in the previous studies most of the study participants were hospitalized patients and critically ill patients in ICU who were frequently exposed to different antibiotics and experienced insertion of external devices like catheter (7).…”

“…Moreover, the present study also showed that 49.6% of Enterococci isolates were multidrug resistant. This result is lower than the ndings in Iraq (85.7%) (17) and Ethiopia 80.8% (41). In contrary, the result is higher than the nding in Ethiopia 29.5% (16).…”

“…Furthermore, few options are left for management of diseases caused by VRE, and hence causing increased mortality on infected individuals (12,14). VRE now represent approximately one third of Enterococcus isolates (17).…”

Vancomycin resistant Enterococci and its associated factors among HIV infected patients on anti-retroviral therapy in Ethiopia

“…Ireland (44.1%) [4], Germany (26.1%) [32] Brazil (23.4%) [1], India (19.6%) [33], Saud Arabia (17.3%) [5] and Iraq (46.4%) [17] where these studies were conducted on the population where HIV status not determined. The lower prevalence in the present study might be due to the variation in study settings in which most of the previous countries have been using oral and intravenous vancomycin massively for human diseases [34,35], and variation in study participants where the previous studies participants were hospitalized patients and critically ill patients in ICU who were frequently exposed to different antibiotics and experienced insertion of external devices like catheter [7].…”

“…Furthermore, few options are left for management of diseases caused by VRE, and hence causing increased mortality on infected individuals. VRE now represent approximately one third of Enterococcus isolates [6][7][8][9][10][11][12][13][14][15][16][17].…”